付国 教授
现工作单位：
细胞应激生物学国家重点实验室
厦门大学生命科学学院 (黄朝阳楼)
福建省厦门市翔安区翔安南路
邮政编码： 361102
手机电话： **
办公电话：
电子邮箱: guofu@xmu.edu.cn
个人信息
出生日期: 1973年1月
出生地点: 中国 辽宁 沈阳

工作经历
2014 年 10 月 - 现在教授; 细胞应激生物学国家重点实验室 厦门大学生命科学学院
2010 年 9 月 - 2014 年 8 月 Staff Scientist; 美国 Scripps 研究所，免疫和微生物科 学系
2009 年 9 月 - 2010 年 9 月高级博士后; 美国 Scripps 研究所，免疫和微生物科学系
2004 年 10 月 - 2009 年 9 月 博士后; 美国 Scripps 研究所，免疫和微生物科学系
1998 年 7 月 - 1999 年 6 月助教; 中国沈阳，中国医科大学, 免疫教研室。
学历背景
1999 年 6 月 - 2004 年 8 月 博士学位，澳大利亚墨尔本大学，微生物和免疫学系。(导师: Richard Strugnell教授. 毕业论文: The mRNA differential display of genes in dendritic cells following interaction with Salmonella typhimurium)
1995 年 9 月 - 1998 年 7 月 硕士学位, 中国沈阳，中国医科大学, 免疫教研室。(导师: 吕昌龙教授. 毕业论文: The role of p15 and p16 genes in childhood acute lymphocytic leukemia)
1991 年 9 月 - 1995 年 7 月学士学位, 中国沈阳，辽宁大学，生物系
发表文章
1. Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller S, Simister P, Molder KC, Cordoba S, Dushek O, Malissen B, Acuto O. A THEMIS:SHP complex promotes T cell survival. EMBO J. 2014 Dec 22. pii: e. (http://www.ncbi.nlm.nih.gov/pubmed/**)
2. Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor. Nature Communication. 2014 Nov 27;5:5624. doi: 10.1038/ncomms6624. (http://www.ncbi.nlm.nih.gov/pubmed/**)
3. Fu G, Rybakin V, Brzostek J, Paster W, Acuto O, Gascoigne NR. Fine- tuning T cell receptor signaling to control T cell development. Trends in Immunology. 2014 Jul;35(7):311-318. doi: 10.1016/j.it.2014.05.003. Epub 2014 Jun 17. Review.
(http://www.ncbi.nlm.nih.gov/pubmed/**)
4. Kong KF*, Fu G*, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio A, Becart S, Kim G, Yates JR 3rd, Kronenberg M, Saito T, Gascoigne NR, Altman A. Protein Kinase C-η Controls CTLA-4-Mediated Regulatory T Cell Function. *Equal contribution. Nature Immunology. 2014 May;15(5):465-72. doi: 10.1038/ni.2866. Epub 2014 Apr 6. (http://www.ncbi.nlm.nih.gov/pubmed/**)
5. Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier L. Costimulatory Molecule DNAM-1 Is Essential for Optimal
Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection. Immunity. 2014 Feb 20;40(2):225-34. doi: 10.1016/j.immuni.2013.12.011. (http://www.ncbi.nlm.nih.gov/pubmed/**)
6. Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JAH, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR. Themis sets the signal threshold for positive and negative selection in
T cell development. Nature. 2013 Dec 19;504(7480):441-5. doi:
10.1038/nature12718. (http://www.ncbi.nlm.nih.gov/pubmed/**)
7. Mukherjee S, Rigaud S, Seok S-C, Fu G, Prochenka A, et al. In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness. PLoS ONE. 2013, 8(9): e73937. doi:10.1371/journal.pone.**. (http://www.ncbi.nlm.nih.gov/pubmed/**)
8. Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riao A, Hoerter JA, Feller SM, Wülfing C, Gascoigne NR, Acuto O. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. Journal of Immunology. 2013 Apr 1;190(7):3749-56. (http://www.ncbi.nlm.nih.gov/pubmed/**) 9. Fu G, Gascoigne NR. The role of Protein Kinase Cη in T cell biology. Frontiers in Immunology. 2012;3:177. (http://www.ncbi.nlm.nih.gov/pubmed/**)
10. Gascoigne NR, Fu G. Tespa1: another gatekeeper for positive selection. Nature Immunology, 2012 May 18;13(6):530-2.
(http://www.ncbi.nlm.nih.gov/pubmed/**)
11. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. Journal of Clinical Investigation. 2012 Mar 1;122(3):963-73. (http://www.ncbi.nlm.nih.gov/pubmed/**)
12. Fu G#, Gascoigne NR#. Protein kinase C η, an emerging player in T cell biology. Cell Cycle. 2012, Mar 1;11(5). #Co-corresponding author. (http://www.ncbi.nlm.nih.gov/pubmed/**)
13. Fu G#, Hu J, Niederberger-Magnenat N, Rybakin V, Casas J, Yachi PP, Feldstein S, Ma B, Hoerter JAH, Ampudia J, Rigaud S, Lambolez F, Gavin AL, Sauer K, Cheroutre H, Gascoigne NRJ#. Protein Kinase C η
付国教授 Is Required for T Cell Activation and Homeostatic Proliferation. Science Signaling. 2011 Dec 6;4(202):ra84. #Co-corresponding author. (http://www.ncbi.nlm.nih.gov/pubmed/**)
14. Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, McGowan S, Fu G, Gascoigne NR, Acuto O, Salek M. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. Journal of Biological Chemistry. 2011 Mar 4;286(9):7535-47. (http://www.ncbi.nlm.nih.gov/pubmed/**)
15. Fu G#, Gascoigne NR#. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. Journal of Immunological Methods. 2009 Oct 31;350(1-2):194-9. #Co-corresponding author. (http://www.ncbi.nlm.nih.gov/pubmed/**)
16. Fu G*, Vallée S*, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature Immunology. 2009 Aug;10(8):848-56. *Equal contribution. (http://www.ncbi.nlm.nih.gov/pubmed/**)
17. Gascoigne NR, Ampudia J, Clamme JP, Fu G, Lotz C, Mallaun M, Niederberger N, Palmer E, Rybakin V, Yachi PP, Zal T. Visualizing intermolecular interactions in T cells. Current Topics in Microbiology and Immunology. 2009;334:31-46. Review.
(http://www.ncbi.nlm.nih.gov/pubmed/**)
18. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Spatiotemporal patterning during T cell activation is highly diverse. Science Signaling. 2009 Apr 7;2(65):ra15. (http://www.ncbi.nlm.nih.gov/pubmed/**)
19. Fu G, Wijburg OL, Cameron PU, Price JD, Strugnell RA. Salmonella enterica Serovar Typhimurium infection of dendritic cells leads to functionally increased expression of the macrophage-derived chemokine. Infection and Immunity. 2005 Mar;73(3):1714-22. (http://www.ncbi.nlm.nih.gov/pubmed/**)
20. Fu G, Lu C, Zhang R. Deletions and aberrant transcription of p16 and p15 genes in childhood acute lymphoblastic leukemia. Zhonghua Xue Ye Xue Za Zhi. 1999 Jul;20(7):366-8. Chinese. (http://www.ncbi.nlm.nih.gov/pubmed/**)
主要讲座
2014 年 11 月, 中国上海, Treg/Th17 conference
2014 年 4 月，新加坡，南洋理工大学
2014 年 3 月，中国福建，厦门大学

2014 年 3 月，中国香港，香港科技大学
2014 年 3 月，美国，南卡罗莱纳医科大学
2014 年 3 月，美国加利福尼亚州，Asilomar，Midwinter Conference of Immunologists,
2013 年 12 月，中国上海，上海科技大学
2013 年 10 月，美国加利福尼亚州，La Jolla， La Jolla Immunology Conference
2011 年 12 月，美国加利福尼亚州，San Diego， BD Biosciences
2010 年 3 月，美国科罗拉多州，Breckenridge，Keystone Symposium on “Lymphocyte Activation and Gene Expression”
2008 年 4 月，美国加利福尼亚州，San Diego，The American Association of Immunologists annual meeting
主要获奖经历
2013 年 10 月，The American Association of Immunologists Young Investigator award