Targeting of non-lg sequences in place of the V segment by somatic hypermutation
Publication in refereed journal


香港中文大学研究人员 ( 现职)

崔耀隆教授 (化学病理学系)

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摘要Affinity maturation of antibodies is characterized by localized hypermutation of the DNA around the V segment. Here we show, using mice containing single or multiple transgene constructs, that an immunoglobulin Vκ segment can be replaced by human β-globin or prokaryotic neo or gpt genes without affecting the rate of hypermutation; the V gene itself is not necessary for recruiting hypermutation. The ability to target hypermutation to heterologous genes in vivo could find more general applications in biology.

着者Yelamos J., Klix N., Goyenechea B., Lozano F., Chui Y.L., Gonzalez Fernandez A., Pannell R., Neuberger M.S., Milstein C.
期刊名称Nature
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/1995
月份7
日期20
卷号376
期次6537
出版社Nature Publishing Group
出版地United Kingdom
国际标準期刊号0028-0836
语言英式英语