许韧“闽江****”****、博导
厦门大学“南强青年拔尖A类人才”


学科（方向）：系统骨骼生物学与骨骼退行性疾病
邮 箱：xuren526@xmu.edu.cn








研究领域：
近年来，骨骼系统与机体其他组织/器官之间的偶联机制逐渐成为系统生物学研究的新兴热点，也是进行精准医学治疗所必须明确的核心内容。许韧博士一直聚焦于骨形成细胞与其支撑系统的交流机制，深入探究成骨微环境的调控功能和潜在的临床价值。其中以第一作者身份在Nature、Nature Medicine和JBMR等国际知名期刊上均发表研究成果。还先后获得过ICMRS-Webster Jee青年****奖（2017）、ASBMR青年****奖（2018）和AIMM-John Haddad青年****奖（2019）等国际学术奖项。目前实验室致力的主要研究方向如下：


1）骨特异性神经/血管体系在骨骼退行性疾病中的作用机制
2）成骨细胞来源细胞因子在机体能量代谢中的功能
3）骨骼干细胞/前体细胞在癌症发生和骨转移中的介导机制


学习经历：
2001~2005安徽师范大学生物技术专业 理学学士；
2005~2008厦门大学微生物药物学专业 理学硕士；
2009~2013日本国立东京医科齿科大学骨外科学专业 理学博士；


工作经历：
2013~2014日本国立东京医科齿科大学骨科外国人特别研究员；
2014~2019美国康奈尔大学威尔医学院博士后
2019.9~至今 厦门大学医学院教授


代表性成果：
Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss.Nature Medicine2018 Jun;24(6):823-833.


Fukuda T*, Takeda S*,Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations.Nature2013 May 23;497(7450):490-3. (*: Co-first author)


Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M,Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are criticalmediators of osteoblast activity in vivo.J Bone Miner Res.2017 Sep;32(9):1811-1815.


Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study.Bone Joint J.2019 Jul;101-B:108-114. (*: Co-first author)


Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T,Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing.Nature2018 Oct;562(7725):133-139.


主持过的重要课题：
SLIT3介导的血管亚型在骨骼干细胞微环境中的作用机制研究，国家自然科学基金面上项目（），2020/01-2023/12，￥550,000，主持


厦门大学“南强青年拔尖A类人才”启动经费，￥3,000,000，主持


CornellUniversity-FFPI Grant, “Identification of Novel Mediators Governing Osteoblast-Type H Endothelial Cells Coupling”, 2015-2017，$100,000，主持.


已申请的专利：
美国专利：Matthew Greenblatt,Ren Xuand Laurie Glimcher, SLIT and Bone Growth Modulation (Filing, US 62/630,557) 2018


所有论文列表(*:共同第一作者,^#:通讯作者)
1: Li N,InoueK, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B,Xu R^#, Greenblatt MB.Osteoclasts Are Not a Source of SLIT3.Bone Res.2019 (Accepted,厦门大学第一单位).
2: Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study.Bone Joint J. 2019 Jul;101-B:108-114. (厦门大学第一单位)
3:Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss.Nature Medicine2018 Jun;24(6):823-833.
4: Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T,Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing.Nature2018 Oct;562(7725):133-139.
5: Inoue K, Deng Z, Chen Y, Giannopoulou E,Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG, Sood AK, Zhao L, Zhao B. Bone protection by inhibition of microRNA-182.Nat Commun.2018 Oct 5;9(1):4108.
6: Ji G, Han A, Hao X, Li N,Xu R, Wang F. Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique foranterior cruciate ligament reconstruction: a systematic review of comparativetrials.Arch Orthop Trauma Surg.2018 Nov;138(11):1575-1581.
7:Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M,Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are criticalmediators of osteoblast activity in vivo.J Bone Miner Res.2017 Sep;32(9):1811-1815.
8: Ma C, Fukuda T, Ochi H, Sunamura S, Xu C,Xu R, Okawa A, Takeda S. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.Mol Metab.2015 Jan 21;4(3):175-85.
9:Xu R^#. Semaphorin 3A: A new player in bone remodeling.Cell Adh Migr.2014;8(1):5-10. Review.
10: Fukuda T*, Takeda S*,Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations.Nature2013 May 23;497(7450):490-3.
11: Wang M, Liu S, Li Y,Xu R, Lu C, Shen Y. Protoplast mutation and genome shuffling induce the endophytic fungusTubercularia sp.TF5 to produce new compounds.Curr Microbiol.2010 Oct;61(4):254-60. (厦门大学第一单位)
12: Inose H, Ochi H, Kimura A, Fujita K,Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K,Takeda S. A microRNA regulatory mechanism of osteoblast differentiation.Proc Natl Acad Sci U S A.2009 Dec 8;106(49):20794-9.
13:Xu R, Wang M, Lu C, Shen Y. Tuberculariol A – C, new sesquiterpenes from mutant-741 ofTubercularia sp.TF5.Helv Chim Acta.2009;92:1514-19. (厦门大学第一单位)
14:Xu R, Lu C, Wu X, Lin C and Zheng Z. A new ten-membered lactone fromTubercularia sp. TF5, an endophytic fungus ofTaxus mairei.Chem. Nat. Compd.2009;45; 6. (厦门大学第一单位)