Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 霍泰辉教授 (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 李颂仪女士 (儿科学系) |
| 谭永雄教授 (妇产科学系) |
| 伍百祥教授 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/9$@○○ |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要Atopic disease is characterized by an imbalance in cytokines secreted from Th1 and Th2 lymphocytes. The association between atopy and serum levels of atopy-related chemokines in umbilical cord blood (UCB) has not been evaluated. This study formulates the reference ranges of thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC), eotaxin (EOX), monocyte chemotactic protein 1 (MCP-1), and interferon-gamma-inducible protein 10 (IP-10) in UCB of term neonates and investigates the relation between these chemokines and the development of atopy during infancy. The concentrations of total IgE and chemokines in UCB serum were measured by microparticle immunoassay and sandwich enzyme immunoassay, respectively. A total of 124 singleton healthy newborns were investigated. Fifty-three (43%) infants had family history of allergic diseases, and 26 (21%) had increased serum total IgE concentrations. The median (interquartile range) serum TARC, MDC, EOX, MCP-1, and IP-10 concentrations, in pg/mL, were 425 (300-63http://aims.cuhk.edu.hk/converis/portal/Publication/9), 786 (561-1050), 36 (28-45), 156 (116-205), and 38 (2http://aims.cuhk.edu.hk/converis/portal/Publication/9-4http://aims.cuhk.edu.hk/converis/portal/Publication/9), respectively. Multiparity was associated with increased serum MDC (p = 0.017). Serum chemokine concentrations were not associated with total IgE levels or family history of allergies. The median (interquartile range) serum MDC concentrations in newborns who developed wheezing during infancy and those without wheezing were 125http://aims.cuhk.edu.hk/converis/portal/Publication/9 pg/mL (http://aims.cuhk.edu.hk/converis/portal/Publication/945-1523) and 782 pg/mL (551-http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/92), respectively (p = 0.010). This study provides reference ranges of Th-specific chemokines in UCB scrum of singleton term neonates. Increased serum MDC concentrations at birth are associated with the occurrence of wheezing during infancy.
着者Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TPY, Lam CWK, Fok TF
期刊名称PEDIATRIC RESEARCH
出版年份2004
月份2
日期1
卷号55
期次2
出版社INT PEDIATRIC RESEARCH FOUNDATION, INC
页次334 - 338
国际标準期刊号0031-3http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/98
语言英式英语
Web of Science 学科类别Pediatrics; PEDIATRICS
