姓名： 郭锐华 导师类别： 硕导

所在专业： 食品科学与工程 研究方向： 生物活性化合物研究
学院/单位： 食品学院
专业所属学院： 食品学院
专业技术职务： 讲师 行政职务：
性别： 女 E-Mail： rhguo@shou.edu.cn
最高学位： 博士
通讯地址：
备注：
简历


教育经历

2008.09—2011.07，中国科学院昆明植物研究所，药物化学，博士，
导师：周俊院士、陈纪军研究员
2004.09—2007.06，汕头大学，工业催化，硕士，导师：方奕文教授
2000.09—2004.06，郑州大学，化学工程与工艺，学士

工作经历

2014.08—至今，上海海洋大学，食品学院
2011.07—2014.07，中国人民解放军第二军医大学，药学院，博士后，合作导师：张卫东教授

研究成果

1、国家自然科学基金青年项目，No. **，海洋双吲哚纤溶化合物的结构修饰及其构效关系研究，2015/01-2018/12，21.48万元，在研，支持；
2、上海市创新行动计划，No. **，基于毒理学评价的溶血栓药物先导化合物FGFC1临床前研究，2014/10-2017/09，50万，结题，参与；
3、第51批中国博士后科学基金面上项目，No. 2012M512095，抗炎的倍半萜内酯IF-24的全合成及其构-效关系初探，2012/01-2014/12，5万元、已结题，主持；
4、国家****科学基金，No. **，中药药效物质，2011/01-2014/12，200万，已结题，参加；

获奖情况

2019年获得上海海洋科技术奖二等奖
2018年获得国家海洋局海洋科学技术奖二等奖
2015年获得上海海洋大学教学成果二等奖

专利著作

1. 郭锐华，段东，钱士云，张依婷，王格，包斌，吴文惠. 一种吡喃骈吲哚乙酰化衍生物及其制备方法和应用. 申请号：9.X.
2. 郭锐华，吴文惠，包斌，张依婷，王格，张朝燕. 一种吡喃骈吲哚类化合物及其制备方法和应用. ZL 0.6.
3. 陈纪军，郭锐华，江志勇，罗杰，马云保，周俊，张雪梅. 中国专利：2-(1H)喹啉酮衍生物，其药物组合物及其用途. 授权号：ZL 2.7.
4. 陈纪军，郭锐华, 马云保，江志勇，黄晓燕，罗杰，周俊，张雪梅. 中国专利：喹啉衍生物，其药物组合物及其用途. 授权号：ZL 5.X.

