Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 孙昊教授 (化学病理学系) |
| 王华婷教授 (李嘉诚健康科学研究所) |
| 苏小茜女士 (化学病理学系) |
| 郭梦彪先生 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/database/bat007 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
其它资讯
摘要Yin Yang 1 (YY1), a ubiquitously expressed transcription factor, plays a critical role in regulating cell development, differentiation, cellular proliferation and tumorigenesis. Previous studies identified many YY1-regulated target genes in both human and mouse. Emerging global mapping by Chromatin ImmnoPrecipitation (ChIP)-based high-throughput experiments indicate that YY1 binds to a vast number of loci genome-wide. However, the information is widely scattered in many disparate poorly cross-indexed literatures; a large portion was only published recently by the ENCODE consortium with limited annotation. A centralized database, which annotates and organizes YY1-binding loci and target motifs in a systematic way with easy access, will be valuable resources for the research community. We therefore implemented a web-based YY1 Target loci Database (YY1TargetDB). This database contains YY1-binding loci (binding peaks) from ChIP-seq and ChIP-on-chip experiments, computationally predicated YY1 and cofactor motifs within each locus. It also collects the experimentally verified YY1-binding motifs from individual researchers. The current version of YY1TargetDB contains 92 http://aims.cuhk.edu.hk/converis/portal/Publication/314 binding loci identified by ChIP-based experiments; 157 200 YY1-binding motifs in which 42 are experimentally verified and 157 158 are computationally predicted; and 1http://aims.cuhk.edu.hk/converis/portal/Publication/30 759 binding motifs for 47 cofactors.
着者Guo AM, Sun K, Su XX, Wang HT, Sun H
期刊名称DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
出版年份201http://aims.cuhk.edu.hk/converis/portal/Publication/3
月份2
日期14
出版社Oxford University Press (OUP): Policy C - Option A / Oxford University Press
国际标準期刊号1758-046http://aims.cuhk.edu.hk/converis/portal/Publication/3
语言英式英语
Web of Science 学科类别Mathematical & Computational Biology; MATHEMATICAL & COMPUTATIONAL BIOLOGY
