Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0021-8502(03)00022-3 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/58WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/60Scopus source URL
其它资讯
摘要Comparative analysis of salmeterol xinafoate (SX) powders was carried out to define the aerodynamic properties and mechanism of particle dispersion relevant to the use of these materials in dry powder inhalation drug delivery. Particle sizing methodology was evaluated using laser diffraction, time-of-flight and Andersen cascade impactor measurements combined with electron microscopy and surface area determination. Particle interactions, assessed on the basis of powder bulk density and inverse gas chromatography surface energy measurements, were compared with the aerodynamic forces generated by a dry-powder dispersion device. The supercritically produced material showed by a factor of seven reduced tensile strength of the aggregates and indicated a two-fold increase of fine particle fraction deposited in a cascade impactor when blended with lactose. This effect was explained by the reduced particle aggregation at low differential air pressures and flow rates. A relatively small value of aerodynamic stress required to disperse supercritically produced particles in comparison to micronized material comes from: (a) lower bulk density (loose aggregate structure), (b) larger volume mean diameter, (c) larger aerodynamic shape factor and (d) smaller specific free energy of S-SX particles, in this order of priority. It is shown that aggregation between primary drug particles is important for SX/lactose formulations because such aggregates survive the pre-separation impactor stage. ? 2003 Elsevier Science Ltd. All rights reserved.
着者Shekunov B.Y., Feeley J.C., Chow A.H.L., Tong H.H.Y., York P.
期刊名称Journal of Aerosol Science
出版年份2003
月份5
日期1
卷号34
期次5
出版社Pergamon Press Ltd.
出版地United Kingdom
页次553 - 568
国际标準期刊号0021-8502
语言英式英语
关键词Dry powder inhalers, Respiratory drug delivery, Supercritical fluid crystallization
