基本信息科学研究教学研究
基本信息
教授/博导

一直从事癌症糖生物学和代谢组学的基础研究工作。作为黑龙江省优秀研究生团队和哈工大创新团队的成员，申请者在国内首次掌握并改进了高通量N-糖基化分析的关键技术，从血清、体外培养细胞和组织多个层面研究癌症特异改变的糖链分子和小分子代谢物，已经完成上千例的样品分析工作，并深入探讨其发生改变的分子机制。

科研方面，主持国家自然基金4项，中国博士后基金、教育部留学归国人员科研启动基因、深研院合作项目及省博士后启动基金等多项目。

担任国家自然基金项目一审匿名评审专家。已发表SCI论文30余篇，在Journalof Proteomics发表的论文作为杂志季度Top 25 hottest articles.


研究领域
主要从事糖组学和代谢组学的研究工作

1. Wang C, Nie H, Li Y, Liu G1, Wang X, Xing S, Zhang L, Chen X, Chen Y, Li Y. The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy andchemotherapy of NSCLC. Sci Rep. 2016 Jun 1;6:26526.（指导学生一作）

2. Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, Wenjuan Huo, Anshun He, Yuanfei Yao, Yu Jin, Youpeng Qu, Xue-Long Sun, Yu Li. Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyl transferases-IVa Regulation. Sci Rep. 2015; 5: 16007.

3. Xin Lu, Huan Nie, Yiqun Li, Chao Zhan, Xia Liu, Xiuyun Shi,Ming Shi, Yubao Zhang,Yu Li. Comprehensive Characterization and Evaluation of Hepatocellular Carcinoma by LC-MS Based Serum. Metabolomics, 2015, 11(5):1381-1393（指导学生一作）

4. Narla SN, Nie H, Li Y, Sun XL. Multi-dimensional glycan microarrays with glyco-macroligands. Glycoconj J. 2015 Oct;32(7):483-95.（指导学生一作）

5. Wang D, Nie H, Ozhegov E, Wang L, Zhou A, Li Y, Sun XL. Globally profiling sialylation status of macrophages upon statin treatment. Glycobiology. 2015 Sep;25(9):1007-15.（指导学生一作）

6. Huan Nie, Xin Lu, Yiqun Li, Xiuyun Shi, Kun Zhang, Yu Li.Comprehensive characterization and evaluation of hepatocellular carcinoma by LC–MS based metabolomics.2015 The 1st Asia-Pacific Joint Symposium on Life Sciences, POSTECH

7. Narla SN, Pinnamaneni P, Nie H, Li Y ,Sun XL,. BSA-boronic acid conjugate as lectin mimetics. Biochem Biophys Res Commun.2014; J443(2):562-7.2.371 2

8. Xia Liu, Huan Nie, Yubao Zhang, Yuanfei Yao, Alaiyi Maitikabili, Youpeng Qu, Shuliang Shi, Cuiying Chen, and Yu Li, Cell Surface-Specific N-Glycan Profiling in Breast Cancer, Plos One, 2013;8 (8): e72704. （指导学生一作）

9. Shi M, Wang S, Yao Y, Li Y, Zhang H, Han F, Nie H, Su J, Wang Z, Yue L, Cao J, Li Y. Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer. Sci Rep. 2014 Dec 18;4:7545.

10. Xu S, Wu H, Nie H, Yue L, Jiang H, Xiao S, Li Y.AIF downregulation and its interaction with STK3 in renal cell carcinoma. PLoS One. 2014 Jul 3;9(7):e100824.

11. Nie Huan, Yao Yuanfei, Ding Ning, Liu Xia, Qu Youpeng, Li Yu.The N-Glycomic research on the Serum Biomarkers of Breast Cancer. Clinical and Experimental Pharmacoogy and Physiology. 2013; （40）, Issue Supplement s1, 162.004

12. Xia Liu, Huan Nie, Xuelong Sun, Yu Li，The Study on the Alteration Mechanism of Specific N-glycan for Hepatocellular Carcinoma. 9thAnnual Midwest Carbohydrate and Glycobiology Symposium.2013,10, America, Toledo,23,

13. Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in Sialic Acid-Focused Glycomics. Journal of Proteomics. 2012; 75(11):3098-3112,

14. Ding N, Nie H, Sun X, Sun W, Qu Y, Liu X, Yao Y, Liang X, Chen CC, Li Y. Human Serum N-Glycan Profiles Are Age and Sex Dependent. Age Ageing. 2011; 40(5):568-75. .（指导学生一作）

