Rossa Chiu 赵慧君
Professor of Chemical Pathology 化学病理学讲座教授

rossachiu@cuhk.edu.hk


Biography
Rossa Chiu is Professor of Chemical Pathology and Associate Dean (Development) at the Faculty of Medicine, The Chinese University of Hong Kong. She is an Honorary Consultant Chemical Pathologist at the New Territories East Cluster of Hospitals. Prof Chiu graduated from medical school at the University of Queensland, Australia and was awarded Doctor of Philosophy by The Chinese University of Hong Kong. She is a Fellow of the Royal College of Pathologists of Australasia, the Hong Kong College of Pathologists and the Hong Kong Academy of Medicine (Pathology).


Prof Chiu's research interests lie in the analysis of circulating nucleic acids found in human plasma. She has made significant contributions to the development of non-invasive prenatal diagnosis which led to the worldwide introduction of non-invasive plasma DNA tests for Down syndrome screening. Recently, she has been investigating the detection of cancer-derived DNA in human plasma with an aim to develop non-invasive blood tests for cancer detection.







To date, Prof Chiu has published over 140 peer-reviewed research articles and has over 150 granted patents. Prof Chiu has received a number of awards for her research, including the 2011 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Young Investigator Award, the 2012 China Women in Science Fellowship and the 2013 American Association of Clinical Chemistry Outstanding Scientific Contributions for a Young Investigator. She is currently a member of the Board of Directors of the International Society of Prenatal Diagnosis and co-Chair of the Federation of the International Society of Prenatal Diagnosis. She was the President of the Hong Kong Society of Clinical Chemistry from 2004 to 2005.



Specialised Research Area(s):
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Development of non-invasive prenatal diagnostic approaches
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Development of non-invasive cancer diagnostic approaches
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Clinical applications of circulating nucleic acid analysis
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Understanding of the biology of circulating nucleic acids
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Development of novel molecular diagnostic strategies and innovative applications of molecular analysis tools



Selected Publications:

1. Sun K, Jiang P, Chan KCA, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RWY, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PBS, Chiu RWK and Lo YMD (2015). Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci U S A 112: E5503-12.

2. Cheng SH, Jiang P, Sun K, Cheng YK, Chan KCA, Leung TY, Chiu RWK and Lo YMD (2015). Noninvasive Prenatal Testing by Nanopore Sequencing of Maternal Plasma DNA: Feasibility Assessment. Clin Chem 61: 1305-6.

3. Benn P, Borrell A, Chiu RWK, Cuckle H, Dugoff L, Faas B, Gross S, Huang T, Johnson J, Maymon R, Norton M, Odibo A, Schielen P, Spencer K, Wright D and Yaron Y (2015). Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis. Prenat Diagn 35: 725-34.

4. Hudecova I, Sahota D, Heung MM, Jin Y, Lee CWS, Leung TY, Lo YMD, Chiu RWK (2014). Maternal plasma fetal DNA fractions in pregnancies with low and high risks for fetal chromosomal aneuploidies. PLoS One 9, e88484

5. Lun FMF, Chiu RWK, Sun K, Leung TY, Jiang P, Chan KCA, Sun H and Lo YMD (2013). Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA. Clin Chem. 59, 1583-94.

6. Yu SCYJ, Jiang P, Choy KW, Chan KCA, Won HS, Leung WC, Lau ET, Tang MH, Leung TY, Lo YMD and Chiu RWK (2013). Noninvasive prenatal molecular karyotyping from maternal plasma. PLoS One 8, e60968.

7. Chiu, RWK, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KCA, Lun FMF, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YMD (2011). Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ 342, c7401.

8. Chiu RWK, Chan KCA, Gao Y, Lau VYM, Zheng W, Leung TY, Foo CH, Xie B, Tsui NBY, Lun FMF, Zee BC, Lau TK, Cantor CR, Lo YMD (2008). Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A 105, 20458-63.

9. The Chinese SARS Molecular Epidemiology Consortium (2004). Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science 303, 1666-1669. (Equal first author)

10. Chiu RWK, Lau TK, Leung TN, Chow KCK, Chui DHK and Lo YMD (2002). Prenatal exclusion of beta thalassaemia major by examination of maternal plasma. Lancet 360, 998-1000.