THE CONTRIBUTION OF STEROIDS TO DIGOXIN-LIKE IMMUNOREACTIVITY IN CORD BLOOD
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香港中文大学研究人员 ( 现职)

潘力行教授 (化学病理学系)

何宗信教授 (化学病理学系)

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摘要Samples of cord serum from 29 healthy neonates were analysed for digoxin-like immunoreactive substance (DLIS), cortisol, 1http://aims.cuhk.edu.hk/converis/portal/Publication/7-beta-oestradiol, progesterone, dehydroepiandrosterone-sulphate (DHEAS), 1http://aims.cuhk.edu.hk/converis/portal/Publication/7-alpha-hydroxyprogesterone (1http://aims.cuhk.edu.hk/converis/portal/Publication/7OHP), androstenedione, oestriol and ouabain-like activity (OLA; by inhibition of Na+,K+ATPase activity). The mean serum concentration of DLIS was 0.91 (SD = 0.19) nmol/L and the mean OLA was 26.1 (SD = 11.5) nmol/L. There was no correlation between DLIS and OLA. DLIS correlated significantly with oestriol (r = 0.521), progesterone (r = 0.534) and 1http://aims.cuhk.edu.hk/converis/portal/Publication/7OHP (r = 0.43). Stepwise multiple regression analysis showed that 1http://aims.cuhk.edu.hk/converis/portal/Publication/7-beta-oestradiol, progesterone and androstenedione contributed to DL IS and the intercept was 0.64 (SD = 0.12http://aims.cuhk.edu.hk/converis/portal/Publication/7). The concentrations of steroids (Ihttp://aims.cuhk.edu.hk/converis/portal/Publication/7-beta-oestradiol, progesterone, androstenedione) required to displace digoxin by 50% in the digoxin immunoassay and inhibit Na+,K+ATPase in the OLA assay were 10(3)-10(4)-fold higher than those found in cord serum. We conclude that the contribution of these steroids to DLIS is small and that DLIS and OLA measure different compounds.

着者WONG SY, HO CS, PANESAR NS, SWAMINATHAN R
期刊名称Annals of Clinical Biochemistry
出版年份1992
月份5
日期1
卷号29
出版社ROYAL SOC MEDICINE SERVICES LTD
页次33http://aims.cuhk.edu.hk/converis/portal/Publication/7 - 342
国际标準期刊号0004-5632
电子国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/758-1001
语言英式英语

关键词1http://aims.cuhk.edu.hk/converis/portal/Publication/7-HYDROXYPROGESTERONE PROGESTERONE; DIGOXIN; NA+,K+ATPASE INHIBITOR
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY