Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林革教授 (生物医学学院) |
| 左中教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1021/mp700077z |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/92WOS source URL
其它资讯
摘要Flavonoids are polyphenolic phytochemicals present extensively in our daily diets, beverages, medicinal plants, and herbal remedies. The diverse biological effects of flavonoids have aroused great interest in scientists. In the past decade, various studies demonstrated extensive conjugate metabolisms, especially glucuronidation, of flavonoids in intestine and liver implying an important role of the glucuronidation in causing low oral bioavailability of flavonoids. The present article aims to review the up-to-date information On the studies of the first-pass metabolism, in particular glucuronidation, of flavonoids in the gastrointestinal tract and the liver, and also the isoformic enzymes involved in the metabolism and disposition of flavonoids. In addition, the role of efflux transporters, enterohepatic circulation, and enteric cycling in the disposition of flavonoid glucuronides has also been illustrated. Despite low oral bioavailabilities of the parent compounds, flavonoids and some of their bioactive phase II conjugates may accumulate adequate amount in the body to produce their pharmacological activities. Further investigation on the correlation between the accumulated concentrations of flavonoids and their pharmacological activities after their repeated oral administration is warranted.
着者Zhang L, Zuo Z, Lin G
期刊名称MOLECULAR PHARMACEUTICS
出版年份2007
月份11
日期1
卷号4
期次6
出版社AMER CHEMICAL SOC
页次833 - 845
国际标準期刊号1543-8384
语言英式英语
关键词first pass metabolism; flavonoids; glucuronidation
Web of Science 学科类别Medicine, Research & Experimental; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Research & Experimental Medicine
