Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 罗国炜教授 (病理解剖及细胞学系) |
| 伦慧敏博士 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.5732/cjc.014.10081 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/12WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/11Scopus source URL
其它资讯
摘要Although the Epstein-Barr virus (EBV) has spread to all populations in the world, EBV-associated nasopharyngeal carcinoma (NPC) is prevalent only in South China and Southeast Asia. The role of EBV in the malignant transformation of nasopharyngeal epithelium is the main focus of current researches. Radiotherapy and chemoradiotherapy have been successful in treating early stage NPC, but the recurrence rates remain high. Unfortunately, local relapse and metastasis are commonly unresponsive to conventional treatments. These recurrent and metastatic lesions are believed to arise from residual or surviving cells that have the properties of cancer stem cells. These cancer stem-like cells (CSCs) have the ability to selfrenew, differentiate, and sustain propagation. They are also chemo-resistant and can form spheres in anchorage-independent environments. This review summarizes recent researches on the CSCs in EBVassociated NPC, including the findings regarding cell surface markers, stem cell-related transcription factors, and various signaling pathways. In particular, the review focuses on the roles of EBV latent genes [latent membrane protein 1 (LMP1) and latent membrane protein 2A (LMP2A)], cellular microRNAs, and adenosine triphosphate (ATP)-binding cassette chemodrug transporters in contributing to the properties of CSCs, including the epithelial-mesenchymal transition, stem-like transition, and chemo-resistance. Novel therapeutics that enhance the efficacy of radiotherapy and chemoradiotherapy and inhibitors that suppress the properties of CSCs are also discussed.
着者Lun S.W.-M., Cheung S.-T., Lo K.-W.
期刊名称Chinese Journal of Cancer
出版年份2014
月份1
日期1
卷号33
期次http://aims.cuhk.edu.hk/converis/portal/Publication/11
出版社Landes Bioscience
出版地United States
页次529 - 538
国际标準期刊号1000-467X
电子国际标準期刊号1944-446X
语言英式英语
关键词Cancer stem-like cells, Epstein-Barr virus, Microrna, Nasopharyngeal carcinoma, Signalling pathway
