韩守法，Ph.D.
教授，博士生导师
课题组组长
电话：
Email：shoufa@xmu.edu.cn

教育及工作经历：
北京大学化学系, 获学士学位(1996)
中国科学院北京化学研究所, 获得高分子化学与物理专业硕士学位（1999）
Toledo大学, 获得生物化学专业博士（2003）
The Scripps Research Institute博士后（2003-2006）
厦门大学化学生物学系教授，博导（2006-今）
研究领域：
1. 化学生物学，研究包括糖蛋白所含的唾液酸的功能,如IgG；
2. 化学或酶催化法引入非天然唾液酸到蛋白上改善其生物活性；
3. 酶催化法合成含有唾液酸的小分子或纳米材料探针把小分子药物或蛋白质运载到特定的细胞内。
代表性论文：
1. A self-referenced nanodosimeter for reaction based ratiometric detection of hypochlorous acid in living cells，Chemical Science, 2013, 460-467; Xuanjun Wu, Zhu Li, Yuhui Yang, Liu Yang, Jiahuai Han and Shoufa Han*
2. Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)] as lysosome activatable probes for intraoperative detection of tumors，Chemical Science, 2012, 2941-2948; Zhu Li, Yunlong Song, Yuhui Yang, Liu Yang, Jiahuai Han and Shoufa Han*
3. Cytosolic delivey of proteins mediated by aldehyde-displaying silica nanoparticles with pH responsive characteristics, Journal of Materials Chemistry, 2012, 17121-17127; Xuanjun Wu, Shuqi Wu, Jiahuai Han and Shoufa Han*
4. Fluorogenic detection of hydrogen sulfide via reductive unmasking of o-azidomethylbenzoyl-coumarin conjugate, Chemical Communication, 2012, 48, 10120-10122; Zhisheng Wu, Zhu Li, Liu Yang, Jiahuai Han and Shoufa Han*
5. Covalent labeling of Mitochondria with a photostable fluorescent thiol-reactive rhodamine-based probe, Analytical Methods, 2012, 4, 1699-1703; Shuqi Wu, Yunlong Song, Zhu Li, Zhisheng Wu, Jiahuai Han and Shoufa Han*
6. A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent stimulant, Bioorganic and Medicinal Chemistry Letter, 2012, 6358-6361; Zhisheng Wu, Xuanjun Wu, Tingbin Wen and Shoufa Han*
7. A highly sensitive fluorogenic chemodosimeter for rapid visual detection of phosgene, Chemical Communication, 2012, 48, 1895; Xuanjun Wu, Zhisheng Wu, Yuhui Yang and Shoufa Han*
8. A selective fluorogenic sensor for visual detection of nitrite, Analytical Methods, 2012, 4, 2021-2026; Zhongwei Xue, Zhisheng Wu and Shoufa Han*
9. Dual colored mesoporous silica nanoparticles with pH activatable rhodamine-lactam for sensing of lysosomal acidity, Chemical Communication, 2011, 47, 11276, Shuqi Wu, Zhu Li, Jiahuai han, and Shoufa Han*
10. Imaging of intracellular acidic compartments with a sensitive rhodamine based fluorogenic pH sensor, Analyst, 2011, 136, 3698, Zhu Li, Shuqi Wu, J. Han and Shoufa Han*
11. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor, Chemical Communication, 2011, 47, 11468, Xuanjun Wu, Zhisheng Wu, and Shoufa Han*
12. Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor, Organic and Biomolecualr Chemistry, 2011, 9, 7652-7654, Zhu Li, Z. Xue, Jiahuai Han, and Shoufa Han*
13. Visual and fluorogenic detection of nerve agent stimulant via Lossen rearrangement of Rhodamine-hydroxamate；Chemical Communication, 2010，46, 8413；Zhongwei Xue, Zhen Wang and Ting Bin Wen, Shoufa Han*
14. Multivalent mannose-displaying nanoparticles constructed from polystyrene-co-poly- (styrene-alt-maleic anhydride); Organic and Biomolecular Chemistry. 2009, 7, 2040, Su R, Li L, Chen X, Han J, Shoufa Han*
15. Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates, Bioorganic and Medicinal Chemistry Letter, 2009, 19, 1903；Fang W, Cai Y, Chen X, Su R, Chen T, Xia N, Li L, Yang Q, Jiahuai Han *, Shoufa Han*
16. Synthesis of 9-substituted sialic acids as probes for CD22-ligand interactions on B cells；Frontiers in Modern Carbohydrate Chemistry, 2006, 2-16; Shoufa Han, Brian E. Collins and James C. Paulson,
17. High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells；Journal of Immunology, 2006, 177: 2994-3003; Brian E. Collins, Ola Blixt, Shoufa Han, Bao Duong, Nicolai Bovin, and James C. Paulson,
18. Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking；Nature Chemical Biology, 2005, 1, 93-97；Shoufa Han, Brian E. Collins, Per Bengtson, and James C. Paulson*
19. A facile synthesis of a difluoromethylene analog of aspartyl phosphate for inhibition of L-aspartate dehydrogenase；Synlett, 2003, Vol6, 845-846；Shoufa Han, Roger A. Moore, and Ronald E. Viola*
20. Synthesis and evaluation of alternative substrates for arginase；Bioorganic Chemistry, 2002, vol30, 81-94；Shoufa Han, Roger A. Moore, and Ronald E. Viola*
21. A Spectrophotometric assay of arginase；Analytical Biochemistry, 2001, 295(1), 117-119, Shoufa Hanand Ronald E. Viola*