职位副教授，硕士生导师
头像
武汉大学生命科学学院本科，博士；中国科学院动物所博士后，助理研究员；中山大学****副教授。主要从事核酸G四链体结构与功能的研究，在Nucleic Acids Res，J. Am. Chem. Soc，ACS Chem Biol，PNAS，Angew Chem Int Ed Engl上发表论文22篇，其中第一作者以及共同通讯作者论文13篇，累积影响因子大于80。第一作者和参与完成的两篇NAR被入选Faculty of 1000 Biology，一篇第一作者NAR入选Featured Article (现更名为Breakthrough Articles)。
2015年入选第一批中国科协青年人才托举工程（依托全国160多个学会，资助总人数约200人）。2016年入选中国科学院青年创新促进会会员。
电子邮箱Ktmm66@gmail.com/ktmm66@163.com
个人经历2019.2 –至今
中山大学药学院（深圳） 副教授
2013.9 – 2019.1
中国科学院动物研究所助理研究员
2011.7 – 2013.6
中国科学院动物研究所博士后
2006.9 – 2011.6
武汉大学生命科学学院生物化学与分子生物学博士
2002.9 – 2006.6
武汉大学生命科学学院本科
研究方向DNA或RNA高级结构与功能，核酸新靶点的发现
科研项目中国博士后基金面上基金第50批，2012
中国博士后基金特别资助第6批，2013
国家自然科学基金青年基金项目，2018-2020
中国科协青年人才托举工程第一批入选，2015-2017年
中国科学院青年创新促进会会员，2017-2020
代表论著1.?Zheng, K. W.?#; Zhang, J. Y. #; He, Y. D. #; Gong, J. Y.; Wen, C. J.; Chen, J. N.; Hao, Y. H.; Zhao, Y.; Tan, Z., Detection of genomic G-quadruplexes in living cells using a small artificial protein. Nucleic Acids Res?2020. （共同第一作者）
2.?Zheng, K. W. #; Liu, C. #; Meng, Q.; Hao, Y. H.; Zheng, J. P.; Li, W.; Tan, Z., One-Step High-Throughput Telomerase Activity Measurement of Cell Populations, Single Cells, and Single-Enzyme Complexes. ACS Omega?2020, 5 (38), 24666-24673. （共同第一作者）
3.?Wen CJ#, Gong JY#, Zheng KW*, He YD, Zhang JY, Hao YH, and Tan Z* (2020) Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. Chem Commun?(Camb), 56: 6567-6570.（共同通讯作者）
4.?He YD, Zheng KW*, Wen CJ, Li XM, Jiayuan G, Hao YH, Zhao Y, and Tan Z* (2020) Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate. J Am Chem Soc, **, 142, 26, 11394–11403.（共同通讯作者）
5.?Tan, Z.; Hao, Y. H.; Zheng, K. W. *, Kinetics, conformation, stability, and targeting of G-quadruplexes from a physiological perspective. Biochem Biophys Res Commun 2020, 531 (1), 84-87.（通讯作者）
6.?Zheng KW*, Zhang JY, and Tan Z (2019) Characterization of Co-transcriptional Formation of G-Quadruplexes in Double-Stranded DNA. Methods Mol Biol, 2035: 243-255.（论著，章节）
7. Xia, Ye#; Zheng, Ke-wei#*; He, Yi-de; Liu, Hong-he; Wen, Cui-jiao; Hao, Yuhua; Tan, Zheng*?(2018) “Transmission of Dynamic Supercoiling in Linear and Multi-Way Branched DNAs and Its Regulation Revealed by a Fluorescent G-Quadruplex Torsion Sensor.” Nucleic Acids Res,https://doi.org/10.1093/nar/gky534. (共同第一,共同通讯作者)
8. Zheng, K. W.?#, Y. D. He#, H. H. Liu, X. M. Li, Y. H. Hao and Z. Tan (2017). “Superhelicity Constrains a Localized and R-Loop-Dependent Formation of G-Quadruplexes at the Upstream Region of Transcription.” ACS Chem Biol?12(10): 2609-2618. （共同第一作者）
9. Li, X.M., Zheng, K.W.?*, Hao, Y.H. and Tan, Z.?*?(2016) Exceptionally Selective and Tunable Sensing of Guanine Derivatives and Analogues by Structural Complementation in a G-Quadruplex. Angew. Chem. Int. Ed. Engl., 55, 13759-13764. (共同通讯作者)
10. Li, X.M., Zheng, K.W.?*,?Zhang, J.Y., Liu, H.H., He, Y.D., Yuan, B.F., Hao, Y.H. and Tan, Z.?*?(2015) Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives. Proc. Natl. Acad. Sci. USA, 112, 14581-14586. (共同通讯作者)
11. Zheng, K.W., Wu, R.Y., He, Y.D., Xiao, S., Zhang, J.Y., Liu, J.Q., Hao, Y.H. and Tan, Z. (2014) A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic Acids Res, 42, 10832-10844. （第一作者）
12. Zheng, K.W., Xiao, S., Liu, J.Q., Zhang, J.Y., Hao, Y.H. and Tan, Z. (2013) Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. Nucleic Acids Res., 41, 5533-5541.(Featured Article)（第一作者）
13?.Zheng, K. W., D. Zhang, L. X. Zhang, Y. H. Hao, X. Zhou and Z. Tan (2011). "Dissecting the strand folding orientation and formation of G-quadruplexes in single- and double-stranded nucleic acids by ligand-induced photocleavage footprinting." J Am Chem Soc?133(5): 1475-1483. （第一作者）
14?.Zheng, K. W., Z. Chen, Y. H. Hao and Z. Tan (2010). "Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA." Nucleic Acids Res 38(1): 327-338.（第一作者）（Faculty of 1000 biology）
15.?Liu, H.h.,?Zheng, K.w., He, Y.d., Chen, Q., Hao, Y.h. and Tan, Z. (2016) RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation.?Chem. Sci., 7, 4573-4581.
16.?Wu, R.Y., Zheng, K.W., Zhang, J.Y., Hao, Y.H. and Tan, Z. (2015) Formation of DNA:RNA Hybrid G-Quadruplex in Bacterial Cells and Its Dominance over the Intramolecular DNA G-Quadruplex in Mediating Transcription Termination. Angew. Chem. Int. Ed. Engl., 54, 2447-2451.
17.?Xiao, S., Zhang, J.Y., Wu, J., Wu, R.Y., Xia, Y., Zheng, K.W., Hao, Y.H., Zhou, X. and Tan, Z. (2014) Formation of DNA:RNA Hybrid G-Quadruplexes of Two G-Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G-Quadruplexes in Genomes. Angew. Chem. Int. Ed. Engl., 53, 13110-13114.
18.?Zhang, J.Y., Zheng, K.W., Xiao, S., Hao, Y.H. and Tan, Z. (2014) Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA. J. Am. Chem. Soc., 136, 1381-1390.
19.?Zhang, C., Liu, H.H., Zheng, K.W., Hao, Y.H. and Tan, Z. (2013) DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix. Nucleic Acids Res., 41, 7144-7152.（Faculty of 1000 biology）
20.?Xiao, S., Zhang, J.Y.,?Zheng, K.W., Hao, Y.H. and Tan, Z. (2013) Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. Nucleic Acids Res., 41, 10379-10390.
21.?Xue, Y., Liu, J.Q.,?Zheng, K.W., Kan, Z.Y., Hao, Y.H. and Tan, Z. (2011) Kinetic and Thermodynamic Control of G-Quadruplex Folding. Angew. Chem. Int. Ed., 50, 8046-8050.
22.?Wang, Q., Liu, J.Q., Chen, Z., Zheng, K.W., Chen, C.Y., Hao, Y.H. and Tan, Z. (2011) G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase. Nucleic Acids Res., 39, 6229-6237.
23.?Chen, Z.,?K.W. Zheng, Y.H. Hao, & Z. Tan, (2009) Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition. J Am Chem Soc, 131: 10430-10438.
?
