职位副教授，硕士生导师
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薛永波，四川德阳人，九三学社社员，中山大学药学院（深圳）副教授，PI。2011年毕业于中国科学院昆明植物所，师从孙汉董院士。2011-2016年，先后任华中科技大学讲师、副教授。2017-2018年，任The University of Queensland化学与分子生命科学学院(SCMB)访问****，合作导师：Prof. Craig M Williams。2019年3月受聘中山大学“****”副教授，建立“现代中药与创新天然药物课题组”。他一直围绕新颖结构天然化合物的发现、化学结构与生物功能、天然先导物的挖掘与成药性研究等开展工作。在领域权威期刊Angewandte Chemie International Edition，Chemical Science，Organic Letters，Journal of Organic Chemistry，Organic Chemistry Frontiers，Journal of Natural Products等发表研究性SCIE论文120余篇；其中通讯作者和第一作者论文逾50篇；参与发现的12个新颖天然化合物被领域著名综述性期刊Natural Products Reports选为热点化合物。申请国家发明专利7项(已授权3项)。主持和参与国家级和国际科技合作研究项目二十余项。
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电子邮箱xueyb@mail.sysu.edu.cn; yongbo.xue@hotmail.com (本课题组长期招收特聘研究员、博士后、博/硕士研究生等)
个人经历2001.09-2005.07?大理大学（原大理医学院）药学专业，理学学士
2005.09-2008.07?大理大学/中科院昆植所（联培）药物化学专业，医学硕士
2008.09-2011.07?中科院昆明植物研究所药物化学专业，理学博士
2011.07-2016.10?华中科技大学同济医学院药学院中药与天然药物化学系，讲师，硕导
2016.11-2019.02?华中科技大学同济医学院药学院中药与天然药物化学系，副教授，硕导
2017.02-2018.02?昆士兰大学化学与分子生物科学学院，访问****
2019. 03- ????中山大学药学院（深圳）“****”副教授、硕导
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学术兼职
《Evidence-based Complementary and Alternative Medicine》Academimc editor；《Chinese Chemistry Letters》、《天然产物研究与开发》青年编委；广东省海洋创新联盟专家委员；国家自然科学基金项目、广东省自然科学基金项目通讯评审专家；中国植物学会会员、中国药学会会员、美国化学会会员、中国化学会会员；Organic Letters, Organic Chemistry Frontiers, Journal of Natural Products, European Journal of Medicinal Chemistry, Phytochemistry, Food & Function, Science of The Total Environment, Journal of Ethnopharmacology, Phytomedicine, Frontiers in Microbiology, Evidence-based Complementary and Alternative Medicine,Bioorganic Chemistry, Natural Product Research, Chemistry & Biodiversity, Fitoterapia, Chinese Chemical Letters, Helvetica Chimica Acta, Journal Of Natural Medicines等近30种SCIE学术期刊特邀审稿人。
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研究方向中药及天然药物化学、化学生物学：
（1）海洋生物新颖活性物质的结构与生物功能研究
（2）中药药用植物及其内生菌的化学物质基础研究
（3）天然先导化合物结构改造、优化和成药性研究
（4）开展天然有机化合物为探针的化学生物学研究
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科研项目（1）深圳市科技计划基础研究项目（重点项目）；角色：负责人；项目编号：JCYJ215045；金额：250万；期限：2020.11-2023.11
（2）中山大学“****二期”启动基金；角色：负责人；项目编号：75；金额：60万；期限：2019.03-2020.12
（3）国家自然科学基金面上项目；角色：负责人；项目编号：**；金额：66万；期限：2020.01-2023.12
（4）国家自然科学基金面上项目；角色：负责人；项目编号：**；金额：60万；期限：2018.01-2021.12
（5）国家自然科学基金应急项目；角色：负责人；项目编号：**；金额：10万；期限：2017.01-2017.12
（6）国家自然科学基金青年项目；角色：负责人；项目编号：**；金额：22万；期限：2013.01-2015.12
（7）国家级大学生创新训练计划项目；角色：创新团队导师；项目编号：0；期限：2016.01-2016.12
（8）国家留学基金管理委员会国家公派访问****项目；角色：负责人；项目编号：1；期限：2017.01-2018.01
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代表论著
（ORCID：https://orcid.org/0000-0001-9133-6439）
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[1]? Tan YP, Xue Y, Savchenko AI, Houston SD, Modhiran N, McMillan CLD, Boyle GM, Bernhardt PV, Young PR, Watterson D, Williams CM. Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon. J. Nat. Prod. 2019; 82: 2828–34. DOI: 10.1021/acs.jnatprod.9b00522
[2]? Zhang N, Shi Z, Guo Y, Xie S, Qiao Y, Li XN, Xue Y, Luo Z, Zhu H, Chen C, Hu L, Zhang Y: The Absolute Configurations of Hyperilongenols A–C: Rare 12,13-Seco-Spirocyclic Polycyclic Polyprenylated Acylphloroglucinols with Enolizable β,β’-Tricarbonyl Systems from Hypericum longistylum Oliv. Org. Chem. Front. 2019; 6: 1491–502. DOI:10.1039/C9QO00245F.
