Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 潘力行教授 (化学病理学系) |
| 韩英士教授 (妇产科学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/74WOS source URL
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摘要A tartrate-resistant acid phosphatase (TRACP) was purified from cord plasma by use of cation-exchange chromatography (carboxymethyl Sepharose), gel-filtration chromatography (Sephacryl S-200), and preparative isoelectric focusing. After raising polyclonal antibodies to the purified TRACP in rabbit, we used the antiserum to develop an ELISA. The antiserum cross-reacted with an extract of bone, but not with extracts of spleen, erythrocytes, platelets, or osteoblasts or with prostatic acid phosphatase. With this ELISA we determined the concentration of serum TRACP in healthy men to be 197 (61-301) mu g/L (median and range). Serum TRACP concentrations were significantly higher in children and postmenopausal women and in patients with chronic renal failure, hyperparathyroidism, or hyperthyroidism. Estrogen replacement therapy of postmenopausal women for 3-6.5 months decreased their serum TRACP concentration by 70%.
着者CHEUNG CK, PANESAR NS, HAINES C, MASAREI J, SWAMINATHAN R
期刊名称Clinical Chemistry
出版年份1995
月份5
日期1
卷号41
期次5
出版社AMER ASSOC CLINICAL CHEMISTRY
页次679 - 686
国际标準期刊号0009-9147
电子国际标準期刊号1530-8561
语言英式英语
关键词BONE RESORPTION; ENZYME-LINKED IMMUNOASSAY; MENOPAUSAL STATUS; OSTEOCLASTS
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
