肖能明Nengming Xiao, Professor
Huang-Chao Yang Building F116,
School of Life Sciences, Xiamen University,
Xiang’an District, Xiamen, Fujian 361102, China
Tel: +86- (O), 86-** (M)
Email: nengming@xmu.edu.cn


Education
9/2000-1/2006, Ph.D. in Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Peking University
9/1995-7/2000, B.S. in Biochemistry, Department of Biochemistry and Molecular Biology, College of Life Sciences, Beijing Normal University
Professional Experiences
12/2014-Present, Professor, School of Life Sciences, Xiamen University, Xiamen, China
6/2010-9/2014, Postdoctoral Fellow, Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
5/2009-5/2010, Postdoctoral Fellow, Department of Immunology, Lerner Research Institute，Cleveland Clinic, Ohio, USA
8/2006-4/2009, Research Associate, Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
Publications
1)Chen R, Bélanger S, Frederick MA, Li B, Johnston RJ, Xiao N, Liu YC, Sharma S, Peters B, Rao A, Crotty S, Pipkin ME. In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation. Immunity. 2014 Aug 21;41(2):325-38.
2)Sabouri AH, Marcondes MC, Flynn C, Berger M, Xiao N, Fox HS, Sarvetnick NE. TLR signaling controls lethal encephalitis in WNV-infected brain. Brain Res. 2014 Jul 29;1574:84-95.
3)Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu YC. The E3 ubiquitin ligase Itch is required for the differentiation of T follicular helper cells. Nat Immunol. 2014 Jul;15(7):657-66.
4)Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Harding CV, Hise AG, Hazen SL, Defranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med.?2014 May 5; 211(5):887-907.?
5)Burkart C, Arimoto KI, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies LG, Zhang DE. Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10. EMBO Mol Med.??2013 Jul;5(7):967-82.
6)Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Tomisato W, Webster V, Won S, Xia Y, Xiao N, Beutler B. ENU-induced phenovariance in mice: inferences from 587 mutations. BMC Res Notes. 2012 Oct 24;5(1):577.
7)Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, Li X. β-TrCP-Mediated IRAK1 Degradation Releases TAK1-TRAF6 from the Membrane to the Cytosol for TAK1-Dependent NF-κB Activation. Mol Cell Biol. 2012 Oct;32(19):3990-4000.
8)Siggs OM*, Xiao N*, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B. iRhom2 is required for the secretion of mouse TNFα. Blood. 2012 Jun 14;119(24):5769-71. (*Co-first author).
9)Xiao N, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B. The Tpl2 mutation sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 2009 Dec 15;183(12):7975-83.
10)Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS One. 2009 Oct 22;4(10):e7411.
11)Brandl K, Rutschmann S, Li X, Du X, Xiao N, Schnabl B, Brenner DA, Beutler B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3300-5.
12)Xu L*, Xiao N*, Liu F, Ren H, Gu J. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1530-5. (*Co-first author).
13)Xiao NM, Zhang YM, Zheng Q, Gu J. (2004). Klotho is a serum factor related to human aging. Chinese Medical Journal. 117(5): 742-747.
Conference Presentations
Xiao N, Eto D, Elly C, Crotty S, Liu YC. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Oral presentation in 39th Annual La Jolla Immunology Conference, La Jolla, California, USA, October 8-10, 2013.
Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu YC. The E3 ubiquitin ligase Itch is required for the differentiation of T follicular helper cells. Oral presentation in 4th China Tregs/Th Subsets 2014 Conference, Shanghai, China, November 1-4, 2014.