李厚禹1,
李晓晨2,
徐艳1,,,
郑向群1
1. 农业农村部环境保护科研监测所, 天津 300191;
2. 山东农业大学, 泰安 271018
作者简介: 邵振鲁(1995-),男,学士,研究方向为水环境污染防治,E-mail:1982635855@qq.com.
通讯作者: 徐艳,xuyan@aepi.org.cn ;
基金项目: 国家重点研发计划资助项目（2018YFC1901004）中图分类号: X171.5
The Occurrence and Risk Management of Antibiotics and Antibiotic Resistant Genes in Rural Solid Waste
Shao Zhenlu1,2,Li Houyu1,
Li Xiaochen2,
Xu Yan1,,,
Zheng Xiangqun1
1. Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China;
2. Shandong Agricultural University, Taian 271018, China
Corresponding author: Xu Yan,xuyan@aepi.org.cn ;
CLC number: X171.5
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摘要:全球范围内抗生素抗性的传播扩散严重威胁人类健康。固体废弃物中的生活垃圾、污泥和畜禽粪便是抗生素及耐药基因的重要储库。针对新型环境污染物抗生素和耐药基因，综述了农村固废中抗生素及耐药基因的赋存和传播扩散，阐述了农村固废中抗生素及细菌耐药的生态风险、控制管理和消除方法，并结合目前抗生素及耐药基因的污染状况，对今后研究重点进行了展望。
关键词: 抗生素/
耐药基因/
风险评价/
传播途径
Abstract:The spread of antibiotic resistance poses a serious threat to human health on a global scale. Domestic garbage, sludge and animal manure in solid wastes are important reservoirs for antibiotics and antibiotic resistance genes (ARGs). In view of new environmental pollutants (antibiotics and ARGs), the occurrence and dissemination of antibiotics and ARGs in rural solid waste are reviewed. The ecological risk, control management and elimination methods of antibiotics and bacterial resistance in rural solid waste are expounded. Combined with the current pollution situation of antibiotics and ARGs, the future research focus is prospected.
Key words:antibiotic/
ARGs/
risk assessment/
route of dissemination.
| 史密伟, 朱晓磊, 唐文忠. 抗生素抗性基因环境效应的研究进展[J]. 环境保护科学, 2015, 41(6):123-128Shi M W, Zhu X L, Tang W Z. Progress in research of the environmental effects of antibiotic resistance genes[J]. Environmental Protection Science, 2015, 41(6):123-128(in Chinese) |
| Van Boeckel T P, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010:An analysis of Cross Mark 742 national pharmaceutical sales data[J]. Lancet Infectious Diseases, 2014, 14(8):742-750 |
| Berglund B. Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics[J]. Infection Ecology & Epidemiology, 2015, 5:28564 |
| 崔海艳, 李秀波. 滥用抗生素对养猪业的危害及应对措施[J]. 吉林畜牧兽医, 2018, 39(10):14-16 |
| 武冬. 城市固体废弃物卫生填埋处理体系中抗生素抗性基因传播机理与控制研究[D]. 上海:华东师范大学, 2018:3-100 Wu D. Study on the dissemination of antibiotic resistance genes in a municipal solid waste landfill system and its control[D]. Shanghai:East China Normal University, 2018:3-100(in Chinese) |
| 宫国栋. 云南省禄劝县养殖户抗生素使用现状及影响因素研究[D]. 昆明:昆明医科大学, 2016:1-45 Gong G D. A survey on the utilization of antibiotics by farmers and the associated factors in Luquan County, Yunnan Province[D]. Kunming:Kunming Medical University, 2016:1-45(in Chinese) |
| 吴丹. 北京地区禽场粪便中抗生素及抗性基因污染特性与好氧堆肥实验研究[D]. 北京:北京化工大学, 2015:1-58 Wu D. Contamination characteristics and aerobic compost study of antibiotics and resistance genes in poultry manure of Beijing area[D]. Beijing:Beijing University of Chemical Technology, 2015:1-58(in Chinese) |
| Sharma V K, Johnson N, Cizmas L, et al. A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes[J]. Chemosphere, 2016, 150:702-714 |
| Lee J, Shin S G, Jang H M, et al. Characterization of antibiotic resistance genes in representative organic solid wastes:Food waste-recycling wastewater, manure, and sewage sludge[J]. Science of the Total Environment, 2017, 579:1692-1698 |
| 杨雪梅. 农村有机固体废弃物高效产沼技术研究[D]. 南京:东南大学, 2016:1-40 Yang X M. Research on efficient technology of biogas production by organic solid wastes in rural area[D]. Nanjing:Southeast University, 2016:1-40(in Chinese) |
