Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 崔耀隆教授 (化学病理学系) |
| 雷兆辉教授 (赛马会公共卫生及基层医疗学院) |
| 陈学深教授 |
| 赖奇伟教授 |
| 李锦滔教授 |
| 黎嘉能教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000188390 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
其它资讯
摘要There is accumulating evidence that leukocyte-endothelial adhesion molecules are important in inflammatory injury in being involved in the primary step of entrapment and migration of leukocytes to the site of inflammation. We have used an antigen capture ELISA to measure the levels of circulating intercellular adhesion molecule-1 (cVCAM-1), vascular cell adhesion molecule-1 (cVCAM-1) and E selectin (cE selectin) in the peripheral blood of 33 patients with IgA nephropathy (IgAN) during clinical quiescence and 24 healthy controls. The serum levels of cICAM-1 and E selectin in IgA-nephritic patients were not different from that of healthy controls but the cVCAM-1 level was significantly elevated in IgAN despite a lack of clinical activity (p=0.008). The differential rise of circulating leukocyte-endothelial adhesion molecules in IgAN probably reflects the origins and nature of these molecules as well as the specific immunological profile of IgAN. There was no correlation between the levels of these three circulating adhesion molecules. When the patients with IgA nephropathy were stratified according to the severity of their glomerular and interstitial lesions, there was an apparent increase in cE selectin and cVCAM-1 associated with increased histopathologic grading. The changes in endothelial adhesion molecules during clinical exacerbation were studied in 10 patients. Coinciding with synpharyngitic macrohematuria, there was a significant rise of cVCAM-1 and cE selectin (p=0.046 and p=0.016, respectively) but no similar rise was observed in cICAM-1. Though probably of limited diagnostic significance, our findings tend to support the role of T lymphocyte in the immunopathogenesis in IgAN and also indirectly reflect the active interaction between neutrophils/lymphocytes and vascular endothelial cells during the clinical exacerbation in IgAN.
着者LAI KN, WONG KC, LI PKT, LAI CKW, CHAN CHS, LUI SF, CHUI YL, HASKARD DO
期刊名称Nephron
出版年份1994
月份11
日期1
卷号68
期次3
出版社KARGER
页次294 - 300
国际标準期刊号0028-2766
语言英式英语
关键词DISEASE ACTIVITY; E SELECTIN; IGA NEPHROPATHY; INTERCELLULAR ADHESION MOLECULE-1; VASCULAR CELL ADHESION MOLECULE-1
Web of Science 学科类别Urology & Nephrology
