Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黎嘉能教授 (内科及药物治疗学系) |
| 李国铭教授 |
| 梁慧仪教授 |
| 林伟基教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/0009-9120(91)80021-T |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
其它资讯
摘要We have determined the individual kappa (kappa)/ lambda (lambda) ratios of serum IgG, IgA, and IgM in normal subjects and patients with rheumatoid arthritis, systemic lupus erythematosus, hepatic cirrhosis and IgA nephropathy - 40 in each group. Serum samples were first screened by agarose electrophoresis to exclude paraproteinaemia. Concentrations of IgG, IgA, and IgM were determined by enzyme-linked immunosorbent assay (ELISA). The kappa and lambda-chain concentrations of each immunoglobulin class were assayed by an ELISA method first developed by us for the determination of kappa/lambda ratios. Our results showed that kappa/lambda ratios of serum IgA and IgM were significantly different from that of IgG in normal subjects and the 4 groups of patients studied (p < 0.01). The kappa/lambda ratios of individual immunoglobulins in patients with rheumatoid arthritis, systemic lupus erythematosus and liver cirrhosis were similar to those of normal subjects. However, patients with IgA nephropathy displayed a distinctly lower IgA kappa/lambda ratio, suggesting a unique antibody response in the immunopathogenesis of this disease.
着者LAM CWK, CHUI SH, LEUNG NWY, LI EKM, LAI KN
期刊名称CLINICAL BIOCHEMISTRY
出版年份1991
月份6
日期1
卷号24
期次3
出版社PERGAMON-ELSEVIER SCIENCE LTD
页次283 - 287
国际标準期刊号0009-9120
电子国际标準期刊号1873-2933
语言英式英语
关键词ELISA; IGA NEPHROPATHY; IMMUNE-COMPLEX DISEASE; LIGHT CHAIN RATIOS; SERUM IMMUNOGLOBULINS
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
