Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
| 黎嘉能教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/BF02550423 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/2Scopus source URL
其它资讯
摘要This work was undertaken to examine the effect of cyclosporine A (CyA) on the serum concentration of circulating immune complexes in http://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/2 patients with IgA nephropathy during an infection-free period. They were randomly divided into http://aims.cuhk.edu.hk/converis/portal/Publication/2 groups: 11 patients received oral cyclosporine A (5 mg/kg/day) for 1http://aims.cuhk.edu.hk/converis/portal/Publication/2 weeks and 11 patients received placebo (0.05 ml/kg/day). A significant reduction of proteinuria was observed in patients on CyA therapy but not in those receiving placebo. IgG-circulating immune complexes (CIC) were determined by solid phase Clq enzyme immunoassay (Clq EIA) and radial immunodiffusion (RID) and IgA-CIC were determined by solid phase anti-C3 enzyme immunoassay (anti-C3 EIA) and radial immunodiffusion. There was no change in IgA-CIC measured by RID and anti-C3 EIA after 1http://aims.cuhk.edu.hk/converis/portal/Publication/2 weeks of CyA therapy. Similarly, changes in IgG-CIC were not demonstrated with CyA therapy. No apparent decrease in IgG-CIC or IgA-CIC was observed with placebo treatment. Our study suggests that immunomodulation by CyA therapy does not affect the IgA-CIC and IgG-CIC levels in patients with IgA nephropathy. ? 1991 Akadémiai Kiadóa.
着者Lai K.N., Lam C.W.K., Cheng I.K.P., Tam J.S.L., Lai F.M.
期刊名称International Urology and Nephrology
出版年份1991
月份5
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/23
期次3
出版社Kluwer Academic Publishers
出版地Netherlands
页次http://aims.cuhk.edu.hk/converis/portal/Publication/265 - http://aims.cuhk.edu.hk/converis/portal/Publication/274
国际标準期刊号0301-16http://aims.cuhk.edu.hk/converis/portal/Publication/23
语言英式英语
