姓名：温文玉 博士
职称：研究员
E-MAIL: wywen@fudan.edu.cn
WWW: http://ibs.fudan.edu.cn/peoplemore.php?id=189&tid=1
研究方向
1.神经早期发育的分子机制
2.神经信号传导分子机制
重要学术贡献
温文玉研究员长期致力于研究神经早期发育及神经信号转导过程中重要调控蛋白质的作用机理，以及其与神经系统疾病（如脑肿瘤）的关联性。在Cell, Molecular Cell, Nature Communications, EMBO J, EMBO Reports等杂志发表SCI 论文26篇，被引760余次。近期代表性工作如下：比较系统地研究了神经干细胞不对称分裂过程的分子机制，率先提供了LGN依赖性的纺锤体转向力产生系统的组装机理，并修正了原有模型；发现蛋白质的相变调控了细胞命运决定因子极性聚集进而促使神经干细胞分化；提出了支架蛋白INAD 主动调节自身氧化还原电势进而介导视觉信号传导过程的新机制。
荣誉与获奖
2014 国家自然科学基金委优秀青年科学基金
2012 教育部新世纪优秀人才
2016 上海市委组织部青年拔尖人才
2014 上海市教委曙光****
2010 上海市科委青年科技启明星
国内外学术团体任职
2014-今 中国生物物理学会生物磁共振专业委员会理事
2015-今 中国生物物理学会女科学家分会理事
受邀审稿学术刊物
2017 Nature Communications
2017 elife
受邀学术报告
2017 “Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch”， 华东地区生物化学与分子生物学学会联合会2017年学术交流会，安徽合肥
2017 “HECT E3 Itch: Mechanisms of Regulation and Activation”，第二届全国生物磁共振研讨会，山东青岛
2017 “Phase transition-mediated Numb/Pon complex basal condensation during Drosophila neuroblast asymmetric division”，中国细胞生物学学会2017年全国学术大会，福建厦门
2016 “Structural studies of asymmetric cell division of neural stem cells”, The 5th International Conference and the 2nd ASCB Local Meeting on Cellular Dynamics and Chemical Biology, Hefei, China
2016 “Asymmetric Cell Division of Neural Stem Cells”, Symposium on Structural Biology of Neuronal Development and Signaling, Hong Kong, P. R. China
2016 “Asymmetric Cell Division: Implications for Glioma Development and Treatment”，2016上海华山国际脑胶质瘤高峰论坛，上海
2013 “Structural basis for LGN-mediated spindle orientation in asymmetric cell division”，第一届国际暨第十三次中国生物物理学术大会，江西南昌
发表论文
1.Shan, Z., Tu, Y., Yang, Y., Liu, Z., Zeng, M., Xu, H., Long, J., Zhang, M., Cai, Y.*, and Wen, W.* “Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division” Nat. Commun. (2018) 9:737, doi: 10.1038/ s41467-018-03077-3.
2.Chen, X., Liu, Z., Shan, Z., Yao, W., Gu, A., and Wen, W.* “Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/α-adaptin complex” J. Biol. Chem. (2018) doi:10.1074/ jbc.RA117.000897.
3.Zhu, K., Shan, Z., Chen, X., Cai, Y., Cui, L., Yao, W., Wang, Z., Shi, P., Tian, C., Lou, J., Xie, Y., and Wen, W.* “Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch” EMBO Rep. (2017) 18, 1618-1630.
4.Zhu, K., Shan, Z., Zhang, L., and Wen, W.* “Phospho-Pon binding mediated fine-tuning of Plk1 activity” Structure (2016) 24, 1110-1119.
5.Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z.-G., Zhang, M., Cai, Y.*, Wen, W.*, and Wang, W.* “The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division” Nat. Commun. (2015) 6:8381, doi: 10.1038/ncomms9381.
6.Pan, Z., Shang, Y., Jia, M., Zhang, L., Xia, C., Zhang, M., Wang, W.*, and Wen, W.* “Structural and biochemical characterization of the interaction between LGN and Frmpd1” J. Mol. Biol. (2013) 425, 1039-1049.
7.Zhu, J., Shang, Y., Xia, C., Wang, W., Wen, W.*, and Zhang, M.* “Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules” EMBO J. (2011) 30, 4986-4997.
8.Liu, W.#, Wen, W.#, Wei, Z., Yu, J., Ye, F., Liu, C.-H., Hardie, R.C., and Zhang, M. “The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye” Cell (2011) 145, 1088-1101. (#: co-first authors) (Cover article)
9.Zhu, J.#, Wen, W.#, Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du, Q., Wang, W., and Zhang, M. “LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways” Mol. Cell (2011) 43, 418-431. (#: co-first authors)
10.Wen, W., Yu, J., Pan, L., Wei, Z., Weng, J., Wang, W., Ong, Y.S., Hoai, T.T.T., Hong, W., and Zhang, M. “Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6” Mol. Cell (2010) 37, 383-395.