| 孙金昭. 城市生活垃圾填埋场中抗生素残留浓度特征及抗性基因相关性研究[D]. 上海:华东师范大学, 2017:1-60 Sun J Z. Characteristics of antibiotics contents in municipal solid waste landfills and correlation with antibiotic resistance genes[D]. Shanghai:East China Normal University, 2017:1-60(in Chinese) |
| Musson S E, Townsend T, Seaburg K, et al. A continuous collection system pharmaceutical wastes:A pilot for household project[J]. Journal of the Air & Waste Management Association, 2007, 57(7):828-835 |
| Bound J P, Voulvoulis N. Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United Kingdom[J]. Environmental Health Perspectives, 2005, 113(12):1705-1711 |
| 王国兰, 冯金露, 罗玲, 等. 污水处理厂中四环素和磺胺类抗生素抗性基因的分布、传播及去除[J]. 应用生态学报, 2019(8):2875-2882 Wang G L, Feng J L, Luo L, et al. Distribution, diffuse and removal of tetracyclines and sulfonamide antibiotic resistance genes in wastewater treatment plant:A review[J]. Chinese Journal of Applied Ecology, 2019(8):2875-2882(in Chinese) |
| 张俊亚, 魏源送, 陈梅雪, 等. 畜禽粪便生物处理与土地利用全过程中抗生素和重金属抗性基因的赋存与转归特征研究进展[J]. 环境科学学报, 2015, 35(4):935-946Zhang J Y, Wei Y S, Chen M X, et al. Occurrence and fate of antibiotic and heavy metal resistance genes in the total process of biological treatment and land application of animal manure:A review[J]. Acta Scientiae Circumstantiae, 2015, 35(4):935-946(in Chinese) |
| 杨德利, 吴天强, 高健, 等. 农村固体废弃物处理现状与对策[J]. 绿色科技, 2018(24):1-4 Yang D L, Wu T Q, Gao J, et al. Analysis on the status quo and countermeasures of rural solid waste treatment in China[J]. Journal of Green Science and Technology, 2018(24):1-4(in Chinese) |
| 邹敦强, 毛正荣, 胡玉英, 等. 农村有机固体废弃物资源化利用与农村沼气工程[J]. 能源与环境, 2010(3):49-50,57 |
| Song L Y, Li L, Yang S, et al. Sulfamethoxazole, tetracycline and oxytetracycline and related antibiotic resistance genes in a large-scale landfill, China[J]. Science of the Total Environment, 2016, 551:9-15 |
| Sui Q, Zhao W T, Cao X Q, et al. Pharmaceuticals and personal care products in the leachates from a typical landfill reservoir of municipal solid waste in Shanghai, China:Occurrence and removal by a full-scale membrane bioreactor[J]. Journal of Hazardous Materials, 2017, 323:99-108 |
| Wu D, Huang Z T, Yang K, et al. Relationships between antibiotics and antibiotic resistance gene levels in municipal solid waste leachates in Shanghai, China[J]. Environmental Science & Technology, 2015, 49(7):4122-4128 |
| Wang Y Q, Tang W, Qiao J, et al. Occurrence and prevalence of antibiotic resistance in landfill leachate[J]. Environmental Science and Pollution Research, 2015, 22(16):12525-12533 |
| Tong J, Liu J B, Zheng X, et al. Fate of antibiotic resistance bacteria and genes during enhanced anaerobic digestion of sewage sludge by microwave pretreatment[J]. Bioresource Technology, 2016, 217:37-43 |
| 王超. 污泥干化芦苇床中抗生素及相关抗性基因的去除效果与相关性研究[D]. 大连:大连理工大学, 2018:1-38 Wang C. Removal efficiency and correlation study of antibiotics and related resistance genes in sludge drying reed beds[D]. Dalian:Dalian University of Technology, 2018:1-38(in Chinese) |
| Chen Y S, Yu G, Cao Q M, et al. Occurrence and environmental implications of pharmaceuticals in Chinese municipal sewage sludge[J]. Chemosphere, 2013, 93(9):1765-1772 |
| 周佳虹. 天津市城镇污水处理厂污泥中典型抗生素的分布迁移[D]. 天津:天津大学, 2017:1-58 Zhou J H. Distribution and migration of typical antibiotics in sewage sludge of municipal wastewater treatment plants in Tianjin[D]. Tianjin:Tianjin University, 2017:1-58(in Chinese) |
| Gan X M, Yan Q, Gao X, et al. Occurrence and fate of typical antibiotics in a wastewater treatment plant in Southwest China[J]. Environmental Science, 2014, 35(5):1817-1823 |
| Zhou L J, Ying G G, Liu S, et al. Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China[J]. Science of the Total Environment, 2013, 452:365-376 |
| Zhang H H, He H Y, Chen S N, et al. Abundance of antibiotic resistance genes and their association with bacterial communities in activated sludge of wastewater treatment plants:Geographical distribution and network analysis[J]. Journal of Environmental Sciences, 2019, 82:24-38 |
| Yang Y, Li B, Ju F, et al. Exploring variation of antibiotic resistance genes in activated sludge over a four-year period through a metagenomic approach[J]. Environmental Science & Technology, 2013, 47(18):10197-10205 |
| Zhang X X, Zhang T. Occurrence, abundance, and diversity of tetracycline resistance genes in 15 sewage treatment plants across China and other global locations[J]. Environmental Science & Technology, 2011, 45(7):2598-2604 |
| Munir M, Wong K, Xagoraraki I. Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan[J]. Water Research, 2011, 45(2):681-693 |
| Rizzo L, Manaia C, Merlin C, et al. Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment:A review[J]. Science of the Total Environment, 2013, 447:345-360 |
| Li Y X, Zhang X L, Li W, et al. The residues and environmental risks of multiple veterinary antibiotics in animal faeces[J]. Environmental Monitoring and Assessment, 2013, 185(3):2211-2220 |
| Chen Y S, Zhang H B, Luo Y M, et al. Occurrence and assessment of veterinary antibiotics in swine manures:A case study in East China[J]. Chinese Science Bulletin, 2012, 57(6):606-614 |
| Pan X, Qiang Z M, Ben W W, et al. Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China[J]. Chemosphere, 2011, 84(5):695-700 |
| Zhang J, Lin H, Ma J W, et al. Compost-bulking agents reduce the reservoir of antibiotics and antibiotic resistance genes in manures by modifying bacterial microbiota[J]. Science of the Total Environment, 2019, 649:396-404 |
| 王健, 贲伟伟, 强志民, 等. 我国养猪业废弃物中四环素类、磺胺类抗生素及相关抗性基因污染研究进展[J]. 生态毒理学报, 2015, 10(5):2-10Wang J, Ben W W, Qiang Z M, et al. Contamination of tetracyclines, sulfonamides and corresponding resistance genes in the waste from Chinese pig industry[J]. Asian Journal of Ecotoxicology, 2015, 10(5):2-10(in Chinese) |
| 张锦. 畜禽粪便中抗生素及抗性基因的消减研究[D]. 杭州:浙江农林大学, 2018:1-53 Zhang J. Elimination of antibiotics and resistance genes in livestock manure[D]. Hangzhou:Zhejiang Agriculture & Forestry University, 2018:1-53(in Chinese) |
| 李蕾, 徐晶, 赵由才, 等. 垃圾填埋场抗生素抗性基因初探[J]. 环境科学, 2015, 36(5):1769-1775Li L, Xu J, Zhao Y C, et al. Investigation of antibiotic resistance genes (ARGs) in landfill[J]. Environmental Science, 2015, 36(5):1769-1775(in Chinese) |
| 张明美. 污水处理系统中抗生素抗性基因污染研究[D]. 杭州:浙江大学, 2013:1-50 Zhang M M. The pollution of antibiotic resistance genes in wastewater treatment systems[D]. Hangzhou:Zhejiang University, 2013:1-50(in Chinese) |
| 王硕, 张晶, 邵兵. 超高效液相色谱-串联质谱测定污泥中氯霉素、磺胺类、喹诺酮类、四环素类与大环内酯类抗生素[J]. 分析测试学报, 2013, 32(2):179-185Wang S, Zhang J, Shao B. Analysis of chloramphenicol, sulfonamides, fluoroquinolones, tetracyclines and macrolides in sewage sludge by ultra performance liquid chromatography-tandem mass spectrometry[J]. Journal of Instrumental Analysis, 2013, 32(2):179-185(in Chinese) |
| Ferdig M, Kaleta A, Buchberger W. Improved liquid chromatographic determination of nine currently used (fluoro)quinolones with fluorescence and mass spectrometric detection for environmental samples[J]. Journal of Separation Science, 2005, 28(13):1448-1456 |
| Auerbach E A, Seyfried E E, McMahon K D. Tetracycline resistance genes in activated sludge wastewater treatment plants[J]. Water Research, 2007, 41(5):1143-1151 |
| Zhang T, Zhang M, Zhang X X, et al. Tetracycline resistance genes and tetracycline resistant lactose-fermenting enterobacteriaceae in activated sludge of sewage treatment plants[J]. Environmental Science & Technology, 2009, 43(10):3455-3460 |
| Munir M, Xagoraraki I. Levels of antibiotic resistance genes in manure, biosolids, and fertilized soil[J]. Journal of Environmental Quality, 2011, 40(1):248-255 |
| Karci A, Balcioglu I A. Investigation of the tetracycline, sulfonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey[J]. Science of the Total Environment, 2009, 407(16):4652-4664 |
| 闫书海. 畜禽养殖废水/粪便中典型抗药基因的调查研究[D]. 杭州:浙江大学, 2013:1-38 Yan S H. Research on representative antibiotic resistance genes in livestock lagoons and manures[D]. Hangzhou:Zhejiang University, 2013:1-38(in Chinese) |
| Martinez-Carballo E, Gonzalez-Barreiro C, Scharf S, et al. Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria[J]. Environmental Pollution, 2007, 148(2):570-579 |
| 杨侠. 污泥厌氧消化系统特征参数对抗生素降解迁移的影响研究[D]. 天津:天津大学, 2018:1-57 Yang X. Effects of process parameters of anaerobic sludge digestion system on degradation and migration of antibiotics[D]. Tianjin:Tianjin University, 2018:1-57(in Chinese) |
| 乔博超, 吴楠, 杨静慧, 等. 环境中抗生素抗性基因的来源、分布及控制对策[J]. 天津农林科技, 2017(6):16-18 |
| 罗迪君. 国内抗生素的主要来源和污染特征[J]. 绿色科技, 2019(14):159-161 |
| Hu X G, Zhou Q X, Luo Y. Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China[J]. Environmental Pollution, 2010, 158(9):2992-2998 |
| Peng X Z, Ou W H, Wang C W, et al. Occurrence and ecological potential of pharmaceuticals and personal care products in groundwater and reservoirs in the vicinity of municipal landfills in China[J]. Science of the Total Environment, 2014, 490:889-898 |
| Norman A, Hansen L H, Sorensen S J. Conjugative plasmids:Vessels of the communal gene pool[J]. Philosophical Transactions of the Royal Society B-Biological Sciences, 2009, 364(1527):2275-2289 |
| Bennett P M. Plasmid encoded antibiotic resistance:Acquisition and transfer of antibiotic resistance genes in bacteria[J]. British Journal of Pharmacology, 2008, 153:347-357 |
| 安新丽, 苏建强. 活性污泥抗生素抗性基因研究进展[J]. 微生物学通报, 2019(8):1-13 An X L, Su J Q. Resistome in activated sludge:Current knowledge and future directions[J]. Microbiology China, 2019(8):1-13(in Chinese) |
| Binh C T T, Heuer H, Kaupenjohann M, et al. Piggery manure used for soil fertilization is a reservoir for transferable antibiotic resistance plasmids[J]. FEMS Microbiology Ecology, 2008, 66(1):25-37 |
| Heuer H, Schmitt H, Smalla K. Antibiotic resistance gene spread due to manure application on agricultural fields[J]. Current Opinion in Microbiology, 2011, 14(3):236-243 |
| Van den Berg M, Birnbaum L, Bosveld A T C, et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife[J]. Environmental Health Perspectives, 1998, 106(12):775-792 |
| Bosveld A T C, de Bie P A F, van den Brink N W, et al. In vitro EROD induction equivalency factors for the 10 PAHs generally monitored in risk assessment studies in The Netherlands[J]. Chemosphere, 2002, 49(1):75-83 |
| Souza S M L, de Vasconcelos E C, Dziedzic M, et al. Environmental risk assessment of antibiotics:An intensive care unit analysis[J]. Chemosphere, 2009, 77(7):962-967 |
| Halling-Sorensen B, Lutzhoft H C H, Andersen H R, et al. Environmental risk assessment of antibiotics:Comparison of mecillinam, trimethoprim and ciprofloxacin[J]. Journal of Antimicrobial Chemotherapy, 2000, 46:53-58 |
| 葛林, 孙研. 世界动物卫生组织抗生素耐药性控制策略研究[J]. 中国兽药杂志, 2018, 52(8):58-62Ge L, Sun Y. The study on the OIE's strategy and standards for controlling the risks of antimicrobial resistance[J]. Chinese Journal of Veterinary Drug, 2018, 52(8):58-62(in Chinese) |
| 中国民主促进会. 尽快出台抗生素污染控制监管制度[J]. 民主, 2017(11):22-23 |
| 应露. 加强药剂科管理促进临床抗生素的合理使用[J]. 中医药管理杂志, 2017, 21(11):94-95 |
| 赵桂祥, 刘树国, 周玉红. 安全合理用药管理在乡镇卫生院药房抗生素使用中的应用效果[J]. 世界最新医学信息文摘, 2019, 19(27):146 |
| 郑淳. 导致抗生素滥用的相关因素分析及管理对策研究[J]. 世界最新医学信息文摘, 2019, 19(69):238 |
| 秦孝峰. 医院抗生素的使用现状及管理模式探讨[J]. 中国卫生标准管理, 2018(19):100-103 Qin X F. Discussion on current situation and management mode of antibiotics in hospital[J]. China Health Standard Management, 2018(19):100-103(in Chinese) |
| 徐庆霞. 浅析当前药房抗生素合理用药管理具体措施[J]. 中西医结合心血管病杂志, 2019, 7(22):189 |
| 黄菊清. 药房抗生素合理用药管理措施分析[J]. 现代医学与健康研究, 2019, 3(3):133-134 |
| Wang N, Wang Z C, Guo X Y, et al. Management policies for control of environmental risks of veterinary antibiotics[J]. Journal of Ecology and Rural Environment, 2017, 33(7):586-591 |
| 王娜, 王昝畅, 郭欣妍, 等. 兽药抗生素环境风险控制管理政策探析[J]. 生态与农村环境学报, 2017, 33(7):586-591Wang N, Wang Z C, Guo X Y, et al. Management policies for control of environmental risks of veterinary antibiotics[J]. Journal of Ecology and Rural Environment, 2017, 33(7):586-591(in Chinese) |
| 张闻, 杨佐君, 直俊强, 等. 畜禽排泄物中抗生素残留及危害的研究[J]. 今日畜牧兽医, 2019(3):70-71 |
| 王佳宁, 徐永平, 李晓宇, 等. 畜禽粪便抗生素残留及其对环境的影响[J]. 畜牧与兽医, 2017, 49(10):140-144Wang J N, Xu Y P, Li X Y, et al. Environmental impact of livestock and poultry manures with antibiotic residues[J]. Animal Husbandry & Veterinary Medicine, 2017, 49(10):140-144(in Chinese) |
| 谢春生, 杨舒婷, 魏强, 等. 肇庆星湖抗生素污染特征分析及风险评价研究[J]. 环境与健康杂志, 2019, 36(5):427-431Xie C S, Yang S T, Wei Q, et al. Antibiotic pollution characteristics and risk assessment of Xinghu Lake in Zhaoqing[J]. Journal of Environment and Health, 2019, 36(5):427-431(in Chinese) |
| 张毓森, 叶军, 苏建强. 农田生态系统抗生素抗性研究进展与挑战[J]. 浙江大学学报, 2017, 43(6):691-699Zhang Y S, Ye J, Su J Q. Antibiotic resistance in agroecosystem:Progress and challenges[J]. Journal of Zhejiang University, 2017, 43(6):691-699(in Chinese) |
| 李湉湉. 环境健康风险评估方法第一讲:环境健康风险评估概述及其在我国应用的展望(待续)[J]. 环境与健康杂志, 2015, 32(3):266-268Li T T. Environmental health risk assessment methods, first lecture:Environmental health risk assessment overview and outlook in our application (to be continued)[J]. Journal of Environment and Health, 2015, 32(3):266-268(in Chinese) |
| Martinez J L, Coque T M, Baquero F. Prioritizing risks of antibiotic resistance genes in all metagenomes[J]. Nature Reviews Microbiology, 2015, 3(6):396 |
| 张翼, 杜艳君, 李湉湉. 环境健康风险评估方法第三讲:剂量-反应关系评估(续二)[J]. 环境与健康杂志, 2015, 32(5):450-453Zhang Y, Du Y J, Li T T. Risk assessment guidelines for environmental health session 2 dose-response assessment[J]. Journal of Environment and Health, 2015, 32(5):450-453(in Chinese) |
| 杜艳君, 莫杨, 李湉湉. 环境健康风险评估方法第四讲:暴露评估(续三)[J]. 环境与健康杂志, 2015, 32(6):556-559Du Y J, Mo Y, Li T T. Risk assessment guidelines for environmental health session 3 exposure assessment[J]. Journal of Environment and Health, 2015, 32(6):556-559(in Chinese) |
| Drewes J E, Heberer T, Reddersen K. Fate of pharmaceuticals during indirect potable reuse[J]. Water Science and Technology, 2002, 46(3):73-80 |
| Onesios K M, Bouwer E J. Biological removal of pharmaceuticals and personal care products during laboratory soil aquifer treatment simulation with different primary substrate concentrations[J]. Water Research, 2012, 46(7):2365-2375 |
| Sharma S K, Hussen M, Amy G. Soil aquifer treatment using advanced primary effluent[J]. Water Science and Technology, 2011, 64(3):640-646 |
| 罗玉, 黄斌, 金玉, 等. 污水中抗生素的处理方法研究进展[J]. 化工进展, 2014, 33(9):2471-2477Luo Y, Huang B, Jin Y, et al. Research progress in the degradation of antibiotics wastewater treatment[J]. Chemical Industry and Engineering Progress, 2014, 33(9):2471-2477(in Chinese) |
| Guo Z B, Zhou F, Zhang C Z, et al. Degradation of sulfadiazine by ultrasonic[J]. Chinese Journal of Environmental Engineering, 2012, 6(9):3143-3147 |
| Xiao R Y, Diaz-Rivera D, Weavers L K. Factors influencing pharmaceutical and personal care product degradation in aqueous solution using pulsed wave ultrasound[J]. Industrial & Engineering Chemistry Research, 2013, 52(8):2824-2831 |
| Magureanu M, Piroi D, Mandache N B, et al. Degradation of antibiotics in water by non-thermal plasma treatment[J]. Water Research, 2011, 45(11):3407-3416 |
| 张启富. 低温等离子体污水处理技术与应用实验研究[D]. 合肥:中国科学技术大学, 2018:1-54 Zhang Q F. Experimental study on low-temperature plasma technology and application in treatment of polluted wastewater application[D]. Hefei:University of Science and Technology of China, 2018:1-54(in Chinese) |
| Yang C W, Hsiao W C, Chang B V. Biodegradation of sulfonamide antibiotics in sludge[J]. Chemosphere, 2016, 150:559-565 |
| Yang S F, Lin C F, Lin A Y C, et al. Sorption and biodegradation of sulfonamide antibiotics by activated sludge:Experimental assessment using batch data obtained under aerobic conditions[J]. Water Research, 2011, 45(11):3389-3397 |
| 吴迎, 冯朋雅, 李荣, 等. 环境抗生素污染的微生物修复进展[J]. 生物工程学报, 2019, 35(11):1-18Wu Y, Feng P Y, Li R, et al. Progress in microbial remediation of environmental antibiotic contamination[J]. Chinese Journal of Biotechnology, 2019, 35(11):1-18(in Chinese) |
| Sahar E, Messalem R, Cikurel H, et al. Fate of antibiotics in activated sludge followed by ultrafiltration (CAS-UF) and in a membrane bioreactor (MBR)[J]. Water Research, 2011, 45(16):4827-4836 |
| Nie Y F, Qiang Z M, Ben W W, et al. Removal of endocrine-disrupting chemicals and conventional pollutants in a continuous-operating activated sludge process integrated with zonation for excess sludge reduction[J]. Chemosphere, 2014, 105:133-138 |
| Luo W H, Phan H V, Hai F I, et al. Effects of salinity build-up on the performance and bacterial community structure of a membrane bioreactor[J]. Bioresource Technology, 2016, 200:305-310 |
| Aslam M, Charfi A, Lesage G, et al. Membrane bioreactors for wastewater treatment:A review of mechanical cleaning by scouring agents to control membrane fouling[J]. Chemical Engineering Journal, 2017, 307:897-913 |
| Shi H L, Wang X C C, Li Q, et al. Degradation of typical antibiotics during human feces aerobic composting under different temperatures[J]. Environmental Science and Pollution Research, 2016, 23(15):15076-15087 |
| Spielmeyer A, Breier B, Groissmeier K, et al. Elimination patterns of worldwide used sulfonamides and tetracyclines during anaerobic fermentation[J]. Bioresource Technology, 2015, 193:307-314 |
