朱永群
浙江大学生命科学研究院, 教授、博士生导师
国家自然科学基金委优秀青年科学基金获得者
浙江省****科学基金获得者
杭州市余杭塘路866号浙江大学医学院科研楼A201, 邮编：310058
邮箱：zhuyongqun@zju.edu.cn
电话：


教育与工作背景
2012年-至今浙江大学生命科学研究院教授，博士生导师
2010年-2012年美国霍华德-休斯医学研究所/斯隆-凯特琳癌症研究中心研究员
2007年-2010年北京生命科学研究所博士后
2002年-2007年中国科学院生物物理研究所生物化学与分子生物学博士
1998年-2002年南开大学生物物理学学士
代表性研究论文:
1. Jin-Gen Xu, Chunfeng Huang, Zhengfeng Yang, Mengmeng Jin, Panhan Fu, Ni Zhang, Jian Luo, Dali Li, Mingyao Liu, Yan Zhou and Yongqun Zhu. Crystal Structure of LGR4-Rspo1 complex: Insights into the Divergent Mechanisms of Ligand Recognition by LGR Receptors. J Biol Chem. 2014 Dec 5. [Epub ahead of print]

2. Yan Zhou and Yongqun Zhu. Diversity of bacterial manipulation of the host ubiquitin pathways. Cellular Microbiology. Epub 2014 Nov 22.

3. Panhan Fu, Xiaoqing Zhang, Mengmeng Jin, Li Xu, Chong Wang, Zongping Xia, Yongqun Zhu. Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition. PLOS Pathogens. 2013 Apr.

4. Na Dong*, Yongqun Zhu*#, Qiuhe Lu, Liyan Hu, Yuqing Zheng, Feng Shao#.Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell. 2012 Aug 31;150(5):1029-41. (* equal contribution, #共同通讯作者)

5. Yongqun Zhu, Hongtao Li,Chengzu Long, Liyan Hu, Hao Xu, Liping Liu, She Chen, Da-Cheng Wang, and Feng Shao. Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase. Molecular Cell. 28, 899–913, Dec 14, 2007.

6. Yongqun Zhu, Hongtao Li, Jiayi Wang, Liyan Hu, Yan Zhou, Liping Liu, Feng Shao. Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nature Structural & Molecular Biology. 15(12):1302-8, Dec 2008.

7. Yongqun Zhu, Liyan Hu, Yan Zhou, Qing Yao, and Feng Shao. Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci USA. 2010 Mar 9; 107(10):4699-704.

8. Qing Yao, Jixin Cui, Yongqun Zhu, Guolun Wang, Liyan Hu, Chengzu Long, Ran Cao, Xinqi Liu, Niu Huang, She Chen, Liping Liu, and Feng Shao. A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad Sci USA. 2009 Mar 10; 106(10):3716-21.

9. Yong-QunZhu, De-Yu Zhu, Lei Yin, Ying Zhang, Clemens Vonrhein, and Da-Cheng Wang. Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily. PROTEINS. 63:1127–1131, 2006.

10. De-Yu Zhu, Yong-QunZhu*, Ren-Huai Huang, Ye Xiang, Na Yang, Hong-Xia Lu, Gen-Pei Li, Qi Jin, and Da-Cheng Wang. Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7? Resolution: The First Structure of a New Sequence Family of TIM Barrels. PROTEINS.58:764–768, 2005. (* equal contribution)

11. De-Yu Zhu, Yong-QunZhu*, Ye Xiang and Da-Cheng Wang. Optimizing Protein Crystal Growth through Dynamic Seeding. Acta Cryst D. (2005). 61, 772-775. (*equal contribution)

12. Yong-QunZhu, De-Yu Zhu, Hong-Xia Lu, Na Yang, Gen-Pei Li, Da-Cheng Wang.
Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri. Protein & Peptide Letters. 12, 823-826, 2005.