[3]? Guo Y, Tong Q, Zhang N, Duan X, Cao Y, Zhu H, Xie S, Yang J, Zhang J, Liu Y, Xue Y, Zhang Y: Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis. Org. Chem. Front. 2019; 6: 871–24. DOI:10.1039/C8QO01268G.
[4]? Guo Y, Zhang N, Duan X, Cao Y, Xue Y, Luo Z, Zhu H, Chen C, Wang J, Zhang Y: Hyperforatins L–U: Prenylated acylphloroglucinols with a terminal double bond from Hypericum perforatum L. (St John's Wort). Phytochemistry 2019; 164: 41–9. DOI: 10.1016/j.phytochem.2019.04.011.
[5]? Qiao Y, Xu Q, Feng W, Tao L, Li X-N, Liu J, Zhu H, Lu Y, Wang J, Qi C, Xue Y, Zhang Y: Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway. J. Nat. Prod. 2019; 82: 2925-30. DOI: 10.1021/acs.jnatprod.9b00188.
[6]? Duan Y, Xie S, Guo Y, Qiao Y, Shi Z, Tao L, Deng M, Cao Y, Xue Y, Qi C, Zhang Y:Przewalcyrones A-F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim. Org. Biomol. Chem. 2019; 17: 8234–42. DOI: 10.1039/c9ob01500k.
[7]? Qiao Y, Liu Y, Duan X, Chen C, Liu J, Zhu H, Xue Y, Zhang Y: A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala. Tetrahedron 2018; 74: 3852–57. DOI:10.1016/j.tet.2018.05.028.
[8]? Xie S, Wu Y, Qiao Y, Guo Y, Wang J, Hu Z, Zhang Q, Li X, Huang J, Zhou Q, Luo Z, Liu J, Zhu H, Xue Y, Zhang Y: Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A. J. Nat. Prod. 2018; 81: 1311–20. DOI:10.1021/acs.jnatprod.7b00889.
[9]? Li H, Sun W, Deng M, Qi C, Chen C, Zhu H, Luo Z, Wang J, Xue Y, Zhang Y: Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor. Mar. Drugs 2018; 16: 177. DOI:10.3390/md**.
[10]????? Li H, Sun W, Deng M, Zhou Q, Wang J, Liu J, Chen C, Qi C, Luo Z, Xue Y, Zhu H, Zhang Y: Asperversiamides, Linearly Fused Prenylated Indole Alkaloids from the Marine-Derived Fungus Aspergillus versicolor. J. Org. Chem. 2018; 83: 8483–92. DOI:10.1021/acs.joc.8b01087.
[11]????? Guo Y, Zhang N, Sun W, Duan X, Zhang Q, Zhou Q, Chen C, Zhu H, Luo Z, Liu J, Li XN, Xue Y, Zhang Y: Bioactive Polycyclic Polyprenylated Acylphloroglucinols from Hypericum perforatum. Org. Biomol. Chem. 2018; 16: 8130–43. DOI:10.1039/C8OB02067A.
[12]????? He Y, Zheng M, Li Q, Hu Z, Zhu H, Liu J, Wang J, Xue Y, Li H, Zhang Y: Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1. Org. Chem. Front. 2017; 4: 1137–44. DOI:10.1039/C6QO00847J.
[13]????? Zhu H, Chen C, Tong Q, Yang J, Wei G, Xue Y, Wang J, Luo Z, Zhang Y: Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System from Aspergillus flavipes QCS12. Angew. Chem. Int. Ed. 2017; 129: 5242–46. DOI:10.1002/ange..
[14]????? Guo Y, Zhang N, Chen C, Huang J, Li XN, Liu J, Zhu H, Tong Q, Zhang J, Luo Z, Xue Y, Zhang Y: Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum. J. Nat. Prod. 2017; 80: 1493–504, DOI:10.1021/acs.jnatprod.6b01178.
