Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1021/cg034026o |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/17WOS source URL
其它资讯
摘要Acetaminophen (A) and p-acetoxyacetanilide (PAA) were used as model drug substances to study purification and coformulation of structurally similar molecules by crystallization from supercritical CO2. Incorporation of PAA into the crystal structure of A was defined by the mutual solubility of crystals of both molecules according to their different solvent-solute interactions, by the thermodynamics of the A-PAA solid solution phase, and by the kinetics of crystallization reflected by the specific surface interactions. The interaction between PAA and A resulted in significant changes to the crystal bulk and surface free energy, particle size, and morphology. Accurate determination of the lattice constants revealed the formation of a secondary A-PAA phase with a deformed crystal lattice. The observed changes in the thermal behavior of the resulting solid solutions are explained mainly by changes of the entropy of the solid phase with smaller changes in enthalpy and even smaller elastic energy contributions.
着者Shekunov BY, Bristow S, Chow AHL, Cranswick L, Grant DJW, York P
期刊名称Crystal Growth and Design
出版年份2003
月份7
日期1
卷号3
期次4
出版社AMER CHEMICAL SOC
页次603 - 610
国际标準期刊号1528-7483
电子国际标準期刊号1528-7505
语言英式英语
Web of Science 学科类别Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Crystallography; CRYSTALLOGRAPHY; Materials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY
