基本信息科学研究教学研究论文著作
基本信息
添加基本信息


工作经历

标题国内工作经历

职位,职务,职称副教授（准聘）

工作地点,工作单位哈尔滨工业大学生命学院

起讫时间2017.04-至今



标题海外工作经历

职位,职务,职称博士后

工作地点,工作单位美国纽约西奈山医学院

起讫时间2012.12-2015.12



标题国内工作经历

职位,职务,职称副教授

工作地点,工作单位哈尔滨医科大学生物信息科学与技术学院

起讫时间2012.09-2017.03



标题国内工作经历

职位,职务,职称讲师

工作地点,工作单位哈尔滨医科大学生物信息科学与技术学院

起讫时间2009.07-2012.07



教育经历

标题博士学习经历

起讫时间2008/9 - 2011/6

所学专业生物物理学

学习机构哈尔滨医科大学

学历2008/9 - 2011/6



标题硕士学习经历

起讫时间2004/9 - 2006/7

所学专业计算机科学与技术

学习机构哈尔滨工业大学

学历硕士



标题本科学习经历

起讫时间2000/9 - 2004/7

所学专业软件工程

学习机构哈尔滨工业大学

学历本科


宏基因组学和基因编辑
自2005年起长期从事复杂疾病相关生物分子标志物的生物信息学和系统生物学的研究。2012年12月至2015年12月在美国纽约西奈山医学院生物信息学研究中心，从事计算生物学和基因组学的研究工作，在生物分子网络分析、癌症相关分子标志物挖掘、高通量测序组学数据分析等方面都积累了丰富的研究经验，相关成果发表在《Molecular Cell》、《Briefings in Bioinformatics》、《Cancer Research》、《Cell stem Cell》等杂志上。回国后加入哈工大生命学院，现在的主要研究方向是肠道微生物与疾病的关联研究，主要基于宏基因组数据来进行CRISPR相关的研究工作和微生物群落间的动态相互作用等研究工作。


科研项目

项目名称基于层次化系统模型研究复杂疾病表型的遗传调控机制

项目来源国家自然科学基金青年项目

开始时间2013.01

结束时间2015.12

项目经费200000,000

担任角色负责

项目类别纵向项目

项目状态完成



项目名称基于噬菌体-细菌-宿主互作网络分析研究肠道菌群和结直肠癌的关联机 制及噬菌体干预治疗策

项目来源国家自然基金 面上项目

开始时间2019.01

结束时间2021.12

项目经费60万

担任角色负责

项目类别纵向项目

项目状态进行中


讲授课程
生物数学应用与生物统计

模式识别与机器学习

招生信息
招收有生物信息学、计算机专业背景的硕士研究生


期刊论文
Dong, L., Guan, X., Li, N., Zhang, F., Zhu, Y., Ren, K., Yu, L., Zhou, F., Han, Z., Gao, N. et al. (2019) An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology.

Zhang, F.(#)(*) et.al, "CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions." Communications Biology 1(1): 180.

Zhu, Y., Zhang, F. & Huang, Z. Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins. BMC Biol 16, 32, doi:10.1186/s12915-018-0504-9 (2018).

Cheung, Ka Lung(#);Zhang, Fan(#) et.al Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation, MOLECULAR CELL, 2017.3.16, 65(6): 1068~+ （IF：14.714）

Aguilo, Francesca(*); Zhang, Fan; et.al, Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming, CELL STEM CELL, 2015.12.3, 17(6): 689~704 （IF：23.393）

Guo, Haiyang(#); Ahmed, Musaddeque(#); Zhang, Fan et.al, Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer, NATURE GENETICS, 2016.10, 48(10): 1142~1150 （IF：27.958）

Rengasamy, Madhumitha; Zhang, Fan et.al, The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer, NUCLEIC ACIDS RESEARCH, 2017.8.21, 45(19): 11106~11120 （IF：10.162）

Di Cecilia, Serena(#); Zhang, Fan et.al, RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells., Cancer Res, 2016.10.1, 76(19): 5615~5627 （IF：9.122）

Zhang, Fan(#)(*) et.al, A network medicine approach to build a comprehensive atlas for the prognosis of human cancer, BRIEFINGS IN BIOINFORMATICS, 2016.11, 17(6): 1044~1059 （IF：6.302）

Zhang, Fan(#) et. al Allele-Specific Behavior of Molecular Networks: Understanding Small-Molecule Drug Response in Yeast, PLos One, 2013.1.4, 8(1) （IF：2.8059）

Zhang, Fan(#) et.al, Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data, Oncotarget, 2016.11.1, 7(44): 71620~71634

Wu, Chao(#); Zhang, Fan(#) et.al Composite functional module inference: detecting cooperation between transcriptional regulation and protein interaction by mantel test, BMC Systems Biology, 2010.6.10, 4:1~11 （IF：2.303）

Haines, Jeffery D.(#); Vidaurre, Oscar G.(#); Zhang, Fan(#); et.al, Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors, MULTIPLE SCLEROSIS JOURNAL, 2015.11, 21(13): 1655~1669 （IF：4.84）

Chen DiJun(#); Zhang Fan(#) et.al , A web-based platform for rice microarray annotation and data analysis, Science China Life Sciences, 2010.12, 53(12): 1467~1473 （IF：2.781）

Zhang, Fan(#); et.al, The enhancer landscape involves a core noncoding RNA protein interaction network for C-MYC expression, AACR Special Conference on Noncoding RNAs and Cancer - Mechanisms to Medicines, Boston, MA, 2015.12.4-2015.12.7 (会议论文)