论文发表

1. Jiangming Wang, Changhao Bian, Yinan Wang, Quan Shea, Bin Bao, Junting Fan, Aixue Zuo*, Wenhui Wu*, Ruihua Guo*. Syntheses and bioactivities of songorine derivatives as novel G proteincoupled receptor antagonists, Bioorg. Med. Chem. 2019, 27, 1903
2. Jiangming Wang, Siyuan Su, Shangzhe Zhang, Shiyang Zhai, Ruilong sheng, Wenhui Wu, Ruihua Guo*. Structure-activity relationship of α-santonin derivatives with diverse bioactivities: a mini-review, Eur. J. Med. Chem. 2019, 175, 215.
3. Ruihua Guo, Dong Duan, Shaotong Hong, Yu Zhou, Fang Wang, ShujunWang, Wenhui Wu*, Bin Bao*. A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of A Reciprocal Activation System Based on a Single Chain Urokinase-type Plasminogen Activator and Plasminogen. Process Biochem. 2018, 68, 190.
4. Ruihua Guo, Chengxin Guo, Dan He, Dake Zhao, Yong Shen*. Two New C-19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum. Chin. J. Chem. 2017, 35, 1644.
5. Qinghong Kong, Ting Wu, Yingqi Tang, Lemin Xiong, Hong Liu, Junhao Zhang, Ruihua Guo*, Feng Zhang*. Improving Thermal and Flame Retardant Properties of Epoxy Resin with Organic NiFe-Layered Double Hydroxide-Carbon Nanotubes Hybrids. Chin. J. Chem. 2017, 35, 1875.
6. Ruihua Guo, Yiting Zhang, Dong Duan, Qiang Fu, Xiangyu Zhang, Xiaowei Yu, Shujun Wang, Bin Bao*, Wenhui Wu*. Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216. Chin. J. Chem. 2016, 34, 1194.
7. Ge Wang, Wenhui Wu, Quangang Zhu, Shiqin Fu, Xiaoyu Wang, Shaotong Hong, Ruihua Guo*, Bin Bao*. Identification and Fibrinolytic Activity of an Indolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216. Chin. J. Chem. 2015, 33, 1089.
8. Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen*. Synthesis of Hemslecin A Derivatives: A New Class of Hepatitis B Virus Inhibitors. Bioorg. Med. Chem. Lett. 2013, 23, 1201.
9. Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Jie Luo, Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen*. Structure-Activity Relationships Study of 6-Chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one Derivatives as Novel Non-nucleoside Anti-hepatitis B Virus Agents. Eur. J. Med. Chem. 2011, 46, 307.
10. Rui-Hua Guo, Quan Zhang, Yun-Bao Ma, Jie Luo, Li-Jun Wang, Chang-An Geng, Xue-Mei Zhang, Jun Zhou, Zhi-Yong Jiang, Ji-Jun Chen*. Synthesis and Biological Assay of 4-Aryl-6-chloro-quinoline Derivatives as Novel Non-nucleoside Anti-HBV Agents. Bioorg. Med. Chem. 2011, 19, 1400.
11. Hao Chen, Yun-Bao Ma, Xiao-Yan Huang, Chang-An Geng, Yong Zhao, Li-Jun Wang, Rui-Hua Guo, Wen-Juan Liang, Xue-Mei Zhang, Ji-Jun Chen*. Synthesis, Structure-Activity Relationships and Biological Evaluation of Dehydroandrographolide and Andrographolide Derivatives as Novel Anti-hepatitis B virus Agents. Bioorg. Med. Chem. Lett. 2014, 24, 2353.
12. Chang-An Geng, Li-Jun Wang, Rui-Hua Guo, Ji-Jun Chen*. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents. Mini-Rev. Med. Chem. 2013, 13, 749.
13. Li-Jun Wang, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Hao Chen, Rui-Hua Guo, Xue-Mei Zhang, Ji-Jun Chen*. Synthesis, Structure-activity Relationships and Biological Evaluation of Caudatin Derivatives as Novel Anti-hepatitis B Virus Agents. Bioorg. Med. Chem. 2012, 20, 2877.
14. Chang-An Geng, Li-Jun Wang, Xue-Mei Zhang, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Rui-Hua Guo, Jun Zhou, Yong Shen, Ai-Xue Zuo, Zhi-Yong Jiang, Ji-Jun Chen*. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis. Chem. Eur. J. 2011, 17, 3893.
15. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma, Ji-Feng Liu, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Wei Niu, Fei-Fe Du, Li Li, Chuan Li, Ji-Jun Chen*. Anti-HBV Agents. Part 3: Discovery and Preliminary Structure-activity Relationships of tetra-Acetyl-alisol A as a Highly Potent Anti-hepatitis B Virus Inhibitor. Bioorg. Med. Chem. Lett. 2009, 19, 6659.
16. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Ji-Feng Liu, Yun-Bao Ma, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen*. Anti-HBV Agents. Part 2: Synthesis and in vitro Anti-hepatitis B Virus Activities of Alisol A Derivatives. Bioorg. Med. Chem. Lett. 2009, 19, 2148.
17. Hao Chen, Guozhen Wu, Shuang Gao, Ruihua Guo, Zeng Zhao, Hu Yuan, Shanxiang Liu, Jian Wu, Xiaolong Lu, Xing Yuan, Zongmin Yu, Xianpeng Zu, Ning Xie, Niao Yang, Zhenlin Hu*, Qingyan Sun*, and Weidong Zhang*. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α?Santonin Derivatives. J. Med. Chem. 2017, 60, 6828.