Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
| 梁廷勋教授 (儿科学系) |
| 陈重娥教授 (内科及药物治疗学系) |
| 林伟基教授 (化学病理学系) |
| 黄永坚教授 (儿科学系) |
| 李颂仪女士 (儿科学系) |
| 邓亮生教授 (化学病理学系) |
| 江碧珊教授 (内科及药物治疗学系) |
| 韩锦伦教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/ppul.21242 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Positional cloning and candidate gene studies in different Caucasian populations identified the gene encoding plant homeodomain zinc finger protein 11 (PHF11) to be associated with asthma and eczema. Microarray analysis also confirmed increased PHF11 expression in type 1 T-helper lymphocytes. However, such disease associations are unclear in Asian subjects. This case control genetic association study investigated the relationship between asthma and eczema phenotypes and tagging single-nucleotide polymorphisms (SNPs) of PHF11 in Hong Kong Chinese children. Three hundred and nineteen asthmatic children and 236 children with eczema were recruited from hospital clinics and 445 children without any history of allergic disease were recruited as controls from local schools and hospitals. Atopy was defined by the presence of allergen-specific IgE in plasma or positive skin prick tests with wheal >= 3 mm larger than negative control. Lung function of asthmatics was evaluated by pre-bronchodilator spirometry. Ten PHF11 SNPs were genotyped by multiplex SNaPshot (TM) assay. Genotyping call rates were 1http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0% for all SNPs, which also followed Hardy-Weinberg equilibrium. These SNPs were tightly linked in one haplotype block (D' >= http://aims.cuhk.edu.hk/converis/portal/Publication/0.95 for nearly all SNP pairs). Physician-diagnosed asthma was weakly associated with PHF11 +2http://aims.cuhk.edu.hk/converis/portal/Publication/086http://aims.cuhk.edu.hk/converis/portal/Publication/0 and +22818 (P=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/032 for both). Atopy was also associated with PHF11 +22398 (P=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/029). However, none of the PHF11 SNPs was associated with eczema diagnosis and plasma total IgE and spirometric parameters in our patients. Our findings do not support PHF11 to be a major candidate gene for asthma, eczema and aeroallergen sensitization in Chinese children. Pediatr Pulmonol. 2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0; 45:89http://aims.cuhk.edu.hk/converis/portal/Publication/0-897. (C) 2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0 Wiley-Liss, Inc.
着者Sy HY, Chan IHS, Hon EKL, Kong APS, Tang NLS, Li CY, Wong GWK, Waye MMY, Lam CWK, Chan JCN, Leung TF
期刊名称PEDIATRIC PULMONOLOGY
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
月份9
日期1
卷号45
期次9
出版社WILEY-LISS
页次89http://aims.cuhk.edu.hk/converis/portal/Publication/0 - 897
国际标準期刊号8755-6863
电子国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/099-http://aims.cuhk.edu.hk/converis/portal/Publication/0496
语言英式英语
关键词asthma; Chinese; eczema; plant homeodomain finger protein 11; single-nucleotide polymorphism
Web of Science 学科类别Pediatrics; PEDIATRICS; Respiratory System; RESPIRATORY SYSTEM
