段宇婧¹,
吴新颜¹,
陈则友¹,
陈颖^1,4,
李林云¹,
祝思源¹,
毛大庆³,
罗义^1,2,,
1. 南开大学环境科学与工程学院, 环境污染过程与基准教育部重点实验室, 天津 300350;
2. 南京大学环境学院, 污染控制与资源化国家重点实验室, 南京 210093;
3. 南开大学医学院, 天津 300071;
4. 辽宁大学环境学院, 沈阳 110036

作者简介: 段宇婧(1990-),女,博士研究生,研究方向为微生物耐药基因,E-mail:cathydyj@126.com.

通讯作者: 罗义,luoy@nankai.edu.cn

基金项目: 国家自然科学基金重点资助项目（41831287）；国家****科学基金资助项目（41525013）；国家自然科学基金资助项目（31670509，41977367，31870351，41807483）；天津市自然科学基金资助项目（19JCZDJC40800）


中图分类号: X171.5

Advances in Human Gut Resistome

Duan Yujing¹,
Wu Xinyan¹,
Chen Zeyou¹,
Chen Ying^1,4,
Li Linyun¹,
Zhu Siyuan¹,
Mao Daqing³,
Luo Yi^1,2,,
1. Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China;
2. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China;
3. School of Medicine, Nankai University, Tianjin 300071, China;
4. College of Environment, Liaoning University, Shenyang 110036, China

Corresponding author: Luo Yi,luoy@nankai.edu.cn

CLC number: X171.5

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摘要:人类肠道菌群是耐药基因（antibiotic resistance genes，ARGs）的"储存库"，且与人体健康密切相关。目前，抗生素的滥用严重，进一步加剧了耐药基因的传播和扩散。细菌耐药问题严重影响人体健康、食品安全和生态安全，携带耐药基因的致病菌对临床治疗造成巨大威胁。本文结合国内外研究进展，在总结人体肠道耐药基因组研究方法的基础上，探讨了肠道耐药基因的组成、来源、传播和进化，并对未来研究进行了展望，旨在促进公众对肠道耐药基因的认知，并为抗生素的合理使用提供理论支持。
关键词: 抗生素/
耐药基因/
肠道菌群/
水平基因转移

Abstract:Human gut microbiota is the reservoir of antibiotic resistance genes (ARGs) and it plays an important role to human health. The abuse of antibiotics is still severe at present, which further aggravates the spread of ARGs. Bacterial resistance seriously affects human health, food safety and ecological safety, and pathogens carrying ARGs pose a great threat to clinical treatment. In combination with the research progress in China and abroad, this paper discussed in detail about gut resistome from the aspects including the composition, origin, propagation and evolution. In addition, the research methods of human gut resistome and the future prospect were summarized. This study could promote the public’s understanding of gut resistome and provide theoretical support for rational use of antibiotics.
Key words:antibiotics/
antibiotic resistance genes/
gut microbiota/
horizontal gene transfer.

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