Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/jps.20950 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
其它资讯
摘要Hydrogels are a continuously expanding class of pharmaceutical polymers designed for sustained or controlled drug release. The structure and intermolecular interactions in such systems define their macroscopic properties. The aim of this study was to investigate the mechanism of swelling, drug impregnation, and drug release from poly(ethylene oxide) (PEO) gel crosslinked by urethane bonds. A combination of SAXS/WAXS/SANS techniques enabled us to determine the phase transition between lamellar and extended gel network, and to apply different descriptions of crystallinity, based on lamellar and crystal lattice structures. It is shown that even low (1-7% w/w) loading of model drugs acetaminophen and caffeine, produced significant disorder in the polymer matrix. This effect was particularly pronounced for acetaminophen due to its specific ability to form complexes with PEO. The drug-release profiles were analyzed using a general cubic equation, proposed for this work, which allowed us to determine the gel hydration velocity. The results indicate that the release profiles correlate inversely with the polymer crystallinity. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.
着者Shekunov BY, Chattopadhyay P, Tong HHY, Chow AHL, Grossmann JG
期刊名称JOURNAL OF PHARMACEUTICAL SCIENCES
出版年份2007
月份5
日期1
卷号96
期次5
出版社JOHN WILEY & SONS INC
页次1320 - 1330
国际标準期刊号0022-3549
电子国际标準期刊号1520-6017
语言英式英语
关键词atomic force microscopy (AFM); drug loading; hydration; poly(ethylene oxide) gels; polymer crystallinity; release; small- and wide-angle X-ray scattering (SAXS/WAXS); small-angle neutron scattering (SANS)
Web of Science 学科类别Chemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