[15]????? Hu Z, Wu Y, Xie S, Sun W, Guo Y, Li XN1, Liu J, Li H, Wang J, Luo Z, Xue Y, Zhang Y: Phomopsterones A and B, Two Highly Functionalized Ergostane-type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A, Org. Lett. 2017; 19(1): 258–61. DOI: 10.1021/acs.orglett.6b03557.
[16]????? He Y, Hu Z, Sun W, Li Q, Li XN, Zhu H, Huang J, Liu J, Wang J, Xue Y, Zhang Y: Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. J. Org. Chem. 2017; 82(6): 3125–31. DOI:10.1021/acs.joc.7b00056.
[17]????? Tang Y, Xue Y, Du G, Wang J, Liu J, Sun B, Li XN, Yao G, Luo Z, Zhang Y: Structural revisions of a class of natural products: scaffolds of aglycon analogs of fusicoccins and cotylenins isolated from fungi. Angew. Chem. Int. Ed. 2016; 55: 4069–73. DOI: 10.1002/anie..
[18]????? Zhu H, Chen C, Tong Q, Li XN, Yang J, Xue Y, Luo Z, Wang J, Yao G, Zhang Y: Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew. Chem. Int. Ed. 2016; 47: 3486–90. DOI:10.1002/anie..
[19]????? Qi C, Bao J, Wang J, Zhu H, Xue Y, Wang X, Li H, Sun W, Gao W, Lai Y, Chen JG, Zhang Y: Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Chem. Sci. 2016; 7: 6563–72. DOI:10.1039/C6SC02464E.
[20]????? Qiao Y, Xu Q, Hu Z, Li XN, Xiang M, Liu J, Huang J, Zhu H, Wang J, Luo Z, Xue Y, Zhang: Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 2016; 79 (12): 3134–42. DOI: 10.1021/acs.jnatprod.6b00910.
[21]????? Hu L, Xue Y, Zhang J, Zhu H, Chen C, Li XN, Liu J, Wang Z, Zhang Y, Zhang Y: (±)-Japonicols A–D, Acylphloroglucinol-based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum. J. Nat. Prod. 2016; 79: 1322–8. DOI: 10.1021/acs.jnatprod.5b01119.
[22]????? Zhu H, Chen C, Xue Y, Tong Q, Li XN, Chen X, Wang J, Yao G, Luo Z, Zhang Y: Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angew. Chem. Int. Ed. 2015; 54: 13374–8. DOI: 10.1002/anie..
[23]????? Chen C, Zhu H, Li XN, Yang J, Wang J, Li G, Li Y, Tong Q, Yao G, Luo Z, Xue Y, Zhang Y.: Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org. Lett. 2015; 17(3): 644–7. DOI: 10.1021/ol503666b.
[24]????? Lu Y, Xue Y, Liu J, Yao G, Li D, Sun B, Zhang J, Liu Y, Qi C, Xiang M, Luo Z, Du G, Zhang Y: (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii. J. Nat. Prod. 2015; 78(9): 2205–14. DOI:10.1021/acs.jnatprod.5b00328.
[25]????? Chen C, Wang J, Liu J, Zhu H, Sun B, Wang J, Zhang J, Luo Z, Yao G1, Xue Y, Zhang Y: Armochaetoglobins A–J: cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgare. J. Nat. Prod. 2015; 78(6): 1193–201. DOI: 10.1021/np500626x.
[26]????? Xue Y, Li X, Du X, Li X, Wang W, Yang J, Chen J, Pu J, Sun H: Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis. Phytochemistry 2015; 116: 253–61. DOI: 10.1016/j.phytochem.2015.03.009.
[27]????? Zhu H, Chen C, Yang J, Li XN, Liu J, Sun B, Huang SX, Li D, Yao G, Luo Z, Li Y, Zhang J, Xue Y, Zhang Y: Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii. Org. Lett. 2014; 16: 6322–5. DOI: 10.1021/ol**.
[28]????? Zeng J, Xue Y, Shu P, Qian H, Sa R, Xiang M, Li XN, Luo Z, Yao G, Zhang Y: Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia. J. Nat. Prod. 2014; 77(8): 1448–54. DOI: 10.1021/np500465g.
[29]????? Zhang M, Zhu Y, Zhan G, Shu P, Sa R, Lei L, Xiang M, Xue Y, Luo Z, Wan Q, Yao G, Zhang Y. Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum. Org. Lett. 2013; 15:3094–7. DOI:10.1021/ol401292y.
[30]????? Xue YB, Yang JH, Li XN, Du X, Pu JX, Xiao WL, Su J, Zhao W, Li Y, Sun HD: Henrischinins A–C: three new triterpenoids from Schisandra henryi. Org. Lett. 2011; 13: 1564–7. DOI: 10.1021/ol200283y.
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