中国科学院心理研究所心理健康重点实验室, 北京 100101
中国科学院大学心理学系, 北京 100049
收稿日期:2020-11-17出版日期:2022-01-15发布日期:2021-11-25通讯作者:张昆林, E-mail: zhangkl@psych.ac.cnThe mechanisms of histone modification in post-traumatic stress disorder
ZHANG Yingqian, ZHAO Guangyi, HAN Yuwei, ZHANG Jingyi, CAO Chengqi, WANG Li, ZHANG KunlinCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
Received:2020-11-17Online:2022-01-15Published:2021-11-25摘要/Abstract
摘要： 创伤后应激障碍是一种具有复杂病因学的精神疾病, 多发生于个体受到重大创伤事件后。创伤后应激障碍的发生发展过程受到环境和遗传易感性的共同作用, 存在着较大的个体差异; 而表观遗传学作为一门研究多变环境因素调控基因表达的可遗传变化的学科, 近年来在创伤后应激障碍的研究中受到越来越多的重视。表观遗传机制之一——组蛋白修饰机制在创伤后应激障碍的发生中起着重要作用, 并且由于组蛋白修饰可以受到多种酶的调控, 其灵活的可逆化和精细调控为相应的药物研发提供了可能性和便利。因此, 深入探讨创伤后应激障碍的组蛋白修饰机制, 对于相关疾病的临床治疗及药物研发具有十分重要的意义。当前创伤后应激障碍的组蛋白修饰研究主要使用动物模型, 临床研究较少; 组蛋白的类型则主要关注组蛋白H3和H4乙酰化; 此外, 同以往的研究结果一致, 组蛋白修饰水平的变化主要发生在前额叶、海马体和杏仁核区域, 参与免疫系统、血清素系统和神经肽Y能系统等相关通路的调节。当前PTSD组蛋白修饰的研究结果间还存在较大的异质性, 未来的研究应采用更加一致和实用的分析和报道方法, 以最大限度地发挥研究的影响。
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