Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈维智博士 (药剂学院) |
| 凌美麟教授 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/jac/dkg167 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
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摘要This study was initiated throughout Hong Kong, to reveal the characteristics of community-acquired infections. All specimens collected by general practitioners from infected patients were followed prospectively, and those that were culture-positive were analysed. Four thousand seven hundred and forty-one specimens were collected from 3977 patients by 89 doctors from July 2000 to October 2001. The most common specimens were throat swabs (33%), urine (26%) and sputa (16%). The average culture-positive rate was 28%. The most common organisms were Escherichia coli (18%), beta-haemolytic streptococci (1http://aims.cuhk.edu.hk/converis/portal/Publication/5%) and Staphylococcus aureus (12%). Fluoroquinolone resistance was relatively high (up to 3http://aims.cuhk.edu.hk/converis/portal/Publication/5%) in organisms commonly causing urinary tract infection (E. coli, Proteus and Morganella). Although none of the pneumococci was resistant to penicillin 1 mg/L, the proportion with intermediate resistance (0.1-1 mg/L) was alarming (81%). There were three strains of methicillin-resistant S. aureus. A decrease in ampicillin resistance but a high prevalence of macrolide resistance were noted in Haemophilus influenzae. All Neisseria gonorrhoeae isolates were resistant to penicillin, up to 79% to the fluoroquinolones, 1http://aims.cuhk.edu.hk/converis/portal/Publication/5% to spectinomycin, but all were susceptible to ceftriaxone. Respiratory pathogens (Streptococcus pneumoniae, P-haemolytic streptococci and H. influenzae) were relatively susceptible to the newer fluoroquinolones (0-2%, 0.http://aims.cuhk.edu.hk/converis/portal/Publication/5-6% and 2% resistant, respectively) or third-generation cephalosporins (0-2% resistant). The distribution of organisms and their antibiotic resistance varied over time. Thus frequent surveillance is needed to provide information on the drugs of choice for different infections.
着者Ling JM, Lam AW, Chan EW, Cheng AE
期刊名称Journal of Antimicrobial Chemotherapy
出版年份2003
月份4
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/51
期次4
出版社OXFORD UNIV PRESS
页次89http://aims.cuhk.edu.hk/converis/portal/Publication/5 - 904
国际标準期刊号030http://aims.cuhk.edu.hk/converis/portal/Publication/5-74http://aims.cuhk.edu.hk/converis/portal/Publication/53
电子国际标準期刊号1460-2091
语言英式英语
关键词antimicrobial susceptibilities; community-acquired infections
Web of Science 学科类别Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
