Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄家星教授 (内科及药物治疗学系) |
| 吴浩强教授 (病理解剖及细胞学系) |
| 胡锦生教授 |
| 陈向燕教授 (内科及药物治疗学系) |
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1177/0891988706298627 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
其它资讯
摘要Environmental and genetic factors may both affect the risk of vascular cognitive impairment developing after a stroke. To identify factors affecting this risk, the cognitive status of 121 patients was examined 3 months after an ischemic stroke. In all patients and in 2http://aims.cuhk.edu.hk/converis/portal/Publication/70 control subjects, http://aims.cuhk.edu.hk/converis/portal/Publication/7 polymorphisms reported to affect risk of vascular ischemic disease were genotyped. In 51 patients (42.1%), vascular cognitive impairment resulted, defined by a Mini-Mental State Examination score of less than 24. These patients were older and more likely to be women. Alleles of none of the polymorphisms differed between patients with or without vascular cognitive impairment, except for glutamate-cysteine ligase modifier (GCLM) (odds ratio = 2.8, P =.006). When all stroke patients were considered, the GCLM genotype did not affect Mini-Mental State Examination scores. Testing the GCLM genotype in an independent group of stroke patients may determine whether this association with vascular cognitive impairment is genuine.
着者Baum L, Chen XY, Cheung WS, Cheung CKA, Cheung LW, Chiu KFP, Wen HM, Poon P, Woo KS, Ng HK, Wong KS
期刊名称Journal of Geriatric Psychiatry and Neurology
出版年份200http://aims.cuhk.edu.hk/converis/portal/Publication/7
月份6
日期1
卷号20
期次2
出版社SAGE PUBLICATIONS INC
页次93 - 99
国际标準期刊号0891-988http://aims.cuhk.edu.hk/converis/portal/Publication/7
电子国际标準期刊号1552-5http://aims.cuhk.edu.hk/converis/portal/Publication/708
语言英式英语
关键词apolipoprotein E; dementia; glutamate-cysteine ligase modifier; ischemic stroke; lipoprotein lipase
Web of Science 学科类别Clinical Neurology; CLINICAL NEUROLOGY; Geriatrics & Gerontology; GERIATRICS & GERONTOLOGY; Neurosciences & Neurology; Psychiatry; PSYCHIATRY, SCI
