姓名：于敏 博士
职称：教授
E-MAIL: minyu@shmu.edu.cn


研究方向
1.基于蛋白质构效关系设计研制生物技术新药，主要从事人源化抗PD-1及C-Met双特异性单克隆抗体的分子设计与研制。
2.Brd2在能量代谢中的调节作用及机制的研究。
重要学术贡献（300字以内）
荣誉与获奖
国内外学术团体任职
2008-今 上海生物工程学会 常务理事
2008-2015 中国药物生物技术协会 理事
受邀审稿学术刊物
2008-今 药物生物技术 编辑
2016-今 Protein and Peptide Letters 编辑
发表论文
1.Zu-Jun Sun, Yi Wu, Wei-Hua Hou, Yu-Xiong Wang, Qing-Yun Yuan, Hui-Jie Wang, Min Yu. A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer Oncotarget. 2017, Vol. 8, (No. 17), pp: 29067-29079
2.Ruixin Sun, Yi Wu, Weihua Hou, Zujun Sun, Yuxiong Wang, Huanhuan Wei, Wei Mo, Min Yu*.Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue. Cell Signal. 2016 ;30:92-103
3.Ruixin Sun, Yi Wu, Yuxiong Wang, Kun Zang, Huanhuan Wei Min Yu* DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation. Mol Cell Biochem. 2015, 402(1-2):23-31.
4.Rongzeng Liu, Bin Zhao, Yanling Zhang, Junxiang Gu, Mingrong Yu Houyan Song, Min Yu Wei Mo High-level expression, purification, and enzymatic characterization of truncated human plasminogen(Lys531-Asn791) in the methylotrophic yeast Pichia pastoris. BMC Biotechnol. 2015, 15:50
5.Yinong Huang, Yanling Zhang, Bing Zhao,Houyan Song Min Yu and Wei Mo Structural basis of RGD-hirudin binding tothrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activityBMC Structural Biology (2014) 14:26
6.Yongjiang Lang ,Yanling Zhang, Ling Zhan, Zhe Feng, Xiushi Zhou, Min Yu*, and Wei Mo Expression, purification, and characterization of rhTyrRS BMC Biotechnology 2014, 14:64
7.Ling Zhan, Yanling Zhang, Min Yu* Wei Mo Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent.Eur J Pharmacol. 2014 738,293-300
8.Yushan Liu, Chensheng Wu, Jingyu Wang，Wei Mo, MinYu*. Codon optimization, expression, purification, and functional characterization of recombinant human IL-25 in Pichia pastoris. Appl Microbiol Biotechnol. 2013, 97(24):10349-58
9.Kun Zang, Jingyu Wang, Miaofang Dong, Ruixin Sun, Yuxiong Wang, Yinong Huang, Xiaoxia Liu, Yimin Li, Fangnian Wang,* and Min Yu*Brd2 Inhibits Adipogenesis via the ERK1/2 Signaling Pathway in 3T3-L1 Adipocytes. PLoS One. 2013, 8(10):e78536.
10.Renquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo1, Huijie Wang, Jianbo Ding, Eric T Wong and Min Yu* The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo.BMC Cancer 2012, 12:607
申请或授权专利
授权专利
1.莫炜; 黄一农; 于敏; 张艳玲, 直接凝血酶抑制剂多肽及其用途, 2013.04.14,
中国, ZL8.2
申请专利
1.于敏 ; 孙祖俊; 吴毅; 王羽雄; 莫炜, 双特异性嵌合抗原受体c-Met/Pd-1
scFv-Car-T及其构建方法和应用, 2017.08.28, 中国, 2.1
2 于敏 ; 吴毅; 王羽雄, 人源化抗PD-1及c-Met双特异性抗体及其制备方法和应用, 2014.05.23, 中国, 2.9