Long Zhang (Zhang L) Ph.D.
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Address (CN): Nano building Room A575, 866 Yuhangtang Road, Hangzhou, Zhejiang Province 310058 China.
Tel: (office) (lab)
E-mail: L_Zhang@zju.edu.cn.
Address (EU): Dept. Molecular Cell Biology Building 2, Room R-02-02 Leiden
University Medical Center Postzone S-1-P Postbus 9600, 2300 RC Leiden, The Netherlands.
Tel: +31-71-526 9269 (office) Fax: +31-
Email: L.zhang@lumc.nl
Doctorate Department of Biological Science and Biotechnology, Tsinghua University,China. June, 2008


Work experience since graduating
August 2008 ¨C August 2010: Post of Scientific Researcher, Leiden University
Medical Center (LUMC), The Netherland.
Sep. 2010 ¨C May 2013: Researcher, Leiden University Medical Center (LUMC),
The Netherland.
June 2013 ¨C Sep. 2013: Research Assistant Professor, Researcher, Leiden
University Medical Center (LUMC), The Netherland.
Sep. 2013 ¨C present: Research Assistant Professor (Guest), Leiden University
Medical Center (LUMC), The Netherland.
Sep. 2013 ¨C present: Professor, Life Science Institute, Zhejiang University, China
International collaborations
Collaborate internationally with
Novartis Institutes for Biomedical Research, USA.
Novartis institutes, Shanghai, China
Institute of Biology, Leiden University, The Netherland
School of Life Science, Tsinghua University, China
Chongqing medical University, China
School of Medicine, Xiamen University, China
Grants
(Joined grant) Netherlands Organization for Scientific Research (NWO
918.66.066) and Center for Biomedical Genetics. €180.000
(Joined grant) Netherlands Organization for Scientific Research (VICI
016.066.606) €845.000
(Joined grant) Centre for Biomedical Genetics on ¡°TGF-beta signal transduction
in cancer and other diseases¡± €330.000
(Joined grant) Swedish Cancer Society grant on "Targeting TGF- ¦Â in breast
cancer invasion and metastasis" €180.000
Zhejiang University Special Fund for Fundamental Research and the
Fundamental Research Funds for the Central Universities. RMB5000.000
Zhejiang Provincial Natural Science Foundation of China (Grant No.
R14C070002). RMB360.000
The National Natural Science Funds of China (Grant No. **). RMB
1000.000
Publications and Citations:
List of Publications:
Accepted publications:
(1) Regulation of TGF-¦Â Superfamily Signaling by SMAD Mono-Ubiquitination.
Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. Cells. 2014 Oct 15;3(4):981-93.
doi: 10.3390/cells**. Review. (#corresponding author)
(2) TRAF4 mediates activation of TGF-¦Â signaling and is a biomarker for
oncogenesis in breast cancer.Zhou F, Li F, Xie F, Zhang Z, Huang H, Zhang L#.
Sci China Life Sci. 2014 Sep 24. (#corresponding author)
(3) Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. The
regulation of TGF-¦Â/SMAD signaling by protein deubiquitination. Protein
Cell. 2014 Apr 23 (#corresponding author)
(4) Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by
activating TGF-b signaling. Zhou F, Drabsch Y, Dekker T, Vinuesa A, Li Y,
Hawinkels L, Sheppard K-A, Goumans M-J, Luwor R.B, Carlie J, Wilma E,
Tollenaar R.A, Devilee P, Chris X, Zhu HJ, Zhang L# & Ten Dijke P#. Nat
Commun. 2014 (#corresponding author)
(5) Zhang L#, Zhou F Ten Dijke P. Signaling interplay between TGF-¦Â receptor
and PI3K/AKT pathway in cancer. Trends Biochem Sci. 38(12), pp.612-20,
2013 (#corresponding author)
(6) Zhang L, Zhou F*, Garc¨ªa de Vinuesa A, de Kruijf EM, Mesker WE, Hui L,
Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ,
Lu CX, Ten Dijke P*. TRAF4 Promotes TGF-¦Â Receptor Signaling and Drives
Breast Cancer Metastasis. Mol Cell. 51(5), pp. 559-72, 2013
(7) Drabsch Y, He S, Zhang L, Snaar-Jagalska BE1, Ten Dijke P.
Transforming growth factor-
¦Âsignalling controls human breast cancer metastasis in
a zebrafish xenograft model. Breast Cancer Res. 15(6), pp. R106, 2013
(8) Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, and ten Dijke P*.
Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated
monoubiquitination of SMAD6. EMBO J. 32(7), pp. 996-1007, 2013
(9) Zhang X, Zhang J, Zhang L, van Dam H, Ten Dijke P*. UBE2O negatively
regulates TRAF6-mediated NF-¦ÊB activation by inhibiting TRAF6
polyubiquitination. Cell Res. 23(3), pp. 366-77, 2013
(10) Zhang L, Zhou F, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H,
Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation
and directly deubiquitinates TGF-¦Â type I receptor. Nat Cell Biol. 14(7), pp. 717-
26, 2012
(11) Zhang L#, Huang H, Zhou F, Pardo CG, Zhang T, Barakat TS, Sheppard KA,
van Dam H, Gribnau J, Lu C, and ten Dijke P#. RNF12 controls embryonic stem
cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for
degradation. Mol Cell. 46(5), pp. 650-61, 2012 (#corresponding author)
(12) Zhou F, Kai Gong, Yandao Gong and Zhang L#. APP intracellular domain
(AICD) inhibits Wnt signaling and promotes neurite outgrowth. Biochim Biophys
Acta-Molecular Cell Research. 1823(8), pp. 1233-41, 2012 (#corresponding
author)
(13) Zhang, J, Zhang X-f, Zhang L, Zhou F, van Dinther M, ten Dijke P. LRP8
mediates Wnt/¦Â-catenin signaling and controls osteoblast differentiation. J Bone
Miner Res. 27(10), pp. 2065-74, 2012
(14) Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P. Fasassociated
factor 1 is a scaffold protein that promotes ¦Â-TrCP mediated ¦Â-catenin
ubiquitination and degradation. J Biol Chem. 287(36), pp. 30701-10, 2012
(15) Gong K, Zhou F, Huang HZ, Gong YD, Zhang L#. Suppression of GSK3¦Â
by ERK mediates lipopolysaccharide induced cell migration in macrophage
through ¦Â-catenin signaling. Protein Cell. 3(10), pp. 762-8, 2012 (#corresponding
author)
(16) Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ, Zhang L#. Ubiquitinspecific
protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and
regulates innate immune activation. J Biol Chem. 287(14), pp. 11002-10, 2012
(#corresponding author)
(17) Zhang L, Shi S, Zhang J, Zhou F, ten Dijke P. Wnt/¦Â-catenin signaling
changes C2C12 myoblast proliferation and differentiation by inducing Id3
expression. Biochem Biophys Res Commun. 419(1), pp. 83-8, 2012
(18) Zhou F, Huang H, Zhang L# Bisindoylmaleimide I enhances osteogenic
differentiation. Protein Cell. 3(4), pp. 311-20, 2012 (#corresponding author)
(19) Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, Abdalla FC, Abeliovich H, et al, Zhang Let al. Autophagy. 8(4), pp.
445-544, 2012
(20) Zhou F# , Zhang L#, van Laar T, van Dam H, ten Dijke P*. GSK3¦Â
inactivation induces apoptosis of leukemia cells by repressing the function of c-
Myb. Mol Biol Cell. 22(18), pp. 3533-40, 2011 (#o-first authors)
(21) Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, ten Dijke P. Fasassociated
factor 1 antagonizes Wnt signaling by promoting ¦Â-
catenin degradation. Mol Biol Cell. 22(9), pp. 1617-24, 2011
(22) Zhou F, van Laar T, Huang HZ, Zhang L#. APP and APLP1 are degradated
through autophagy in response to proteasome inhibition in neuronal cells.
Protein Cell. 2(5), pp. 377-83, 2011 (#corresponding author)
(23) Zhou F; Gong K; van Laar T; Gong Y, Zhang L#. Wnt/¦Â-catenin signal
pathway stabilizes APP intracellular domain (AICD) and promotes its
transcriptional activity. Biochem Biophys Res Commun. 412(1), pp. 68-73,
2011 (#corresponding author)
(24) Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y,
Chen YG*. TSC-22 promotes TGF-¦Â-mediated cardiac myofibroblast
differentiation by antagonizing Smad7 activity. Mol Cell Biol. 31(18), pp. 3700-9,
2011
(25) Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima
M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W*. Follistatin-like 1
(Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in
controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17), pp.
7058-63, 2011
(26) Zhou F#, Zhang L#, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X,
Gong Y*. LEF-1 activates the transcription of E2F1. Biochem Biophys Res
Commun. 365(1), pp. 149-53, 2008 (#co-first authors)
(27) Zhou F#, Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X,
Zhao N, Gong Y*. The association of GSK3¦Â with E2F1 facilitates nerve growth
factor-induced neural cell differentiation. J Biol Chem. 283(21), pp. 14506-15,
2008 (#co-first authors)
(28) Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG*. Dapper1 is a
nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in
the nucleus. J Biol Chem. 283(51), pp. 35679-88, 2008
(29) Su Y#, Zhang L#, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG*. The
evolutionally conserved activity of Dapper2 in antagonizing TGF-¦Â signaling.
FASEB J. 21(3), pp. 682-90, 2007 (#co-first authors)
(29) Chen YG*, Wang Z, Ma J, Zhang L, Lu Z. Endofin, a FYVE domain protein,
interacts with Smad4 and facilitates transforming growth factor-¦Â signaling. J Biol
Chem. 282(13), pp. 9688-95, 2007
(30) Zhang L, Gao X, Wen J, Ning Y, Chen YG*. Dapper 1 antagonizes Wnt
signaling by promoting dishevelled degradation. J Biol Chem. 281(13), pp. 8607-
12, 2006
(31) Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG*.
Functional analysis of mutations in the kinase domain of the TGF-¦Â receptor
ALK1 reveals different mechanisms for induction of hereditary hemorrhagic
telangiectasia. Blood. 107(5), pp. 1951-4, 2006
(32) Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen
YG, Meng A*. Zebrafish Dpr2 inhibits mesoderm induction by promoting
degradation of nodal receptors. Science. ;306(5693)pp. 114-7, 2004
Meeting Abstract:
(33)Long Zhang, Suping Zhang, Xia Gao, Jun Wen, Yeguang Chen. Modulation
of TGF-signaling in the cytoplasm and the nucleus. The 5th Asian-Pacific
Organization for Cell Biology Congress (APOCB 2006), Oct. 28 to 31, 2006,
Beijing , China. Published in Cell Research (2006) 16:S131-S157 (APOCB2006-
09-052, page S153)