Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 彭智培教授 (眼科及视觉科学学系) |
| 包立怡教授 (药剂学院) |
| 范舒屏教授 (眼科及视觉科学学系) |
| 谭霭仙女士 (儿科学系) |
| 林顺潮教授 (外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000068554 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/30WOS source URL
其它资讯
摘要A locus for autosomal dominant high myopia was reported on chromosome 18p. We sought to confirm this finding and narrow the reported interval by analyzing high myopia among families of Hong Kong Chinese, in whom myopia is common. In 15 families with a possibly autosomal dominant inheritance of high myopia (greater than or equal to -6 dpt) in at least 2 generations, 10 chromosome 18p markers were analyzed for linkage with high myopia. Two-point linkage analysis showed trends toward linkage of markers D18S476 and D18S62 with high myopia, with maximum logarithm of odds (LOD) scores of at least 1.1 and 1.7, respectively. Multipoint analysis of those 2 markers gave a maximum LOD score of at least 2.1. To attempt to account for likely genetic heterogeneity, 5 families showing evidence of linkage of the 2 markers with high myopia were selected for further multipoint linkage analysis, resulting in a maximum LOD score of 2.4 at D18S476. While multiple genetic and environmental factors likely contribute to myopia, these data are consistent with the possibility of a locus on chromosome 18p.
着者Lam DSC, Tam POS, Fan DSP, Baum L, Leung YF, Pang CP
期刊名称Ophthalmologica
出版年份2003
月份3
日期1
卷号217
期次2
出版社KARGER
页次115 - 118
国际标準期刊号00http://aims.cuhk.edu.hk/converis/portal/Publication/30-3755
电子国际标準期刊号1423-0267
语言英式英语
关键词chromosome 18; myopia gene; myopia, high
Web of Science 学科类别Ophthalmology; OPHTHALMOLOGY
