陈耀庆

中山大学公共卫生学院（深圳） 教授



电子邮件
chenyaoqing@mail.sysu.edu.cn



博士生导师，中山大学****引进人才
?
研究方向1. 病毒感染与体液免疫应答
2. B细胞的分化与亲和力成熟机制
3. 人源单克隆抗体的研发和临床应用
4. 新型流感疫苗的设计与优化?
?
工作经历2018/10-至今???????? 中山大学公共卫生学院（深圳），教授
2017/06-2018/09?? 芝加哥大学医学院，研究专员????
2013/06-2017/05?? 芝加哥大学医学院，博士后
2012/09-2013/05?? 明尼苏达州立大学药学院，博士后
?
教育经历2006/09-2012/05?? 武汉大学/中国科学院武汉病毒研究所，微生物，理学博士
2002/09-2006/07? 武汉大学，生物技术基地班，理学学士
?
研究简介? ? ?本课题组主要研究病毒感染或疫苗接种后机体的体液免疫应答机制，研究对象主要包括流感病毒，登革热病毒等新发与再发病原微生物，将综合运用免疫学，病毒学，结构生物学与生物信息学等多学科方法，以高通量人源单抗筛选平台为基础，深入剖析病毒感染后B细胞体液免疫应答的分子机制，为疫苗设计与优化提供理论基础。与此同时，研究与开发临床的人源治疗性的抗病毒单克隆抗体。已在免疫学与病毒学研究领域的国际知名杂志上发表多篇SCI文章，包括Cell，Nature Microbiology, Journal of Virology，Cell Host & Microbe等。
主要承担课题及人才项目国家自然科学基金面上项目（2020-2023），在研，主持
深圳市科技创新委员会重点研发项目（2020-2023），在研，核心参与
深圳市科技创新委员会面上项目（2020-2023），在研，主持
中山大学青年教师重点培育计划（2019-2020），在研，主持
中山大学****中青年杰出人才（2018-2020），在研，主持
发表论文Chen Y, Wohlbold T, Zheng N, Huang M, Huang Y, Neu K, Lee J, Wan H, Rojas K, Kirkpatrick E, Henry C, Palm A, Stamper C, Lan L, Topham D, Treanor J, Wrammert J, Ahmed R, Eichelberger M, Georgiou G, Krammer F, Wilson P. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell. 173(2): 417-429, 2018
Chen Y, Lan L, Huang M, Henry C, Wilson P. Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance.?Journal of Virology?93(4), 2019?
Chen Y, Rajashankar K, Yang Y, Agnihothram S, Liu C, Lin Y, Baric R, Li F. Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. Journal of Virology?87(19): 10777-10783, 2013
Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z, Yan H. Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. PloS one. 7(4), 2012
Guthmiller JJ, Lan LY, Fernández-Quintero ML, Han J, Utset HA, Bitar DJ, Hamel NJ, Stovicek O, Li L, Tepora M, Henry C, Neu KE, Dugan HL, Borowska MT, Chen YQ, Liu STH, Stamper CT, Zheng NY, Huang M, Palm AE, García-Sastre A, Nachbagauer R, Palese P, Coughlan L, Krammer F, Ward AB, Liedl KR, Wilson PC. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.?Immunity. 2020 Dec 15;53(6):1230-1244.e
Dugan HL, Guthmiller JJ, Arevalo P, Huang M, Chen YQ, Neu KE, Henry C, Zheng NY, Lan LY, Tepora ME, Stovicek O, Bitar D, Palm AE, Stamper CT, Changrob S, Utset HA, Coughlan L, Krammer F, Cobey S, Wilson PC. Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans. Science Translational Medicine. 2020 Dec 9;12(573):eabd3601.
Cao Z, Tang F, Chen C, Zhang C, Guo Y, Lin R, Huang Z, Teng Y, Xie T, Xu Y, Song Y, Wu F, Dong P, Luo G, Jiang Y, Zou H, Chen YQ, Sun L, Shu Y, Du X. Impact of Systematic Factors on the Outbreak Outcomes of the Novel COVID-19 Disease in China: Factor Analysis Study.?Journal of Medical Internet Research?2020 Nov 11;22(11):e23853.
Wan H, Gao J, Yang H, Yang S, Harvey R,?Chen YQ, Zheng NY, Chang J, Carney PJ, Li X, Plant E, Jiang L, Couzens L, Wang C, Strohmeier S, Wu WW, Shen RF, Krammer F, Cipollo JF, Wilson PC, Stevens J, Wan XF, Eichelberger MC, Ye Z. The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. Nature Microbiology.?2019, doi: 10.1038/s41564-019-0522-6.
Henry C, Zheng NY, Huang Mb, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE,?Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE11, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC. ,Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals., Cell Host & Microbe., 2011.24, 25(1-10)
Henry C, Palm AE, Utset HA, Huang M, Ho IY, Zheng NY, Fitzgerald T, Neu KE,?Chen YQ, Krammer F, Treanor JJ, Sant AJ, Topham DJ, Wilson PC. Monoclonal antibody responses after recombinant HA vaccine versus subunit inactivated influenza virus vaccine: a comparative study. Journal of Virology?2019 Aug 21. pii: JVI.01150-19.
Veselits M, Tanaka A,?Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill S, Wilson P, Sciammas R, Clark M. Igbeta ubiquitination activates PI3K signals required for endosomal sorting. The Journal of experimental medicine.?214(12): 3775-3790,2017
Yang J, Zhang E, Liu F, Zhang Y, Zhong M, Li Y, Zhou D,?Chen Y, Cao Y, Xiao Y, He B, Yang Y, Sun Y, Lu M, Yan H. Flagellins of Salmonella Typhi and nonpathogenic Escherichia coli are differentially recognized through the NLRC4 pathway in macrophages. Journal of innate immunity.?6(1): 47-57, 2014
Du L, Kou Z, Ma C, Tao X, Wang L, Zhao G,?Chen Y, Yu F, Tseng C T, Zhou Y, Jiang S. A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. PloS one. 8(12),2013?
Yang J, Zhong M, Zhang Y, Zhang E, Sun Y, Cao Y, Li Y, Zhou D, He B,?Chen Y, Yang Y, Yu J, Yan H. Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization. Human vaccines & immunotherapeutics. 9(5): 1084-1092, 2013
Zhong M, He B, Yang J, Bao R, Zhang Y, Zhou D,?Chen Y, Li L, Han C, Yang Y, Sun Y, Cao Y, Li Y, Shi W, Jiang S, Zhang X, Yan H. L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide. Antimicrobial agents and chemotherapy. 56(6): 3121-3132, 2012
Sun Y, Shi W, Yang J, Zhou D,?Chen Y, Zhang Y, Yang Y, He B, Zhong M, Li Y, Cao Y, Xiao Y, Li W, Yu J, Li Y, Fan M, Yan H. Flagellin-PAc fusion protein is a high-efficacy anti-caries mucosal vaccine. Journal of dental research.?91(10): 941-947, 2012
Zhang Y, Yang J, Bao R,?Chen Y, Zhou D, He B, Zhong M, Li Y, Liu F, Li Q, Yang Y, Han C, Sun Y, Cao Y, Yan H. Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses. PloS one. 6(9), 2011
Zhou D, Zhang Y, Li Q,?Chen Y, He B, Yang J, Tu H, Lei L, Yan H. Matrix protein-specific IgA antibody inhibits measles virus replication by intracellular neutralization. Journal of Virology?85(21): 11090-11097, 2011
Shi W, Li Y, Liu F, Yang J, Zhou D,?Chen Y, Zhang Y, Yang Y, He B, Han C, Fan M, Yan H. Flagellin enhances saliva IgA response and protection of anti-caries DNA vaccine. Journal of dental research.?91(3): 249-254, 2012
Li Q, Zhao Z, Zhou D,?Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W. Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses. Peptides.?32(7): 1518-1525, 2011
Liu F, Yang J, Zhang Y, Zhou D,?Chen Y, Gai W, Shi W, Li Q, Tien P, Yan H. Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy. Biochemical and biophysical research communications. 392(4): 582-587, 2010
?
招生信息? ? ? ?陈耀庆教授团队热忱欢迎热爱科学研究的优秀学生报考硕士生和博士生（2-4人/年）；接收本科生进行科研培训实习（1-2人）；招收博士后以及专职科研人员（特聘研究员、特聘副研究员、助理研究员等），业绩优秀者聘期结束后可直接申报中山大学副教授/教授岗位。欢迎对病毒学、免疫学、生物信息学、预防医学、抗体临床运用等研究方向感兴趣的有志之士加入本实验室！请有意者将个人简历通过电子邮件发至：chenyaoqing@mail.sysu.edu.cn?，来信请注明申请方向及职位。