xm:甘勇
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:ygan@simm.ac.cn
grzy:
zjlb:研究员,新药
zw:中科院上海药物所研究组长、博士生导师
txdz:上海市浦东新区张江高科技园区海科路501号
grjj:甘勇，上海药物研究所研究员，课题组长，博士生导师。在应用基础研究领域，围绕生物体内复杂的生理屏障，从物理药剂学角度出发，开展了新型功能型载体制剂的设计及其克服生理屏障机制的研究，取得了系列成果。先后在Science Advances、Nature Communications、PNAS、ACS Nano、Nano Letters、Advanced Functional Materials、Biomaterials、Journal of Controlled Release等国内外期刊上发表研究论文70余篇；参编专著4部。在高端制剂转化及产业化方面，理性化设计制备多个创新制剂，显示了良好的成药性，目前正在不同阶段的临床转化和推进；获得授权专利35项，新药临床批件15项，研发上市创新制剂4项。

yjfx:1. 药物载体高效递送的物理药剂学研究。
2. 新型功能型药物载体的理性化设计及其克服关键生理屏障机制的研究。
3. 具有显著临床价值高端创新制剂的转化研究。
dblz:1.Aohua Wang#, Weiwei Fan#, Tiantian Yang, Shufang He, Yiwei Yang, Miaorong Yu, Li Fan, Quanlei Zhu, Shiyan Guo, Chunliu Zhu, Yong Gan*. Liver-target and glucose-responsive polymersomes toward mimicking endogenous insulin secretion with improved hepatic glucose utilization. Advanced Functional Materials. 2020, 30(13):**.

2.Di Nie#, Zhuo Dai#, Jialin Li#, Yiwei Yang, Ziyue Xi, Jie Wang, Wei Zhang, Kun Qian, Shiyan Guo, Chunliu Zhu, Rui Wang, Yiming Li, Miaorong Yu, Xinxin Zhang, Xinghua Shi, Yong Gan*. Cancer-cell-membrane-coated nanoparticles with a yolk-shell structure augment cancer chemotherapy. Nano Letters. 2020, 20(2):936-946.

3.Yiwei Yang#, Falin Tian#, Di Nie#, Yuan Liu, Kun Qian, Miaorong Yu, Aohua Wang, Yaqi Zhang, Xinghua Shi*, Yong Gan*. Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues. Science Advances. 2020, 6(6):eaay9937.

4.Shiyan Guo, Di Sun, Dalong Ni, Miaorong Yu, Kun Qian, Wei Zhang, Yiwei Yang, Sha Song, Yang Li, Ziyue Xi, Jie Wang, Jingyi Li, Yan Wei, Kaixian Chen*, Yong Gan*, Zhengtao Wang*. Smart tumor microenvironment-responsive nanotheranostic agent for effective cancer therapy. Advanced Functional Materials. 2020.

5.Zhuo Dai#, Miaorong Yu#, Xin Yi*, Zeming Wu, Falin Tian, Yunqiu Miao, Wenyi Song, Shufang He, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Xinxin Zhang, Yiming Li, Xinghua Shi, Rui Wang*, Yong Gan*. Chain-length- and saturation-tuned mechanics of fluid nanovesicles direct tumor delivery. ACS Nano. 2019, 13(7):7676-7689.

6.Miaorong Yu#, Wenyi Song#, Falin Tian#, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi*, Yong Gan*, Huajian Gao*. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proceedings of the National Academy of Sciences of the United States of America. 2019, 116(12):5362-5369.

7.Weiwei Fan, Dengning Xia, Quanlei Zhu, Xiuying Li, Shufang He, Chunliu Zhu, Shiyan Guo, Lars Hovgaard, Mingshi Yang, Yong Gan*. Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018, 151:13-23.

8.Miaorong Yu#, Lu Xu#, Falin Tian#, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, Xinxin Zhang, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nature Communications. 2018, 9(1):2607.

9.Shufang He, Weiwei Fan, Na Wu, Jingjing Zhu, Yunqiu Miao, Xiaran Miao, Feifei Li, Xinxin Zhang*, Yong Gan*. Lipid-based liquid crystalline nanoparticles facilitate cytosolic delivery of siRNA via structural transformation. Nano Letters. 2018, 18(4):2411-2419.

10.Miaorong Yu#, Jiuling Wang#, Yiwei Yang#, Chunliu Zhu, Qian Su, Shiyan Guo, Jiashu Sun, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rotation-facilitated rapid transport of nanorods in mucosal tissues. Nano Letters. 2016, 16(11):7176-7182.

jyjl:1997.09 - 2002.06沈阳药科大学，药学院，药剂学，博士