Zhang, Fan(#); et.al, A heuristic approach for target SNP mining based on genome-wide IBD profile, 3rd International Conference on Natural Computation (ICNC 2007), Haikou, PEOPLES R CHINA, 2007.8.24-2007.8.27 (会议论文)

Liu, Jia; Magri, Laura; Zhang, Fan et.al, Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation, JOURNAL OF NEUROSCIENCE, 2015.1.7, 35(1): 352~365 （IF：5.988）

Moyon, Sarah; Huynh, Jimmy L.; Dutta, Dipankar; Zhang, Fan et.al, Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage, CELL REPORTS, 2016.4.26, 15(4): 748~760 （IF：8.282）

Li, Chunquan; Li, Xia; Miao, Yingbo; Wang, Qianghu; Jiang, Wei; Xu, Chun; Li, Jing; Han, Junwei; Zhang, Fan et.al, SubpathwayMiner: a software package for flexible identification of pathways, Nucleic Acids Research, 2009.10, 37(19) （IF：10.162）

Sancho, Ana; Li, SiDe; Paul, Thankam; Zhang, Fan et.al, CHD6 regulates the topological arrangement of the CFTR locus, HUMAN MOLECULAR GENETICS, 2015.5.15, 24(10): 2724~2732 （IF：5.34）

Shaojun Zhang(#); Fang Wang(#); Hongzhi Wang; Fan Zhang; Bin Xu; Xia Li(*); Yadong Wang(*), Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals, Gene, 2014.1.1, 533(1): 366~373 （IF：2.415）

Han, Junwei; Liu, Siyao; Sun, Zeguo; Zhang, Yunpeng; Zhang, Fan et.al, LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method, SCIENTIFIC REPORTS, 2017.4.20, 7 （IF：4.259）

Liu, Wei; Li, Chunquan; Xu, Yanjun; Yang, Haixiu; Yao, Qianlan; Han, Junwei; Shang, Desi; Zhang, Chunlong; Su, Fei; Li, Xiaoxi; Xiao, Yun; Zhang, Fan; Dai, Meng; Li, Xia, Topologically inferring risk-active pathways toward precise cancer classification by directed random walk, Bioinformatics, 2013.9.1, 29(17): 2169~2177 （IF：7.307）

Li, Jiang; Gong, Binsheng; Chen, Xi; Liu, Tao; Wu, Chao; Zhang, Fan; Li, Chunquan; Li, Xiang; Rao, Shaoqi(*); Li, Xia, DOSim: An R package for similarity between diseases based on Disease Ontology, BMC Bioinformatics, 2011.6.29, 12 （IF：2.448）

Cheung, Kalung(#); Lu, Geming(#); Sharma, Rajal; Vincek, Adam; Zhang, Ruihua; Plotnikov, Alexander N.; Zhang, Fan; et.al, BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017.3.14, 114(11): 2952~2957 （IF：9.661）

Aguilo, Francesca(#); Li, SiDe(#); Balasubramaniyan, Natarajan(#); Sancho, Ana; Benko, Sabina; Zhang, Fan; et.al, Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1 alpha, CELL REPORTS, 2016.1.26, 14(3): 479~492 (IF: 8.282 )

Vidaurre, Oscar G.; Haines, Jeffery D.; Sand, Ilana Katz; Adula, Kadidia P.; Huynh, Jimmy L.; McGraw, Corey A.; Zhang, Fan et.al, Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics, BRAIN, 2014.8, 137: 2271~2286 （IF：10.292）

Sun, Jie(#); Gao, Bo(#); Zhou, Meng(#)(*); Wang, Zhen-zhen; Zhang, Fan; Deng, Jia-en; Li, Xia, Comparative genomic analysis reveals evolutionary characteristics and patterns of microRNA clusters in vertebrates, Gene, 2013.1.10, 512(2): 383~391

Zhang, Shaojun; Xu, Liangde; Wang, Fang; Wang, Hongzhi; Gong, Binsheng; Zhang, Fan; Li, Xia(*); Wang, Yadong, Genetic control of primary microRNA insight into cis- and trans-regulatory variations by RNA-seq, Gene, 2013.4.1, 517(2): 224~229

Kuo, P-Y; Leshchenko, V. V.; Fazzari, M. J.; Perumal, D.; Gellen, T.; He, T.; Iqbal, J.; Baumgartner-Wennerholm, S.; Nygren, L.; Zhang, F.; et.al, High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma, ONCOGENE, 2015.3.5, 34(10): 1231~1240 （IF：7.519）

Sullivan, Josefa M.; Badimon, Ana; Schaefer, Uwe; Ayata, Pinar; Gray, James; Chung, Chun-wa; von Schimmelmann, Melanie; Zhang, Fan; et.al, Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice, JOURNAL OF EXPERIMENTAL MEDICINE, 2015.10.19, 212(11): 1771~1781 （IF：11.991）

Zhang RuiJie; Li Xia; Jiang YongShuai; Liu GuiYou; Li ChuanXing; Zhang Fan; et.al, Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework, Science China Life Sciences, 2009.2, 52(2): 163~172

Mathur, Deepali; Riffo-Campos, Angela L.; Castillo, Josefa; Haines, Jeffery D.; Vidaurre, Oscar G.; Zhang, Fan; et.al, Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients, FRONTIERS IN CELLULAR NEUROSCIENCE, 2017.7.18, 11