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摘要磁感应热疗在临床实施时,需要达到适形杀灭肿瘤和保护正常组织的治疗目标,因此要求在术前治疗计划系统中对靶区的温度分布情况进行数值模拟,以指导医生制定合适的治疗计划,确保治疗的安全性和有效性。该文基于VTK/ITK等医学影像开源算法工具包,采用医学CT影像3维重建数据场信息,对磁感应热疗过程中治疗区域内的肿瘤及其周围组织进行可视化和适形分割,以确立治疗靶区和植入热籽; 基于电磁学和生物传热学的理论方法,以及肿瘤内的适形热籽排布方案,对治疗时热籽磁热效应产生的能量场分布和热量扩散形成的温度场分布进行理论建模和仿真; 并将适形热疗方法实际应用于肿瘤磁感应热疗计划系统中。结果表明: 磁感应治疗计划系统的适形热疗方法可以辅助医生直观地分割肿瘤和组织器官,进而准确计算靶区的温度场分布,制定合理的适形热疗计划。
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| 关键词 ：肿瘤热疗,磁感应治疗,术前计划,建模仿真 |
Abstract：Clinical implementation of magnetic induction hyperthermia (MIH) seeks to conformally killing tumor cells while protecting the normal tissue. Thus, the temperature distribution in the treatment area needs to be accurately simulated by the preoperative treatment planning systems (TPS) to help the surgeon make an appropriate clinical plan to ensure the safety and efficacy of the MIH therapy. Medical image open source toolkits, such as VTK and ITK, can give accurate 3-D reconstruction, visualization and segmentation of tumors and their surrounding tissue from 2-D CT images. Then, ferromagnetic thermoseeds are implanted into the tumor region. Electromagnetism and bio-heat transfer theories are used to predict the energy fields generated by the thermoseeds and the temperature distributions due to the heat diffusion in the MIH process. This conformal-hyperthermia method can be applied in magnetic induction hyperthermia treatment planning systems (MHTPS). The results show that the conformal-hyperthermia method in MHTPS can help surgeons intuitively segment tumors, accurately predict the temperature distributions in the treatment area, and make reasonable preoperative plans.
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| Key words：tumor hyperthermiamagnetic induction therapypreoperative planningmodeling and simulation |
| 收稿日期: 2012-10-18 出版日期: 2015-03-17 |
| 基金资助:国家科技支撑计划资助项目 (2012BAI15B04);北京市科技计划资助项目 (Z111100067311053) |
| [1] | 曾益新. 磁感应热疗技术为中国创造新的希望和契机[J]. 科技导报, 2010, 28(19): 3. ZENG Yixin. The technique of magnetic induction hyperthermia: A hope and opportunity for innovative meditech in China[J]. Science & Technology Review, 2010, 28(19): 3. (in Chinese) |
| [2] | 王宇瀛, 赵凌云, 王晓文, 等. 磁感应热疗治疗肿瘤研究进展和临床试验[J]. 科技导报, 2010, 28(20): 101-107. WANG Yuying, ZHAO Lingyun, WANG Xiaowen, et al.Research progress and clinical trials of magnetic induction hyperthermia for cancer treatment[J]. Science & Technology Review, 2010, 28(20): 101-107. (in Chinese) |
| [3] | 王捷忠, 潘建基, 张春, 等. 关于磁感应热疗技术治疗软组织肿瘤近期疗效和安全性的临床报告[J]. 福建医科大学学报, 2012, 46(1): 47-50. WANG Jiezhong, PAN Jianji, ZHANG Chun, et al.A clinical report on effectiveness and safety of magnetic induction thermotherapy for soft tissue tumor[J]. Journal of Fujian Medical University, 2012, 46(1): 47-50. (in Chinese) |
| [4] | 唐劲天. 肿瘤热疗生物学[M]. 北京: 人民卫生出版社, 2010. TANG Jintian. Tumor Hyperthermia Biology[M]. Beijing: People's Medical Publishing House, 2010. (in Chinese) |
| [5] | 杨雄伟. 肿瘤磁介导加温治疗计划系统相关研究与实现[D]. 广州: 广东工业大学, 2007. YANG Xiongwei. Magnetic Interstitial Tumor Hyperthermia Planning System Correlation Study and Implementation [D]. Guangzhou: Guangdong Industry University, 2007. (in Chinese) |
| [6] | Chin R B, Stauffer P R. Treatment planning for ferromagnetic seed heating[J]. International Journal of Radiation Oncology* Biology* Physics, 1991, 21(2): 431-439. |
| [7] | Zhuo Z H, Zhai W M, Cai D Y, et al.Design and implementation of magnetic induction hyperthermia treatment planning workflow based on CT images [C]// 2013 ICME International Conference on Complex Medical Engineering. Beijing: IEEE, 2013: 40-44. |
| [8] | The Visualization Toolkit[EB/OL]. [2012-03-01]. http://www.vtk.org. |
| [9] | Insight Segmentation and Registration Toolkit[EB/OL]. [2012-03-01]. http://www.itk.org. |
| [10] | Max N. Optical models for direct volume rendering[J]. IEEE Transactions on Visualization and Computer Graphics, 1995, 1(2): 99-108. |
| [11] | Lorensen W E, Cline H E. Marching cubes: A high resolution 3D surface construction algorithm[J].ACM Siggraph Computer Graphics, 1987, 21(4): 163-169. |
| [12] | Galloway J R L. The process and development of image guided procedures[J].Annual Review of Biomedical Engineering, 2001, 3(1): 83-108. |
| [13] | Gao Y, Tannenbaum A, Kikinis R, et al.Simultaneous multi-object segmentation using local robust statistics and contour interaction [C]// International Conference on Medical Computer Vision. Beijing: Springer, 2011: 195-203. |
| [14] | 刘玲玲, 康晓东, 王昊, 等. 基于稳健特征统计的医学影像分割方法[J]. 计算机工程, 2013, 39(5): 257-260. LIU Lingling, KANG Xiaodong, WANG Hao, et al.Medical image segmentation algorithm based on robust feature statistics[J]. Computer Engineering, 2013, 39(5): 257-260. (in Chinese) |
| [15] | Haider S A, Wait J R, Cetas T C, et al.Power absorption in ferromagnetic implants from radio frequency magnetic fields and the problem of optimization[J]. IEEE Transactions on Microwave Theory and Techniques, 1991, 39(11): 1817-1827. |
| [16] | Chen Z P. Three-dimensional simulations of ferromagnetic implant hyperthermia[J]. Medical Physics, 1992, 19(4): 989-997. |
| [17] | Pennes H H. Analysis of tissue and arterial blood temperature in the resting forearm[J].Journal of Applied Physiology, 1948, 1(2): 93-122. |
| [18] | 刘静, 邓中山. 肿瘤热疗物理学 [M]. 北京: 科学出版社, 2008: 34-37. LIU Jing, DENG Zhongshan. Physics of Tumor Hyperthermia [M]. Beijing: Science Press, 2008: 34-37. (in Chinese) |
| [19] | 李人宪. 有限体积法基础 [M]. 2版. 北京: 国防工业出版社, 2008: 15-35. LI Renxian. Basis of Finite Volume Method [M]. 2nd Ed. Beijing: National Defense Industry Press, 2008: 15-35. (in Chinese) |
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