Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈永鸿教授 (病理解剖及细胞学系) |
| 吕智伟教授 (病理解剖及细胞学系) |
| 王思朗博士 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/modpathol.2009.187 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要A significant proportion of ductal carcinomas in situ (DCISs) of the breast diagnosed on core biopsies had invasion upon excision. An assessment of various invasion predictors in the biopsies yielded conflicting results. A cohort of 157 cases with needle core biopsy diagnosed with DCISs (including 10http://aims.cuhk.edu.hk/converis/portal/Publication/9 histologically proven DCISs, and 48 cases with invasion upon excision) were evaluated for the numbers of positive and total cores, the percentage of positivity, lobular cancerization, tumor nuclear grade, necrosis, calcification, predominate histological pattern, lymphocytic infiltrate and excisional tumor size. The mean positive core percentage and excisional tumor size were 76% and 2.8 cm for invasive and 66% and 1.http://aims.cuhk.edu.hk/converis/portal/Publication/9 cm for noninvasive groups. In the biopsy of the invasive group, cancerization of lobules was present in 52%, and nuclear grades 1, 2 and 3 were present in 31, 31 and 38%, respectively. Large comedo and small noncomedo necroses were present in 48 and 10%, whereas large and small calcifications were present in 16 and 21%. Solid, cribriform and papillary patterns were observed in 88, 38 and 21%, respectively. Moderate to marked lymphoid infiltrate was present in 31%. In the biopsy of the noninvasive group, cancerization of lobules was present in 6http://aims.cuhk.edu.hk/converis/portal/Publication/9%, and the nuclear grades 1, 2 and 3 were present in 23, 48 and 2http://aims.cuhk.edu.hk/converis/portal/Publication/9%, respectively. Large comedo and small noncomedo necroses were present in 35 and 11%, whereas large and small calcifications were present in 33 and 23%. Solid, cribriform and papillary patterns were observed in 85, 3http://aims.cuhk.edu.hk/converis/portal/Publication/9 and http://aims.cuhk.edu.hk/converis/portal/Publication/9%, respectively. Moderate to marked lymphoid infiltrate was present in 36%. Comparing these groups, a higher positive core percentage, papillary pattern and less cancerization of lobules in the cores and larger excisional tumor size were associated with a higher chance of invasion. Calcification, necrosis and nuclear grade were not significant invasion predictors. Modern Pathology (2010) 23, 737-742; doi: 10.1038/modpathol.200http://aims.cuhk.edu.hk/converis/portal/Publication/9.187; published online 15 January 2010
着者Go EML, Chan SK, Vong JSL, Lui PCW, Chan AWH, Ma TKF, Ang MA, Law BKB, Tan PH, Tse GM
期刊名称MODERN PATHOLOGY
详细描述Epub 2010 Jan 15.
出版年份2010
月份5
日期1
卷号23
期次5
出版社Nature Publishing Group: Open Access Hybrid Model Option B
页次737 - 742
国际标準期刊号08http://aims.cuhk.edu.hk/converis/portal/Publication/93-3http://aims.cuhk.edu.hk/converis/portal/Publication/952
电子国际标準期刊号1530-0285
语言英式英语
关键词breast; core biopsy; ductal carcinoma in situ
Web of Science 学科类别Pathology; PATHOLOGY
