Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 叶伟基博士 (化学病理学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 锺尚志教授 (外科学系) |
| 许树昌教授 (内科及药物治疗学系) |
| 李礼舜教授 (内科及药物治疗学系) |
| 叶伟基博士 (化学病理学系) |
| 林伟基教授 (化学病理学系) |
| 黄振国教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1365-2249.2004.02415.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/183WOS source URL
其它资讯
摘要Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. We investigated changes in plasma T helper (Th) cell cytokines, inflammatory cytokines and chemokines in 20 patients diagnosed with SARS. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine interferon (IFN)-gamma, inflammatory cytokines interleukin (IL)-1, IL-6 and IL-12 for at least 2 weeks after disease onset, but there was no significant elevation of inflammatory cytokine tumour necrosis factor (TNF)-alpha, anti-inflammatory cytokine IL-10, Th1 cytokine IL-2 and Th2 cytokine IL-4. The chemokine profile demonstrated significant elevation of neutrophil chemokine IL-8, monocyte chemoattractant protein-1 (MCP-1), and Th1 chemokine IFN-gamma-inducible protein-10 (IP-10). Corticosteroid reduced significantly IL-8, MCP-1 and IP-10 concentrations from 5 to 8 days after treatment (all P < 0.001). Together, the elevation of Th1 cytokine IFN-gamma, inflammatory cytokines IL-1, IL-6 and IL-12 and chemokines IL-8, MCP-1 and IP-10 confirmed the activation of Th1 cell-mediated immunity and hyperinnate inflammatory response in SARS through the accumulation of monocytes/macrophages and neutrophils.
着者Wong CK, Lam CWK, Wu AKL, Ip WK, Lee NLS, Chan IHS, Lit LCW, Hui DSC, Chan MHM, Chung SSC, Sung JJY
期刊名称Clinical and Experimental Immunology
出版年份2004
月份4
日期1
卷号136
期次1
出版社BLACKWELL PUBLISHING LTD
页次95 - 103
国际标準期刊号0009-9104
电子国际标準期刊号1365-2249
语言英式英语
关键词chemokines; cytokines; inflammation; severe acute respiratory syndrome (SARS)
Web of Science 学科类别Immunology; IMMUNOLOGY
