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中国科学院上海药物研究所导师教师师资介绍简介-李亚平

本站小编 Free考研考试/2021-02-10

xm:李亚平
xb:男
zc:研究员
xl:博士
dh:+86--1515
cz:
dzyj:ypli@simm.ac.cn
grzy:
zjlb:研究员,基金委创新群体学术带头人,****, 973首席科学家;新药;
zw:研究组长,博士生导师,药物制剂研究中心主任
txdz:上海市浦东张江高科技园区海科路501号
grjj:
yjfx:1. 纳米载药系统抗肿瘤转移与克服肿瘤耐药
2. 核酸药物非病毒载体及导入系统
3. 创新药物与高端制剂的研究开发

dblz:在国际重要学术期刊上发表200余篇高质量论文,其中IF>10 的论文90余篇,包括著名国际刊物Chem Soc Rev, Nat Med, Adv Mater, Nat Commun, Sci Immunol, Nano Today, ACS Nano, Nano Lett, J Am Chem Soc, Adv Sci, Adv Funct MaterAdv Drug Deliv Rev等, 代表性论文如下:

1.Lei Fang, Zitong Zhao, Jue Wang, Pengcheng Zhang, Yaping Ding, Yanyan Jiang, Dangge Wang*, Yaping Li*. Engineering autologous tumour cellvaccine to locally mobilize antitumourimmunity in tumour surgical bed. Sci Adv 6(2020) eaba4024

2.Lei Zhou, Pengcheng Zhang, Hao Wang, Dangge Wang*,Yaping Li*. Smart nanosized drug delivery systems inducing immunogenic cell death for combination with cancer immunotherapy. Acc Chem Res 53(2020) 1761-72

3.Jie Li, Hong Wang, Yuqi Wang, Xiang Gong, Xiaoxuan Xu,XianyiSha, Ao Zhang*, Zhiwen Zhang*, Yaping Li*. Tumor-activated size-enlargeable bioinspired lipoproteins access cancer cells in tumor to elicit anti-tumor immune responses. Adv Mater 32(2020) **

4.Lei Zhou, Bo Hou, Dangge Wang, Fang Sun, Rundi Song, Qian Shao, Hao Wang, Haijun Yu*, Yaping Li*. Engineering polymeric prodrug nanoplatform for vaccination immunotherapy of cancer. Nano Lett 20(2020) 4393-402

5.Ang Gao, Binfan Chen, Jing Gao, Fengqi Zhou, Madiha Saeed, Bo Hou, Yaping Li*, Haijun Yu*. Sheddable prodrug vesicles combating adaptive immune resistance for improved photodynamic immunotherapy of cancer. Nano Lett 20(2020):353-362

6.Bing Feng, Zifei Niu, Bo Hou, Lei Zhou, Yaping Li*, Haijun Yu*. Enhancing triplenegative breast cancer immunotherapy by ICG-templated self-assembly of paclitaxel nanoparticles. Adv Funct Mater 2019, **

7.Xiaochen Liu, Dangge Wang*, Pengcheng Zhang, Yaping Li*. Recent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer. Nano Today 29 (2019) 100801

8.Dangge Wang, Tingting Wang, Haijun Yu,* Bing Feng, Lei Zhou, Fangyuan Zhou, Hanwu Zhang, Min Luo, Yaping Li*. Engineered antibody nanoparticles overcomes immunological tolerance to PD-L1 blockade therapy. Sci Immunol 4(2019) eaau6584

9.Pengcheng Zhang,YihuiZhai,Ying Cai, Yuliang Zhao*, Yaping Li*. Nanomedicine-based immunotherapy for the treatment of cancer metastasis. Adv Mater 2019:**

10.Bing Feng, Bo Hou, Fangyuan Zhou, HaijunYu*, Dangge Wang, Zifei Niu, Zhiai Xu, Yaping Li*. Self-amplified drug delivery with light-inducible nanocargoesto enhance cancer immunotherapy. Adv Mater 31(2019) **

11.Junyang Wang, Jia Meng, Wei Ran, Robert J. Lee, Lesheng Teng*, Pengcheng Zhang*,Yaping Li*. Hepatocellular carcinoma growth retardation and PD-1 blockade therapy potentiation with synthetic high-density lipoprotein. Nano Lett 19(2019)5266-76

12.Xiang Gong, Jie Li, Zhiwan Wang, Hong Wang, Yuqi Wang, Xiaoxuan Xu,Zhiwen Zhang*,Yaping Li*. Emerging approaches of cell-based nanosystems to target cancer metastasis. Adv Funct Mater 2019: **

13.Tao Tan, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Siling Wang, Zhiwen Zhang*, Yaping Li*. Bioinspired lipoproteins-mediatedphotothermiaremodels tumor stroma to improvecancer cellaccessibility of second nanoparticles. Nat Commun 10(2019)3322

14.Fangyuan Zhou,Bing Feng, Haijun Yu*, Dangge Wang, Tingting Wang, Ang Gao, Siling Wang, Yuting Ma, Yaping Li*. Tumor microenvironment-activatable prodrug vesicles for nano-enabled cancer immunotherapy byimmunogenic cell death and CD47 blockade. Adv Mater 2019:**

15.Tianqun Lang, Yiran Liu, Zhong Zheng, Wei Ran, Yihui Zhai, Qi Yin*, Pengcheng Zhang, Yaping Li*. Cocktail strategy based on spatio-temporally controlled nano device improves therapy of breast cancer. Adv Mater 2019: **

16.Tao Tan, Hong Wang, Haiqiang Cao, LijuanZeng, Yuqi Wang, Zhiwan Wang, Jing Wang, Jie Li, Siling Wang*, Zhiwen Zhang*, Yaping Li *. Deep tumor-penetrated nanocages improve accessibility to cancer stem cells for photothermal-chemotherapy of breast cancer metastasis. Adv Sci.2018,**

17.Haiqiang Cao, Hong Wang, Xinyu He, Tao Tan, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Zhiwen Zhang*, Yaping Li*. Bioengineered macrophages can responsively transform into nanovesicles to target lung metastasis. Nano Lett18(2018):4762-70

18.YihuiZhai, Wei Ran, Jinghan Su, Tianqun Lang, JiaMeng, Guanru Wang, Pengcheng Zhang*, and Yaping Li*. Traceable bioinspired nanoparticle for the treatment of metastatic breast cancer via NIR-trigged intracellular delivery of methylene blue and cisplatin. Adv Mater 2018, **

19.Bing Feng, Fangyuan Zhou,Bo Hou,Dangge Wang,Tingting Wang,Yuanlei Fu, Yuting Ma, Haijun Yu*, Yaping Li*. Binary cooperative prodrugnanoparticles improve immunotherapy by synergistically modulating immune tumor microenvironment. Adv Mater 2018, **

20.Tingting Wang, Dangge Wang, Haijun Yu,* Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Shi Jiao, Yaping Li*. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nat Commun 9(2018):1532


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