Targeting of non-lg sequences in place of the V segment by somatic hyper mutation
Publication in refereed journal


香港中文大学研究人员 ( 现职)

崔耀隆教授 (化学病理学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1038/376225a0

引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/196Scopus source URL

其它资讯

摘要Affinity maturation of antibodies is characterized by localized hypermutation of the DNA around the V segment. Here we show, using mice containing single or multiple transgene constructs, that an immunoglobulin VK segment can be replaced by human β-globin or prokaryotic neo or gpt genes without affecting the rate of hypermutation; the V gene itself is not necessary for recruiting hypermutation. The ability to target hypermutation to heterologous genes in vivo could find more general applications in biology. ? 1995 Nature Publishing Groups. All Rights Reserved.

着者Yelamos G., Klix N., Goyenechea B., Lozano F., Chui Y.L., Fernandez A.G., Pannell R., Neuberger M.S., Milstein C.
期刊名称Nature
出版年份1995
月份7
日期20
卷号376
期次6537
出版社Nature Publishing Group
出版地United Kingdom
页次225 - 229
国际标準期刊号0028-0836
语言英式英语