15. Satya Nandana Narla, Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in the Synthesis and Biomedical Applications of Chain-End Functionalized Glycopolymers. Journ al of Carbohydrate Chemistry, 2012; 31(2):67-92,

16. Huan Nie, Xia Liu, Ying Han, Tingting Li, Youpeng Qu, Yu Li. Alteration of Cell Surface-Specific N-glycan for Hepatocellular Carcinoma by DSA-FACE. 2012年全国生物化学与分子生物学学术大会,2012,8,成都

17.Youtao Yu, Yubao Zhang, Jianran Hu, Hao Zhang , Shan Wang, Fang Han, Lei Yue, Youpeng Qu, Yao Zhang, Hongjian Liang, Huan Nie, Yu Li. MARVELD1 inhibited cell proliferation and enhance chemosensitivity via increasing expression of p53 and p16 i n hepatocellular carcinoma. Cancer Science. 2012;103(4):716-22. 3.896

18. 梁雪, 聂桓, 李钰.胰腺癌早期诊断肿瘤标志物的研究进展.实用肿瘤杂志，2011; 4:422-426；

19. Huan Nie,Ding ning,Sun wei,Yu Youtao ,Yu Yan,Zhang Yubao ,Qu Youpeng, Wang Shan, Li Yu. N-Glycomic Changes in Serum for the Discovery of Potential Biomarkers of Breast Cancer. 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, Shang Hai, 2009

20. Li R, Tian YY, Gao Y, Wang S, Nie H, Li Y. Silencing LRP1B with huge transcript by RNAi method. [Article in Chinese]Yi Chuan. 2009 Jan;31(1):36-42.

21. Peng J, Yang L, Yang F, Yang J, Yan Y, Nie H, Zhang X, Xiong Z, Jiang Y, Cheng F, Xu X, Chen S, Sun L, Li W, Shen Y, Shao Z, Liang X, Xu J, Jin Q. Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics. 2008; 91(1):78-87.

22. Yang J, Nie H, Chen L, Zhang X, Yang F, Xu X, Zhu Y, Yu J, Jin Q. Revisiting the Molecular Evolutionary History of Shigella spp. J Mol Evol. 2007; 64(1):71-9 （并列第一作者）

23. Nie H, Yang F, Zhang X, Yang J,et al. Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics. 2006; 7:173.

24. Xiong Z, Tang X, Yang F, Zhang X, Yang J, Chen L, Nie H, Yan Y, Jiang Y, Wang J, Xue Y, Xu X, Zhu Y, Dong J, An L, Wang X, Jin Q.Comparison of the virulence plasmid genomes of two strains of Shigella which lost the ability to bind Congo red.Sci China C Life Sci. 2006;49(2):141-8.

25. Liu W, Nie H, Wang S, et al.. Mapping a resistance gene in wheat cultivar Yangfu 9311 to yellow mosaic virus, using microsatellite markers. Theor Appl Genet. 2005; 111(4):651-7.

26. Wei-Hua LIU, Huan NIE, Zhen-Tian HE, Xiu-Lan CHEN, et al..Mapping of a Wheat Resistance Gene to Yellow Mosaic Disease by Amplified Fragment Length Polymorphism and Simple Sequence Repeat Markers. Journal of Integrative Plant Biology 2005; 47 (9): 1133－1139

27. Yang F, Yang J, Zhang X, Chen L, Jiang Y, Yan Y, Tang X, Wang J, Xiong Z, Dong J, Xue Y, Zhu Y, Xu X, Sun L, Chen S, Nie H, Peng J, Xu J, Wang Y, Yuan Z, Wen Y, Yao Z, Shen Y, Qiang B, Hou Y, Yu J, Jin Q.Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res. 2005; 33(19):6445-58.
28. Jiang Y, Yang F, Zhang X, Yang J, Chen L, Yan Y, Nie H, Xiong Z, Wang J, Dong J, Xue Y, Xu X, Zhu Y, Chen S, Jin Q.The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid. 2005; 54(2):149-59.

讲授课程
教学方面，主讲4门课程，其中研究生学位科1门“生物大分子结构与功能”，本科生必修课1门“生物化学”, 全校选修课1门“生命的化学”，全英文实验课1门“生物化学基础实验”。

教学效果优秀。连续多年A+

曾获校“青年教师教学基本功竞赛” 二等奖，校“研究生课程青年教师教学竞赛”二等奖。主编著作1部，已完成研究生课程教材讲义1部，参编“十二五”规划教材1部。并荣获2012年黑龙江省高校师德先进个人、校优秀工会工作者等荣誉。

招生信息
每年1-2名硕士生，1名博士生