xm:吴婉莹
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:wanyingwu@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海浦东张江海科路501号
grjj:现任中国科学院上海药物研究所研究员、博士生导师，中药现代化中心副主任。2002年毕业于北京中医药大学，获理学博士学位；同年入北京大学药学院从事博士后研究；出站后在中国科学院上海药物研究所工作，2011年评聘为研究员。2013年3月-6月作为访问科学家在美国药典委工作。目前担任第十一届国家药典委员会委员，美国药典东亚专家组成员，世界中联中药分析专业委员会理事兼秘书长，SCI杂志《Phytomedicine》的编委、《中草药》杂志英文版的编委。吴婉莹研究员主要致力于中药质量控制研究及现代中药新药研发工作。所开发的丹七通脉片获得中药五类新药临床研究批件，目前正在进行临床II期研究； 所制定28种中药及复方的质量标准中，16种中药32个国际标准标准获得国际认可，已经纳入美国或欧洲药典。主持了十一五国家科技重大专项、科技部国际合作、国家自然基金、海洋863计划，上海市科委及中科院等11项国家及省部级课题，并参与二十余项基金课题的研究。在国内外著名学术期刊发表文章114篇，其中SCI收录96篇。并为《丹参大全》、《常用中药超高效液相色谱分析》、《中药现代化二十年》、《海洋天然产物与药物研究开发》及2010版、2015版英文版药典6部专著的编委。申请国内发明专利19项，其中14项已获得授权。2012年，作为主要科研骨干参与的“中药复杂体系活性成分系统分析方法及其在质量标准中的应用研究”项目获得国家自然科学奖二等奖（排名第三）。2015年获中华中医药学会一等奖（排名第二）。2016年，作为主要科研骨干参与的“国际化导向的中药整体质量标准体系创建与应用”项目获得国家科技进步奖二等奖（排名第三）。2013年、2017年分别获上海科技系统及上海市“三八红旗手”称号，2019年江西省“双千计划”。
yjfx:现代中药新药研发及中药质量控制研究。
dblz:1. Huiqin Pan#, Wenzhi Yang#, Changliang Yao, Yao Shen, Yibei Zhang, Xiaojian Shi, Shuai Yao, Wanying Wu*, Dean Guo*. Mass defect filtering-oriented classification and precursor ions list-triggered high-resolution mass spectrometry analysis for the discovery of indole alkaloids from Uncaria sinensis, J Chromatogr A., 2017, 1516: 102–113.
2. Changliang Yao#, Wenzhi Yang#, Wen Si, Yao Shen, Naixia Zhang, Huali Chen, Huiqin Pan, Min Yang, Wanying Wu*, Dean Guo*. An enhanced targeted identification strategy for the selectiveidentification of flavonoid O-glycosides from Carthamus tinctorius byintegrating offline two-dimensional liquid chromatography/linearion-trap-Orbitrap mass spectrometry, high-resolution diagnosticproduct ions/neutral loss filtering and liquid chromatography-solidphase extraction-nuclear magnetic resonance, J Chromatogr A., 2017, 1491: 87-97.
3. Xiaojian Shi#, Wenzhi Yang#, Shi Qiu, Changliang Yao, Yao Shen, Qirui Bi, Min Yang, Wanying Wu*, Dean Guo*. An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng, Anal Chim Acta., 2017, 952: 59-70.
4. Qirui Bi#, JinjunHou#, PengQi#, ChunhuaMa, Ruihong Feng, Bingpeng Yan, Jianwei Wang, Xiaojian Shi, Yuanyuan Zheng, Wanying Wu*, Dean Guo*, TXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats, Sci Rep., 2016, 6: 22759.
5. Shi Qiu#, Wen-zhi Yang#, Chang-liang Yao, Zhi-dong Qiu, Xiao-jian Shi, Jing-xian Zhang, Jin-jun Hou, Qiu-rong Wang, Wanying Wu*, Dean Guo*, Nontargeted metabolomic analysis and \"commercial-homophyletic\" comparison-induced biomarkers verification for the systematic chemical differentiation of five different parts of Panax ginseng, J Chromatogr A, 2016, 1453: 78-87.
6. Shi Qiu#, Wenzhi Yang#, Xiaojian Shi, Changliang Yao, Min Yang, Xuan Liu, Baohong Jiang, Wanying Wu*, Dean Guo*, A green protocol for efficient discovery of novel natural compounds: Characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study, Anal Chim Acta., 2015, 93: 65-76.
7. Ruihong Feng#, Jinjun Hou#, Yibei Zhang, Huiqin Pan, Wenzhi Yang, Peng Qi, Shuai Yao, Luying Cai, Min Yang, Baohong Jiang, Xuan Liu, Wanying Wu*, Dean Guo*, An efficient and target-oriented sample enrichment method for preparative separation of minor alkaloids by pH-zone-refining counter-current chromatography, J Chromatogr A, 2015, 1409: 159-165.
8. Changliang Yao#, Wenzhi Yang#, Wanying Wu*, Juan Da, Jinjun Hou,Jingxian Zhang, Yanhai Zhang, Yan Jin, Min Yang, Baohong Jiang, Xuan Liu, Dean Guo*, Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines, J Chromatogr A, 2015, 1402: 71-81.
9. Juan Da, Wanying Wu*, Jinjun Hou, Huali Long, Shuai Yao, Zhou Yang, Luying Cai, Min Yang, Baohong Jiang, Xuan Liu, Chunru Cheng, Yifeng Li, Dean Guo*, Comparison of two officinal Chinese pharmacopoeia species of Ganoderma based on chemical research with multiple chromatographic and spectrographic technologies and chemometics analysis, J Chromatogr A, 2012, 1222: 59-70.
10. Jinjun Hou, Wanying Wu*, Juan Da, Shuai Yao, Huali Long, Zhou Yang, Luying Cai, Min Yang, Xuan Liu, Baohong Jiang, Dean Guo*, Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard, J Chromatogr A, 2011, 1218: 5618-5627.
jyjl:北京中医药大学，中药学院，博士
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