Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 王华婷教授 (李嘉诚健康科学研究所) |
| 孙昊教授 (化学病理学系) |
| 刘达燊博士 (妇产科学系) |
| 江培勇教授 (化学病理学系) |
| 周良博士 (妇产科学系) |
| 孙坤教授 (化学病理学系) |
| 杨一华博士 (妇产科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1158/0008-5472.CAN-14-0427 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/30WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/35Scopus source URL
其它资讯
摘要The Protocadherin 10 (PCDH10) is inactivated often by promoter hypermethylation in various human tumors, but its possible functional role as a tumor suppressor gene is not established. In this study, we identify PCDH10 as a novel Wnt pathway regulatory element in endometrioid endometrial carcinoma (EEC). PCDH10 was downregulated in EEC tumor cells by aberrant methylation of its promoter. Restoring PCDH10 levels suppressed cell growth and triggered apoptosis in EEC cells and tumor xenografts. Gene expression profiling revealed as part of the transcriptomic changes induced by PCDH10 a reduction in levels of MALAT1, a long noncoding RNA, that mediated tumor suppression functions of PCDH10 in EEC cells. We found that MALAT1 transcription was regulated by Wnt/β-catenin signaling via TCF promoter binding and PCDH10 decreased MALAT1 by modulating this pathway. Clinically, MALAT1 expression was associated with multiple parameters in patients with EEC. Taken together, our findings establish a novel PCDH10-Wnt/β-catenin-MALAT1 regulatory axis that contributes to EEC development.
着者Zhao Y., Yang Y., Trovik J., Sun K., Zhou L., Jiang P., Lau T.-S., Hoivik E.A., Salvesen H.B., Sun H., Wang H.
期刊名称Cancer Research
出版年份2014
月份8
日期1
卷号74
期次18
出版社American Association for Cancer Research
出版地United States
页次5103 - 5117
国际标準期刊号0008-5472
电子国际标準期刊号1538-7445
语言英式英语
