Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 汤宁信教授 |
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1034/j.1399-0004.2003.00063.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/66WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/75Scopus source URL
其它资讯
摘要A new apolipoprotein gene, APOA5, was recently discovered near the APOA1/C3/A4 gene cluster. Transgenic mice overexpressing the homologous gene, apoa5, showed reduced plasma triglyceride levels, while knockout mice had greatly increased triglycerides, suggesting that human genetic variants affecting expression of the protein product, APOAV, might affect triglyceride levels. Polymorphisms in the APOA5 gene were indeed found to be associated with triglyceride levels in men, though not in women. We sought to confirm the association of the APOA5-1131T>C polymorphism with triglyceride levels in 167 Chinese men chosen for having either high (≥ 1.7 mM, n = 82) or low (≤ 1.2 mM, n = 85) triglycerides. More subjects with high triglycerides had one or two copies of the minor (C) allele of the polymorphism (67%) than did low triglyceride subjects (48%), and combining all subjects showed that those with one or two C alleles had higher triglyceride levels [1.67±2.20 (geometric mean ± SD)] than those without (1.22 ± 2.08 mM, p = 0.01), confirming the reported effect in a different ethnic group. The C allele is more common in Chinese than in Caucasians (26-40 vs. 8% of alleles), suggesting that the impact of this polymorphism on triglyceride levels in the population and therefore on public health is greater among Chinese.
着者Baum L., Tomlinson B., Thomas G.N.
期刊名称Clinical Genetics
出版年份2003
月份5
日期1
卷号63
期次5
出版社Blackwell Publishing Inc.
出版地United Kingdom
页次377 - 379
国际标準期刊号0009-9163
电子国际标準期刊号1399-0004
语言英式英语
关键词Apolipoprotein, Genetic, Lipid, Lipoprotein, SNP
