Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄志超教授 (妇产科学系) |
| 冯国培教授 (生物医学学院) |
| 何宗信教授 (化学病理学系) |
| 朱静欣小姐 (妇产科学系) |
全文
| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/7$@○○ |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
其它资讯
摘要Melamine can be transferred to fetus in utero through placenta and to infant ex utero by breast feeding. In this study, we characterized the pharmacokinetics of melamine in prenatal and postnatal organs in rats. Single bolus of melamine was administered to pregnant rats at different gestational stages and to infants at different postnatal stages. Distribution of melamine in maternal serum was about 30% higher in late pregnancy than that in early pregnancy; and it was 2 folds higher in postnatal serum in early infants in young adulthood. Distribution of melamine in all postnatal organs was higher than that in prenatal organs. Postnatal kidneys in early infants had the highest maximum concentration and the lowest clearance of melamine than the other postnatal organs. It may relate to the high vulnerability to the toxicity of melamine in this population. (C) 2012 Elsevier Inc. All rights reserved.
着者Chu CY, Chu KO, Ho CS, Kwok SS, Chan HM, Fung KP, Wang CC
期刊名称REPRODUCTIVE TOXICOLOGY
出版年份2013
月份1
日期1
卷号35
出版社PERGAMON-ELSEVIER SCIENCE LTD
页次40 - 4http://aims.cuhk.edu.hk/converis/portal/Publication/7
国际标準期刊号0890-6238
语言英式英语
关键词Distribution; Infants; Melamine; Pharmacokinetics; Pregnancy
Web of Science 学科类别Reproductive Biology; REPRODUCTIVE BIOLOGY; Toxicology; TOXICOLOGY
