Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李汉良教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S1542-0124(12)70093-9 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/7Scopus source URL
其它资讯
摘要Glutathione (GSH) is an abundant antioxidant ubiquitous in nearly all cell types. Deficiency of GSH has been linked to ocular disease and viral infection. Other established vital roles of GSH include detoxification and immunoprotection. Endogenous GSH plays a protagonist's role in safeguarding active transport processes compartmentalized at the interface between conjunctival mucosa and the tear film. Optimal electrokinetic transport across the conjunctival epithelium requires the mucosal presence of GSH. Glutathione is the most abundant known endogenous antioxidant molecule in tear fluid, mainly derived from conjunctival secretion. Conjunctival GSH transport, a major kinetic component of GSH turnover, occurs through multiple functionally distinct mechanisms. Cell membrane potential regulates conjunctival GSH efflux, while conjunctival GSH uptake requires extracellular Na+. Significant modulation of GSH, its constituent amino acids, and functions of associated transporters occurs in the conjunctival epithelium with viral inflammatory disease. Topical conjunctival delivery of GSH, its metabolic precursors, or pharmacologic stimulation of endogenous conjunctival GSH secretion carry potential in alleviating viral-inflammatory conjunctivitis. ? 200http://aims.cuhk.edu.hk/converis/portal/Publication/7 Ethis Communications, Inc.
着者Gukasyan H.J., Kim K.-J., Lee V.H.L., Kannan R.
期刊名称Ocular Surface
出版年份200http://aims.cuhk.edu.hk/converis/portal/Publication/7
月份10
日期1
卷号5
期次4
出版社Ethis Communications
出版地United States
页次269 - 2http://aims.cuhk.edu.hk/converis/portal/Publication/79
国际标準期刊号1542-0124
电子国际标準期刊号193http://aims.cuhk.edu.hk/converis/portal/Publication/7-5913
语言英式英语
关键词Cysteine/cystine, Cystic fibrosis transmembrane conductance regulator protein (CFTR), Epithelial transport mechanisms, Glutathione (GSH), Ocular surface defense, Oxidative stress
