Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周柽森教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1054/jelc.2001.22032 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL
其它资讯
摘要This article evaluates the antifibrillatory effects of carvedilol 5 mg/kg and vehicle (dimethyl-formamide) over time. Sprague-Dawley rats were anesthetized and intubated. They underwent baseline ventricular fibrillation threshold (VFT) determination and then received I of the 2 treatments (n = http://aims.cuhk.edu.hk/converis/portal/Publication/10/group) over 8 minutes. VFT and determinations were performed at 2, 7, http://aims.cuhk.edu.hk/converis/portal/Publication/15, 30, 45, and 60 minutes postinfusion. Carvedilol significantly increased the VFT at 2, 7, http://aims.cuhk.edu.hk/converis/portal/Publication/15, 30 minutes versus baseline and the vehicle control group. Carvedilol significantly reduced the heart rate and the mean arterial pressure at every evaluable time point versus baseline and vehicle control. Carvedilol showed significant antifibrillatory effects versus baseline and vehicle for the first 30 minutes but not thereafter, even though the heart rate and mean arterial pressure remain significantly reduced.
着者Xie JL, Dunn A, Tsikouris JP, Sun YL, Fan CD, Kluger J, Chow MSS, White CM
期刊名称Journal of Electrocardiology
出版年份200http://aims.cuhk.edu.hk/converis/portal/Publication/1
月份http://aims.cuhk.edu.hk/converis/portal/Publication/1
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号34
期次http://aims.cuhk.edu.hk/converis/portal/Publication/1
出版社CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
页次25 - 30
国际标準期刊号0022-0736
语言英式英语
关键词antifibrillatory; beta-blockers; carvedilol; VFT
Web of Science 学科类别Cardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology
