Pinglong Xu Ph.D.
Professor & Principal Investigator Life Sciences Institute and Innovation Center for Cell Biology
Zhejiang University
Address: Nano Building, Room 555 Life Sciences Institute Zhejiang University 866 Yuhangtang Road
Hangzhou, Zhejiang 310058, China
Voice: 86-
E-mail: xupl@zju.edu.cn


EDUCATION:
2004-10 University of California - San Francisco
Mentor: Prof. Rik Derynck Postdoctoral rainingSignal Transduction and Cancer
1998-03 Shanghai Institute of Biochemistry, Chinese Academy of Sciences
Mentor: Prof. Yuan Wang
Ph.D. Biochemistry and Molecular Biology
1994-98 Sichuan University B.S. Biochemistry
RESEARCH EXPERIENCE
2013-present
Professor & Principal Investigate
Zhejiang University
Life Sciences Institute
Projects 1) Non-canonical Smad signaling in cancer metastasis;
2) (De)phosphorylation modification during innate antiviral response;
3) Cytokine signaling in self-renewal of CSCs.
2011-2013
Assistant Cell Biologist (Research-track faculty)
University of California - San Francisco
Department of Cell and Tissue Biology
Projects 1) Innate antiviral host defense in regulation of TGF-? signaling and functions;
2) Regulatory signal network in control of regulatory T lymphocyte differentiation.
2004-10
Postdoctoral Research Fellow
University of California - San Francisco
Department of Cell and Tissue Biology
Projects 1) Inflammatory cytokines and growth factor signaling in regulation of tumorigenesis;
2) Molecular mechanism of metalloproteinase TACE/ADAM17 activation in response to MAPK signal.
1998-04
Graduate Research Assistant and Research Associate
Shanghai Institute of Biochemistry, Chinese Academy of Sciences
State Key Laboratory of Molecular Biology
Project 1) Molecular mechanism of transcriptional activation by orphan nuclear receptor LRH-1;
2) Liver specific transcriptional factors in regulation of Hepatitis B virus replication.

KEYWORDS/AREAS OF INTEREST:
TGF-b, innate antiviral host defense, ADAM metalloproteinase, epithelial to mesenchymal transition, Treg, cancer metastasis, cell signaling.
FUNDING SUPPORTS:
1) Research Foundation for the Returned Overseas Talents of Zhejiang University, 2014.1 - 2018.12, US$ 800k
2) MOST 973 plan (2015CB553800), 2015.1 - 2019.6, US$ 300k
3) NSFC project (**), 2015.1 - 2018.12, US$ 120k
4) Fundamental Research Funds of the Central Universities (2014QN81002), 2014.1 - 2014.12, US$ 42k
PROFESSIONAL ORGANIZATIONS:
Memberships
2013-present Chinese Society for Cell Biology
2010-present American Association for Cancer Research
2009-present American Heart Association
2009-present Sigma ?i, The Scientific Research Society
2013-present Chinese Society for Cell Biology
Service to professional publications (ad hoc reviewer):
Oncogene
Cancer Letters
Molecular Immunology
Journal of Cellular Biochemistry
Development Growth & Differentiation
International Journal of Biological Sciences
FEBS Journal
PEER-REVIEWED PUBLICATIONS:
1) Pinglong Xu*, Samantha Bailey-Bucktrout, Ying Xi, Daqi Xu, Dan Du, Qian Zhang, Weiwen Xiang, Jianming Liu, Andrew Melton, Dean Sheppard, Harold A. Chapman, Jeffery A. Bluestone, and Rik Derynck*. Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. Molecular Cell, 2014, 56(6): 723-737. (*, corresponding authors.)
(Previewed of this article by Dr. Richard Flavell: Resemble and Inhibit: When RLR Meets TGF-β, Molecular Cell, 2014, 56(6): 719-720.)
2) Pinglong Xu, Jianming Liu, Masayo Yumoto and Rik Derynck. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Science Signaling, 2012, 5(222): research article ra34.
3) Pinglong Xu, Jianming Liu, and Rik Derynck. Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Letters, 2012, 586(14): 1872-84.
(Invited review in special issue: Sorting the TGF-β labyrinth.)
4) Pinglong Xuand Rik Derynck. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Molecular Cell, 2010, 37(4):551-66.
(Recommended of this article by Faculty of 1000)
5) Cheng Liu#, Pinglong Xu#, Samy Lamouille, Jian Xu, and Rik Derynck. TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling. Molecular Cell, 2009, 35(1):26-36. (* co-first author.)
(Highlight of this article in Science Signaling as Editor’s Choice: Another TGF-β Desensitization Strategy. Science Signaling, 2009, 2(80):p.ec247)
6) Ping-Long Xu, Yun-Qin Liu, Shi-Fang Shan, Yu-Ying Kong, Qing Zhou, Mei Li, Jian-Ping Ding, You-Hua Xie, and Yuan Wang. Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homologue 1 by steroid receptor coactivator-1. Molecular Endocrinology, 2004,18(8):1887-905
7) Xu Ping-Long, Shan Shi-Fang, Kong Yu-Ying, Xie You-Hua, and Wang Yuan. Characterization of a strong repression domain in the hinge region of orphan nuclear receptor hB1F/LRH-1. Acta Biochimica et Biophsica Sinica, 2003, 35 (10): 909-916
8) Xu Ping-Long, Kong Yu-Ying, Xie You-Hua, and Wang Yuan. Corepressor SMRT specifically represses the transcriptional activity of orphan nuclear receptor hB1F/LRH-1. Acta Biochimica et Biophsica Sinica, 2003, 35 (10) : 897-903
9) Cheng-Kang Zhang, Wei Lin, Yan-Ning Cai, Ping-Long Xu, Hui Dong, Mei Li, Yu-Ying Kong, Gang Fu, You-Hua Xie, Guyang Matthew Huang, and Yuan Wang. Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene. Gene, 2001, 273 (2): 239-249
10) Bao Jin-Ku, Wu Chuan-Fang, Lu Hui, Zhou Hong, Zeng Zhong-Kui, Xu Ping-Long, and Zou Jian. The effect of metal ion and denaturant on conformation and function of Polygonatum cyrtonema Hua. Lectin II. Journal of Sichuan University, 2000, 12(6): 112-117
11) Bao Jin-Ku, Xu Ping-Long, Zhou Hong, Zeng Zhong-Kui, and Zou Jian. The relation between chemical modification tyrosine and biological activity of Polygonatum cyrtonema Hua. Lectin II. Chinese Journal of Biochemistry and Molecular Biology, 2000, 16(1):142-146
PRESENTATIONS:
Pinglong Xu. Innate Host Defense in Regulation of TGF-b Signaling and Cancer Metastasis. 2nd National Conference of Development Biology, 2014.10, Lanzhou, China. (Invited Speaker)
Pinglong Xu. Innate host defense and TGF-b function. International Forum of Life Sciences in Frontier, 2014.7, Chengdu, China. (Invited Speaker)
Pinglong Xu, Cheng Liu, Jianming Liu and Rik Derynck. Proteolysis mediated signal cross-talk in tumor microenvironment. Global COE 5th Retreat/Symposium: Integrative Life Science Biosignaling, 2012, Yamanashi, Japan. (Invited Speaker)
Pinglong Xuand Rik Derynck. Growth signaling from the inflammatory tumor microenvironment through p38 MAP kinase, TACE, and the EGF receptor. FASEB Receptor Tyrosine Kinase: Biology and Cancer, 2010, Carefree, Arizona.
Pinglong Xu, Chen Liu and Rik Derynck. Roles of TACE-mediated ectodomain shedding in signaling cross-talk and cancer cell behavior. FASEB Protein Kinases and Protein Phosphorylation. 2009, Snowmass, Colorado.
Pinglong Xuand Rik Derynck. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. UCSF Biomedical Science Program Retreat. 2008, Lake Tahoe, California.