傅俊杰
职称：副教授、硕士生导师
学历/学位：研究生、博士
电话：
电子邮箱：jfu@jiangnan.edu.cn


简介
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依托江南大学生物工程学院“轻工技术与工程”一流学科、糖化学与生物技术教育部重点实验室，主要从事糖类药物，特别是靶向性糖类前药和糖尿病治疗药物的研究。近年来以第一作者或通讯作者身份在Chem Sci、Chem Commun、J Med Chem、Eur J Med Chem、Brit J Pharmaol等国际权威期刊发表SCI论文20余篇；申请中国发明专利7件，授权1件；主持国家自然科学基金青年基金、江苏省自然科学基金青年基金等项目6项；承担生物工程学院《糖生物工程》（卓越课）、《糖化学》、《科技论文写作》等课程的讲授。



学习工作经历
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2004-2008 中国药科大学，制药工程专业，工学学士
2008-2013 中国药科大学，药物化学专业，理学博士
2013-2015 美国佛罗里达大学，药物化学专业，博士后
2015-2018 南京医科大学，药学院，副教授、硕士生导师
2019-至今 江南大学，生物工程学院，副教授、硕士生导师



主要成果
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一、论文（论著）发表情况
部分代表性论文如下：
1. Han, J.^#; Fu, J.^#; Yang, Q.; Zhou, F.; Chen, X.; Li, C.; Yin, J.^* Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents. Eur. J. Med. Chem. 2020, accetped
2. Meng, T.; Han, J.; Zhang, P.; Hu, J.; Fu, J.^*; Yin, J.^* Introduction of the α-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs. Chem. Sci. 2019, 10, 7156-7162.
3. Han, J.; Meng, T.; Chen, X.; Han, Y.; Fu, J.^*; Zhou, F.; Fei, Y.; Li, C.^* The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogs xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models. FASEB J. 2019, 33, 7113-7125.
4. Fu, J.^#; Han, J.^#; Meng, T.; Hu, J.; Yin, J.^* Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity. Chem. Commun. 2019, 55, 12904-12907.
5. Han, J.^*; Zhou, F.; Fei, Y.; Chen, X.; Fu, J.^*; Qian, H.^* Preparation and Pharmaceutical Characterizations of Lipidated Dimeric Xenopus Glucagon-Like Peptide-1 Conjugates. Bioconjugate Chem. 2018, 29, 390-402.
6. Han, J.^*; Fei, Y.; Zhou, F.; Chen, X.; Zhang, Y.; Liu, L.; Fu, J.^* Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities. Br. J. Pharmacol. 2018, 175, 544-557.
7. Han, J.^*; Chen, X.; Zhao, L.; Fu, J.^*; Sun, L.; Zhang, Y.; Zhou, F.; Fei, Y. Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs. Mol Pharmaceut 2018, 15, 2840-2856.
8. Huang, Z.^#; Fu, J.^#; Zhang, Y.^* Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects. J. Med. Chem. 2017, 60, 7617-7635.
9. Han, J.^*; Wang, Y.; Meng, Q.; Li, G.; Huang, F.; Wu, S.; Fei, Y.; Zhou, F.; Fu, J.^* Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. Eur. J. Med. Chem. 2017, 132, 81-89.
10. Han, J.^*; Fei, Y.; Zhou, F.; Chen, X.; Zheng, W.; Fu, J.^* Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes. Mol Pharmaceut 2017, 14, 3954-3967.
11. Han, J.^*; Chen, X.; Wang, Y.; Fei, Y.; Zhou, F.; Zhang, Y.; Liu, L.; Si, P.; Fu, J.^* Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. Biochem. Pharmacol. 2017, 142, 155-167.
12. Fu, J.; Khaybullin, R.; Zhang, Y.; Xia, A.; Qi, X.^* Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression. BMC Cancer 2015, 15, 473.
13. Fu, J.; Lee, T.; Qi, X.^* The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening. Future Med Chem 2014, 6, 809-823.
14. Fu, J.^#; Liu, L.^#; Huang, Z.^#; Lai, Y.; Ji, H.^*; Peng, S.; Tian, J.; Zhang, Y.^* Hybrid molecule from O²-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: A glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability. J. Med. Chem. 2013, 56, 4641-4655.
15. Huang, Z.^#; Fu, J.^#; Liu, L.; Sun, Y.; Lai, Y.; Ji, H.; Knaus, E. E.; Tian, J.; Zhang, Y.^* Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Org. Biomol. Chem. 2012, 10, 3882-3891.
二、专利情况
申请中国专利7件，授权1件
三、承担教学科研项目情况
1、江南大学基本科研计划青年基金，2020.01—2021.12
2、国家自然科学基金青年项目，2017.01—2019.12
3、江苏省自然科学基金青年项目，2016.07—2019.06
4、江苏省高校自然科学研究面上项目，2016.09—2018.08
5、中国药科大学天然药物活性组分与药效国家重点实验室开放课题，2017.01—2018.12
6、南京医科大学引进人才科研启动基金，2015.12—2018.12
7、江南大学2019年本科教育教学改革研究项目教师卓越工程专项
四、获奖情况（含指导学生获奖）
2019年江南大学生物工程学院青年教师会讲比赛一等奖
以上资料更新时间截止：2020年4月