Particle engineering for pulmonary drug delivery
Publication in refereed journal


香港中文大学研究人员 ( 现职)

周喜林教授 (药剂学院)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1007/s11095-006-9174-3

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/274WOS source URL

其它资讯

摘要With the rapidly growing popularity and sophistication of inhalation therapy, there is an increasing demand for tailor-made inhalable drug particles capable of affording the most efficient delivery to the lungs and the most optimal therapeutic outcomes. To cope with this formulation demand, a wide variety of novel particle technologies have emerged over the past decade. The present review is intended to provide a critical account of the current goals and technologies of particle engineering for the development of pulmonary drug delivery systems. These technologies cover traditional micronization and powder blending, controlled solvent crystallization, spray drying, spray freeze drying, particle formation from liquid dispersion systems, supercritical fluid processing and particle coating. The merits and limitations of these technologies are discussed with reference to their applications to specific drug and/or excipient materials. The regulatory requirements applicable to particulate inhalation products are also reviewed briefly.

着者Chow AHL, Tong HHY, Chattopadhyay P, Shekunov BY
期刊名称PHARMACEUTICAL RESEARCH
出版年份2007
月份3
日期1
卷号24
期次3
出版社SPRINGER/PLENUM PUBLISHERS
页次411 - 437
国际标準期刊号0724-8741
电子国际标準期刊号1573-904X
语言英式英语

关键词aerosols; crystalline and amorphous solids; inhalers; micro- and nanoparticles; micronization; particle size; respiratory drug delivery; spray drying; spray freeze drying; supercritical fluids
Web of Science 学科类别Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY